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S, Sen B, Kawahara Nl, Fry R, Farias-Eisner D, Zhang Pradip Mascharak G, Chaudhuri
Published in
Archives of Biochemistry and Biophysics
It is established that high concentrations of nitric oxide(1) (NO), as released from activated macrophages, induce apoptosis in breast cancer cells. In this study, we assessed the potential of a light-activated NO donor [(Me2bpb)Ru(NO)(Resf)], a recently reported apoptototic agent, in suppressing the anchorage independent growth potentials of an ag...
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I, Szundi Mj, Rose I, Sen Aa, Eroy-Reveles Pradip Mascharak O, Einarsdóttir
Published in
Photochemistry and Photobiology
Nitric oxide (NO) is recognized as one of the major players in various biochemical processes, including blood pressure, neurotransmission and immune responses. However, experimental studies involving NO are often limited by difficulties associated with the use of NO gas, including its toxicity and precise control over NO concentration. Moreover, th...
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La, Tyler Mm, Olmstead Pradip Mascharak
Published in
Inorganic Chemistry
The Co(III) complex of the Schiff base ligand N-2-mercaptophenyl-2 -pyridylmethyl-enimine (PyASH), namely, [Co(PyAS)(2)]Cl (1), has been synthesized via an improved method and its structure has been determined by X-ray crystallography. The two deprotonated ligands are arranged in mer configuration around the Co(III) center and the overall coordinat...
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Mj, Rose Mm, Olmstead Pradip Mascharak
Published in
Journal of the American Chemical Society
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Tr, Deboer I, Chakraborty Pradip Mascharak
Published in
Journal of Materials Science Materials in Medicine
Although application of silver nitrate and silver sulfadiazine have been shown to be effective in thwarting infections at burn sites, optimization of the delivery of bioactive silver (Ag(+)) remains as an obstacle due to rapid precipitation and/or insolubility of the silver sources. To circumvent these shortcomings, we have designed a silver(I) com...
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Ma, Gonzalez Nl, Fry R, Burt R, Davda A, Hobbs Pradip Mascharak
Published in
Inorganic Chemistry
The physiological roles of CO in neurotransmission, vasorelaxation, and cytoprotective activities have raised interest in the design and syntheses of CO-releasing materials (CORMs) that could be employed to modulate such biological pathways. Three iron-based CORMs, namely, [(PaPy(3))Fe(CO)](ClO(4)) (1), [(SBPy(3))Fe(CO)](BF(4))(2) (2), and [(Tpmen)...
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Mj, Rose Nl, Fry R, Marlow Lindsay Hinck Pradip Mascharak
Published in
Journal of the American Chemical Society
Three nitrosyl-dye conjugates, namely, [(Me 2bpb)Ru(NO)(Resf)] (1-Resf), [(Me 2bQb)Ru(NO)(Resf)] (2-Resf), and [((OMe) 2bQb)Ru(NO)(Resf)] (3-Resf) have been synthesized via direct replacement of the chloride ligand of the parent Ru-NO (6) nitrosyls of the type [(R 2byb)Ru(NO)(L)] with the anionic tricyclic dye resorufin (Resf). The structures of 1-...
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Bj, Heilman J, St John Sr, Oliver Pradip Mascharak
Published in
Journal of the American Chemical Society
A photoactive manganese nitrosyl, namely [Mn(PaPy(3))(NO)](ClO(4)) (Mn-NO), has been loaded into the columnar pores of an MCM-41 host. Strong interaction between the polar nitrosyl and the -OH groups on the host wall leads to excellent entrapment of the NO donor within the porous host. With the aluminosilicate-based host (Al-MCM-41), the loading is...
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Sj, Carrington I, Chakraborty Pradip Mascharak
Published in
Dalton Transactions
Two manganese(i) carbonyl complexes derived from α,α -diimine ligands with extended conjugated framework namely [MnBr(CO)3(BIAN)] () and [MnBr(CO)3(MIAN)] (), have been synthesized and structurally characterized. Unlike the previously reported photoactive CO-releasing molecules (photoCORMs), these two complexes exhibit unusually high sensitivity to...
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Nl, Fry J, Wei Pradip Mascharak
Published in
Inorganic Chemistry
Two new fluorescein-tethered nitrosyls derived from designed tetradentate ligands with carboxamido-N donors have been synthesized and characterized by spectroscopic techniques. These two diamagnetic Ru-NO(6) nitrosyls, namely, [(Me(2)bpb)Ru(NO)(FlEt)] (1-FlEt, Me(2)bpb = 1,2-bis(pyridine-2-carboxamido)5-dimethylbenzene, FlEt = fluorescein ethyl est...
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Sj, Carrington I, Chakraborty Pradip Mascharak
Published in
Chemical Communications
Two Mn(I) carbonyl complexes namely [MnBr(azpy)(CO)3] and [Mn(azpy)(CO)3(PPh3)](ClO4) (azpy = 2-phenylazopyridine) have been synthesized and characterized. Both complexes exhibit rapid CO release upon exposure to low power visible light. [MnBr(azpy)(CO)3] shows significant phototoxicity toward two malignant cell lines HeLa and MDA-MB-231.
