Publications - Ri-Yao Yang - Page 1

Galectins are a family of animal lectins with conserved carbohydrate-recognition domains for beta-galactoside. Galectin-3 is the only family member that is composed of a glycine/prolinerich N-terminal repeated sequence and a C-terminal carbohydrate-binding domain.Multiple functions of galectin-3 have been reported, depending on its location. Extrac...

Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance.

Ri-Yao Yang Pj, Havel Fu-Tong Liu

Published in Adipocyte

Galectin-12, a member of the galectin family of animal lectins, is preferentially expressed in adipocytes. We recently reported that this galectin is localized on lipid droplets, specialized organelles for fat storage. Galectin-12 regulates lipid degradation (lipolysis) by modulating lipolytic protein kinase A (PKA) signaling. Mice deficient in gal...

Frontline Science: Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while pro...

H, Xue Ri-Yao Yang G, Tai Fu-Tong Liu

Published in Journal of Leukocyte Biology

Analysis of the intracellular role of galectins in cell growth and apoptosis.

Daniel Hsu Ri-Yao Yang J, Saegusa Fu-Tong Liu

Published in Methods in Molecular Biology

Galectins are a family of animal lectins with conserved carbohydrate-recognition domains that recognize β-galactosides. Despite structural similarities, these proteins have diverse functions in a variety of cellular processes. While a large number of extracellular functions have been demonstrated for galectins, the existence of intracellular functi...

Galectins in acute and chronic inflammation.

Fu-Tong Liu Ri-Yao Yang Daniel Hsu

Published in Annals of the New York Academy of Sciences

Galectins are animal lectins that bind to β-galactosides, such as lactose and N-acetyllactosamine, in free form or contained in glycoproteins or glycolipids. They are located intracellularly or extracellularly. In the latter they exhibit bivalent or multivalent interactions with glycans on cell surfaces and induce various cellular responses, includ...

Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration.

W, Liu Daniel Hsu Huan-Yuan Chen Ri-Yao Yang 3rd, Carraway Kl Rr, Isseroff Fu-Tong Liu

Published in Journal of Investigative Dermatology

The EGFR-mediated signaling pathways are important in a variety of cellular processes, including cell migration and wound re-epithelialization. Intracellular trafficking of EGFR is critical for maintaining EGFR surface expression. Galectin-3, a member of an animal lectin family, has been implicated in a number of physiological and pathological proc...

Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insul...

Ri-Yao Yang Lan Yu Jl, Graham Daniel Hsu Kc, Lloyd Pj, Havel Fu-Tong Liu

Published in Proceedings of the National Academy of Sciences

The breakdown of triglycerides, or lipolysis, is a tightly controlled process that regulates fat mobilization in accord with an animal s energy needs. It is well established that lipolysis is stimulated by hormones that signal energy demand and is suppressed by the antilipolytic hormone insulin. However, much still remains to be learned about regul...

Galectins: structure, function and therapeutic potential.

Ri-Yao Yang Ga, Rabinovich Fu-Tong Liu

Published in Expert Reviews in Molecular Medicine

Galectins are a family of animal lectins that bind beta-galactosides. Outside the cell, galectins bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular processes. However, galectins are also detectable in the cytosol and nucleus, and may influence cellular functions such as intracellular signalling pathways ...

Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis....

Ri-Yao Yang H, Xue Lan Yu A, Velayos-Baeza Ap, Monaco Fu-Tong Liu

Galectin-12, a member of the galectin family of β-galactoside-binding animal lectins, is preferentially expressed in adipocytes and required for adipocyte differentiation in vitro. This protein was recently found to regulate lipolysis, whole body adiposity, and glucose homeostasis in vivo. Here we identify VPS13C, a member of the VPS13 family of va...

Galectins in apoptosis.

Fu-Tong Liu Daniel Hsu Ri-Yao Yang

Published in G Protein Coupled Receptors - Structure

Galectins are a family of animal lectins with affinity for beta-galactosides. By using recombinant proteins, a number of galectins have been shown to interact with cell-surface and extracellular matrix glycoconjugates through lectin-carbohydrate interactions. Through this action, they can affect a variety of cellular processes, and the most extensi...