Publications - Seidel Carole - Page 1

4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90a chaperone ac...

Seidel Carole Michael Schnekenburger Aloran Mazunder Marie-Hélène Teiten Gilbert Kirsch Mario Dicato Marc Diederich

Published in Biochemical Pharmacology in Jan 02, 2016

Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including a-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...

Chromatin-modifying agents in anti-cancer therapy

Michael Schnekenburger Mario Dicato Seidel Carole Marc Diederich

Published in Biochimie

Epigenetic alterations are involved in every step of carcinogenesis. The development of chromatin- modifying agents (CMAs) has provided the ability to fight cancer by reversing these alterations. Currently, four CMAs have been approved for cancer treatment; two DNA demethylating agents and two deacetylase inhibitors. A number of promising CMAs are ...

Histone deacetylase modulators provided by Mother Nature

Seidel Carole Michael Schnekenburger Mario Dicato Marc Diederich

Published in Genes & Nutrition

Protein acetylation status results from a balance between histone acetyltransferase and histone deacetylase (HDAC) activities. Alteration of this balance leads to a disruption of cellular integrity and participates in the development of numerous diseases, including cancer. Therefore, modulation of these activities appears to be a promising approach...