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Cg, Hoffman-Luca Aa, Eroy-Reveles J, Alvarenga Pradip Mascharak
Published in
Inorganic Chemistry
Two manganese nitrosyls, namely, [Mn(SBPy(3))(NO)](ClO(4))(2) (1) and [Mn(SBPy(2)Q)(NO)](ClO(4))(2) (2), have been synthesized by using designed pentadentate Schiff base ligands N,N-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-aldimine (SBPy(3)) and N,N-bis(2-pyridyl methyl)amine-N-ethyl-2-quinoline-2-aldimine (SBPy(2)Q). Reaction of NO(g) with [...
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Tc, Harrop Mm, Olmstead Pradip Mascharak
Published in
Chemical Communications
A (mu-SR)2-nickel(II) dimer derived from a ligand with carboxamido nitrogen and thiolato sulfur donors reacts with O2 to afford an oxidized product in which phenyl groups of the ligand frames are oxidized to nickel-bound phenolates.
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Pradip Mascharak Y, Sugiura J, Kuwahara T, Suzuki Sj, Lippard
Published in
Proceedings of the National Academy of Sciences
The antitumor drug cis-diamminedichloroplatinum(II) dramatically alters the sequence-specific cleavage of the bleomycin A2-iron(II)-O2 system. Preferred bleomycin cleavage sites adjacent to oligo(dG) regions on two restriction fragments of plasmid pBR322 DNA were masked by pretreatment with cis-diamminedichloroplatinum(II). trans-Diamminedichloropl...
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Sj, Carrington I, Chakraborty Jm, Bernard Pradip Mascharak
Published in
ACS Medicinal Chemistry Letters
A designed photoactive CO releasing molecule (photoCORM), namely, fac-[MnBr(CO)3(pbt)] (1, pbt = 2-(2-pyridyl)benzothiazole), promotes CO-induced death of MDA-MB-231 human breast cancer cells upon illumination with broadband visible light. The CO release from this photoCORM can be tracked by rise in fluorescence within the cellular matrix due to de...
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Et, Farinas Jd, Tan Pradip Mascharak
Published in
Inorganic Chemistry
A 2,4 -bithiazole group has been covalently attached to the Co(III) complex of a designed ligand PMAH that mimics the metal-binding locus of the antitumor drug bleomycin (BLM). The deprotonated PMA(-) ligand binds Co(III) via five nitrogens located in primary and secondary amines, a pyrimidine and an imidazole ring, and a peptide moiety. The 2,4 -b...
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Se, Hudson Pradip Mascharak
Published in
Chemical Research in Toxicology
The capacity of free-radical formation and concomitant radical-induced DNA damage by [Cu(PMA)]X (X = ClO4-, BF4-), the first crystalline synthetic analogue of Cu(II)-BLM, have been studied. In phosphate buffer, [Cu(PMA)]+ can be reduced by thiols like DTT to a Cu(I) species that can be reoxidized with dioxygen. During oxygenation of the Cu(I) analo...
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Ak, Patra Mm, Olmstead Pradip Mascharak
Published in
Inorganic Chemistry
The iron complexes of a designed pentadentate Schiff base ligand N,N-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-aldimine (SBPy(3)) have been synthesized. The low-spin mononuclear Fe(III) complex [(SBPy(3))Fe(DMF)](ClO(4))(3) (2), though stable in the solid state, is spontaneously reduced to the corresponding Fe(II) species [(SBPy(3))Fe(MeCN)](2...
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Jm, Rowland Mm, Olmstead Pradip Mascharak
Published in
Inorganic Chemistry
Reaction of Cu(ClO(4))(2) x 6H(2)O with a racemic mixture of the novel chiral ligand N-(1,2-bis(2-pyridyl)ethyl)pyridine-2-carboxamide (PEAH) affords only the homochiral dimeric copper(II) complexes [Cu(2)((R)()PEA)(2)](ClO(4))(2) and [Cu(2)((S)()PEA)(2)](ClO(4))(2) in a 1:1 ratio. The phenomenon of molecular self-recognition is also observed when ...
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Ma, Gonzalez Sj, Carrington I, Chakraborty Mm, Olmstead Pradip Mascharak
Published in
Inorganic Chemistry
One monocarbonyl and one dicarbonyl complex of ruthenium(II), namely, [Ru(Cl)(CO)(qmtpm)(PPh3)]BF4 (2) and [Ru(Cl)(CO)2(qmtpm)]ClO4 (3), derived from the tridentate ligand 2-quinoline-N-(2 -methylthiophenyl)methyleneimine (qmtpm) have been synthesized and structurally characterized. The qmtpm ligand binds in a meridional fashion in these carbonyl c...
