Publications - Poornima Kolhar - Page 1

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium.

Poornima Kolhar Ac, Anselmo V, Gupta K, Pant B, Prabhakarpandian Erkki Ruoslahti S, Mitragotri

Published in Proceedings of the National Academy of Sciences

Vascular endothelium offers a variety of therapeutic targets for the treatment of cancer, cardiovascular diseases, inflammation, and oxidative stress. Significant research has been focused on developing agents to target the endothelium in diseased tissues. This includes identification of antibodies against adhesion molecules and neovascular express...

Synthetic surfaces for human embryonic stem cell culture.

Poornima Kolhar V. Ramana Kotamraju St, Hikita Do, Clegg Erkki Ruoslahti

Published in Journal of Biotechnology

Human embryonic stem cells (hESCs) have numerous potential biomedical applications owing to their unique abilities for self-renewal and pluripotency. Successful clinical application of hESCs and derivatives necessitates the culture of these cells in a fully defined environment. We have developed a novel peptide-based surface that uses a high-affini...