Pamela Yao

Interferon-gamma inhibits healing post scald burn injury.

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H, Shen Pamela Yao E, Lee D, Greenhalgh Athena Soulika

Published in Wound Repair and Regeneration

Impaired healing after severe burns remains a reason for prolonged hospitalization, opportunistic infections, and debilitating scarring. Interferon-gamma (IFN-γ) is an important immune regulator that has been shown to inhibit collagen synthesis by fibroblasts, resulting in delayed healing in incision wounds. To determine whether IFN-γ plays similar...

Therapeutic depletion of monocyte-derived cells protects from long-term axonal loss in experimental autoimmune encephalo...

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Ma, Moreno T, Burns Pamela Yao L, Miers D, Pleasure Athena Soulika

Published in Journal of Neuroimmunology

Studies in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) suggest that peripheral monocyte-derived cells (MDCs) are instrumental for disease initiation. MDCs, however, are plastic, and may exert various functions once in the central nervous system (CNS) for prolonged periods. Furthermore, the long-term effec...