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Phil Berman Sf, Heinemann
Published in
The Journal of Immunology
Myasthenia gravis (MG) is a disease thought to result from an autoimmune response against the nicotinic acetylcholine receptor of the neuromuscular junction. Although there is little doubt that the muscular weakness characteristic of MG can be attributed to an antibody-mediated reduction in the density of AChR, the mechanism responsible for this re...
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M, Pérez-Losada D, Posada M, Arenas Dv, Jobes F, Sinangil Phil Berman Ka, Crandall
Published in
Retrovirology
Differences in HIV-1 gp120 sequence variation were examined in North American volunteers who became infected during a phase III vaccine trial using the rgp120 vaccine. Molecular adaptation of the virus in vaccine and placebo recipients from different ethnic subgroups was compared by estimating the dN/dS ratios in viruses sampled from each individua...
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Phil Berman Kk, Murthy T, Wrin Jc, Vennari Ek, Cobb Dj, Eastman M, Champe Gr, Nakamura D, Davison Mf, Powell
...
Published in
The Journal of Infectious Diseases
Three chimpanzees immunized with recombinant gp120 from human immunodeficiency virus type 1 (HIV-1) strain MN and 1 control animal were challenged intravenously with a primary isolate of HIV-1SF2. Viral infection was detected in the control animal by viral culture, polymerase chain reaction, and multiple serologic assays beginning 2 weeks after inf...
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Cm, Gomez Dp, Richman Sa, Burres Bg, Arnason Phil Berman Fw, Fitch
Published in
Annals of the New York Academy of Sciences
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Sm, O Rourke B, Schweighardt P, Phung Ka, Mesa Al, Vollrath Gp, Tatsuno B, To F, Sinangil K, Limoli T, Wrin
...
Published in
Journal of Virology
The swarm of quasispecies that evolves in each HIV-1-infected individual represents a source of closely related Env protein variants that can be used to explore various aspects of HIV-1 biology. In this study, we made use of these variants to identify mutations that confer sensitivity and resistance to the broadly neutralizing antibodies found in t...
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Pb, Gilbert Ml, Ackers Phil Berman Dp, Francis V, Popovic Dj, Hu Wl, Heyward F, Sinangil Be, Shepherd M, Gurwith
...
Published in
The Journal of Infectious Diseases
The first trial of the efficacy of a human immunodeficiency virus (HIV)-1 vaccine was conducted in North America and The Netherlands between 1998 and 2003. This multicenter, randomized, placebo-controlled trial of a recombinant glycoprotein 120 vaccine included 5403 initially HIV-negative volunteers who were monitored for 3 years. The 368 subjects ...
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Jm, Zarling Pa, Moran Rl, Burke C, Pachl Phil Berman La, Lasky
Published in
The Journal of Immunology
Results of studies in mice and clinical observations in man indicate that T cell-mediated immunity is important in resistance to herpes simplex virus (HSV) infections. This study was undertaken to elucidate the viral antigen specificity of human HSV-immune T cells. Purified HSV-1 glycoproteins gB-1 and gD-1, cloned and expressed in mammalian cells,...
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Gr, Nakamura Dp, Fonseca Sm, O Rourke Al, Vollrath Phil Berman
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Phil Berman J, Patrick S, Heinemann Fg, Klier Jh, Steinbach
Published in
Annals of the New York Academy of Sciences
Mice immunized with purified AChR (T. californica) invariably form anti-AChR antibodies and often develop a condition of extreme muscular weakness and flaccid paralysis. Pharmacological, physiological, and ultrastructural studies indicate that the pathophysiology of EMG in the mouse closely resembles that of human MG. The single episode of muscular...
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B, Yu Jf, Morales Sm, O Rourke Gp, Tatsuno Phil Berman
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Fk, Graham Cb, Ernhart M, Craft Phil Berman
Published in
The Psychological Monographs
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M, Pérez-Losada Dv, Jobes F, Sinangil Ka, Crandall M, Arenas D, Posada Phil Berman
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R, Gottardo Rt, Bailer Bt, Korber S, Gnanakaran J, Phillips X, Shen Gd, Tomaras E, Turk G, Imholte L, Eckler
...
Neutralizing and non-neutralizing antibodies to linear epitopes on HIV-1 envelope glycoproteins have potential to mediate antiviral effector functions that could be beneficial to vaccine-induced protection. Here, plasma IgG responses were assessed in three HIV-1 gp120 vaccine efficacy trials (RV144, Vax003, Vax004) and in HIV-1-infected individuals...
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Fk, Graham Phil Berman
Published in
American Journal of Orthopsychiatry
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Sa, Lee R, Orque Pa, Escarpe Ml, Peterson Jw, Good Em, Zaharias Phil Berman Hw, Sheppard R, Shibata
Published in
Vaccine
A simple and sensitive method for measuring antibodies to primary human immunodeficiency virus type 1 (HIV-1) isolates has been developed. The flow cytometric immuno-fluorescence assay detects antibodies that bind to the native, oligomeric form of the envelope glycoprotein (gp120) expressed on the surface of PM-1 cells infected with primary isolate...
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Phil Berman
Published in
Journal of the American Academy of Dermatology
A subunit vaccine consisting of glycoprotein D from the surface of herpes simplex virus was prepared using recombinant deoxyribonucleic acid techniques to transfer the viral gene for glycoprotein D into Chinese hamster ovary cells. The glycoprotein D produced by these Chinese hamster cells combined with appropriate adjuvants effectively immunized m...
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Me, Binnerts Y, Van Kooyk Cp, Edwards M, Champe L, Presta Sc, Bodary Cg, Figdor Phil Berman
Published in
Journal of Biological Chemistry
Several studies indicate that the I domain located in the alpha chain (CD11a) of leukocyte function-associated antigen-1 (LFA-1; CD11a/CD18) plays an essential role in ligand recognition. We recently identified three distinct epitopes (IdeA, IdeB, and IdeC) within the CD11a I domain, recognized by antibodies that block binding of LFA-1 to intercell...
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Ra, Weiss Pr, Clapham Jn, Weber Ag, Dalgleish La, Lasky Phil Berman
Published in
Nature
Human immunodeficiency virus type 1 (HIV-1, HTLV-III/LAV), the retrovirus responsible for acquired immune deficiency syndrome (AIDS), shows a high degree of genetic polymorphism, particularly in the env gene. We have examined sera from rabbits and guinea pigs immunized with gp130, a recombinant env glycoprotein, and sera from HIV-1-infected subject...
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Phil Berman Gr, Nakamura L, Riddle H, Chiu K, Fisher M, Champe Am, Gray P, Ward S, Fong
Published in
Journal of Cellular Biochemistry
Full-length (membrane bound) and truncated (secreted) forms of the beta 2 integrin heterodimer, CD11b/CD18 (Mac-1), were expressed in a human kidney cell line (293) that normally does not express leukocyte adhesion molecules (Leu-CAMs). The biosynthesis of recombinant Mac-1 in 293 cells differed from that reported for leukocytes in that heterodimer...
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Jw, Torseth Phil Berman Tc, Merigan
Published in
AIDS Research and Human Retroviruses
Peripheral blood mononuclear cell (PBMC) cultures were established from patients with antibody to human immunodeficiency virus (HIV). Asymptomatically infected patients [5 of 19] had significant lymphocyte transformation responses induced in culture by a purified, recombinant envelope glycoprotein (rgp120) from the virus. A few (4 of 55) subjects w...
