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Araujo, Luiza M Fert, Ingrid Jouhault, Quentin Labroquère, Karine Muriel Andrieu Chiocchia, Gilles Breban, Maxime
Published in
Biochemical Society Symposium
We observed dysregulated production of IL-10 and IL-17 by Treg cells from B27-transgenic rats, which may contribute to disease development. Moreover, our data highlight a key role for ICOS signaling in the generation of imbalanced production of IL-10 and IL-17 by Treg cells in this experimental model of spondyloarthritis.
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Diouf, Ibrahima Fievet, Nadine Doucouré, Souleymane Ngom, Mamadou Muriel Andrieu Mathieu, Jean-François Gaye, Alioune Thiaw, Omar Thiom Philippe Deloron
Published in
Cancer causes & control : CCC
Placental Plasmodium falciparum sequestration is associated with dysregulated immune function. Placental inflammatory responses via IFN-gamma and TNF-alpha are implicated in functional damage. However, they are needed during placental infection to control asexual stage parasites. To test the hypothesis that placental immunomodulation associated wit...
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Castelli, Florence A Leleu, Mélanie Pouvelle-Moratille, Sandra Farci, Sandrine Zarour, Hassane M Muriel Andrieu Auriault, Claude Ménez, André Georges, Bertrand Maillere, Bernard
...
Published in
The Journal of Physical Chemistry B
To understand the inter-individual and virus-independent variability of CD4+ T cell responses to HCV components, we evaluated the effect on these responses of HLA II molecules in uninfected healthy donors. Using HLA II-specific binding assays, we identified, in the Core and NS3 proteins, 21 long fragments and 24 15-mer peptides that bound to four t...
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Carrière, Matthieu Pène, Véronique Breiman, Adrien Conti, Filoména Chouzenoux, Sandrine Meurs, Eliane Muriel Andrieu Jaffray, Patrick Grira, Lilia Soubrane, Olivier
...
Published in
Harm Reduction Journal
The detection of negative-strand hepatitis C virus (HCV) RNA is a hallmark of replication. A highly sensitive and specific method is required to quantify the very low level of replication inherent to in vitro infection systems. Based on reverse transcription with a tagged primer in the 5' non-coding region of the HCV genome, followed by a nested PC...
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Gahery, Hanne Daniel, Nathalie Charmeteau, Bénédicte Ourth, Lucie Jackson, Angéla Muriel Andrieu Choppin, Jeannine Salmon, Dominique Pialoux, Gilles Guillet, Jean-Gerard
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Published in
Journal of Microbiology Immunology and Infection
We showed that an anti-HIV lipopeptide vaccine injected to HIV-uninfected volunteers was well tolerated and able to induce a specific CD4(+) and CD8(+) T cell responses. The same vaccine was injected in HIV-1 chronically infected patients controlled by HAART to evaluate its immunogenicity. In this trial, 24 patients were immunized three times with ...
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Guille, Marina Muriel Andrieu Braudeau, Cécile Ruiz, Catherine Daniel, Nathalie Pallier, Annaïck Charmeteau, Bénédicte Veziers, Joelle Oden, Neal Bonilla, Nelly
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Published in
Journal of Microbiology Immunology and Infection
In this article, we studied the T cell receptor (TCR)beta chain transcript mobilization in peripheral blood lymphocytes harvested from HIV-1-infected patients before and after vaccination with a mixture of six lipopeptides and at the moment and serially after highly active antiretroviral therapy (HAART) interruption. This study was performed by usi...
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Inwoley, André Recordon-Pinson, Patricia Dupuis, Marion Gaston, Jessintha Genête, Mathieu Minga, Albert Letourneur, Franck Rouet, François Choppin, Jeannine Fleury, Hervé
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Published in
Journal of Microbiology Immunology and Infection
Most HIV vaccine trials in the world are conducted with clade B while most circulating viral strains in Africa are non-B subtypes. We determined whether CD8+ T cells from HIV-1 intersubtype CRF02_AG-infected Ivorian individuals were able to recognize clade B epitopes. CD8+ T cell responses of nine HIV-1 intersubtype CRF02_AG-infected Ivorian patien...
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Daniel, Nathalie Charmeteau, Bénédicte Grabar, Sophie Pialoux, Gilles Salmon, Dominique Bonilla, Nelly Dupuis, Marion Troadec, Christelle Rozenbaum, Willy Gahéry-Ségard, Hanne
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Published in
Journal of Microbiology Immunology and Infection
Highly active antiretroviral therapy (HAART) is associated with a dramatic clinical benefit to HIV-infected patients through significant plasma viremia reduction and CD4(+) T cells increase. In previous reports, HIV-specific CD4(+) and/or CD8(+) T cell responses have been studied separately during HAART; therefore the relationship between these two...
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Rouard, Helene Klonjkowski, Bernard Marquet, Jeanine Lahet, Chantal Mercier, Stephanie Muriel Andrieu Maison, Patrick Molinier-Frenkel, Valerie Eloit, Marc Farcet, Jean-Pierre
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Published in
AIDS (London, England)
Therapeutic vaccination aims at a strong stimulation of antigen-specific CD8(+) T-cells, so that they differentiate into effectors active in vivo against antigenic targets. Two adenovirus vectors (Ad) encoding two HLA-A*0201-restricted HIV epitope sequences (pol 476 and pol 589) were constructed. The Ad differ by the presence or absence of a ubiqui...
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Seifert, Ulrike Maranon, Concepcion Shmueli, Ayelet Desoutter, Jean-Francois Wesoloski, Lisa Janek, Katharina Henklein, Peter Diescher, Susanne Muriel Andrieu de la Salle, Henri
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Seifert, Ulrike Marañón, Concepción Shmueli, Ayelet Desoutter, Jean-François Wesoloski, Lisa Janek, Katharina Henklein, Peter Diescher, Susanne Muriel Andrieu de la Salle, Henri
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Published in
Human Immunology
Most of the peptides presented by major histocompatibility complex (MHC) class I molecules require processing by proteasomes. Tripeptidyl peptidase II (TPPII), an aminopeptidase with endoproteolytic activity, may also have a role in antigen processing. Here, we analyzed the processing and presentation of the immunodominant human immunodeficiency vi...
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Muriel Andrieu Desoutter, Jean-François Loing, Estelle Gaston, Jésintha Hanau, Daniel Guillet, Jean-Gérard Anne Hosmalin
Published in
Molecular and Biochemical Parasitology
An efficient vaccine against human immunodeficiency virus (HIV) must induce good cellular immune responses. To do this, it must be processed and presented by dendritic cells, which are required for primary T-lymphocyte stimulation. We have previously shown that a model lipopeptide containing a short epitopic peptide from HIV-1 was endocytosed and p...
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Van Overtvelt, Laurence Muriel Andrieu Verhasselt, Valérie Connan, Francine Choppin, Jeannine Vercruysse, Vincent Goldman, Michel Anne Hosmalin Vray, Bernard
Published in
Rheumatology (Oxford, England)
Trypanosoma cruzi, the etiological agent of Chagas' disease, may persist for many years in its mammalian host. This suggests escape from the immune response and particularly a suboptimal CD8(+) T cell response, since these cells are involved in infection control. In this report, we show that T. cruzi inhibits the lipopolysaccharide (LPS)-induced up...
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Muriel Andrieu GUILLET, JEAN-GERARD
FR