Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium.
Published in Proceedings of the National Academy of Sciences
Vascular endothelium offers a variety of therapeutic targets for the treatment of cancer, cardiovascular diseases, inflammation, and oxidative stress. Significant research has been focused on developing agents to target the endothelium in diseased tissues. This includes identification of antibodies against adhesion molecules and neovascular express...