Publications - Rolando Yanes - Page 1

Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug deli...

Rolando Yanes Derrick Tarn Angela A Hwang Daniel P Ferris Sean P Sherman Courtney R Thomas Jie Lu April D Pyle Jeffrey I Zink Fuyuhiko Tamanoi ...

Published in Small Group Research

The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-...

Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery.

Rolando Yanes Fuyuhiko Tamanoi

Published in Therapeutic Delivery

The development of delivery vehicles that would carry therapeutic agents selectively to cancer cells has become an important focus in biomedical research. Nanoparticles have received much attention because the advances made in this field have resulted in multiple biocompatible materials. In particular, mesoporous silica nanoparticles (MSNs) offer a...

Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells...

Daniel P Ferris Jie Lu Chris Gothard Rolando Yanes Courtney R Thomas John-Carl Olsen J Fraser Stoddart Fuyuhiko Tamanoi Jeffrey I Zink

Published in Small

Synthetic methodologies integrating hydrophobic drug delivery and biomolecular targeting with mesoporous silica nanoparticles are described. Transferrin and cyclic-RGD peptides are covalently attached to the nanoparticles utilizing different techniques and provide selectivity between primary and metastatic cancer cells. The increase in cellular upt...

OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids.

Rongsong Li Wendy Chen Rolando Yanes Sangderk Lee Judith A Berliner

Published in The Journal of Lipid Research

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is present in oxidative modified LDL and accumulates in lesions of many chronic inflammatory diseases, such as atherosclerosis. In a microarray study, OxPAPC has been demonstrated to modulate the expression of >700 genes in human aortic endothelial cells. We found that the ...