Milan Makale

Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs.

Published in Journal of Translational Medicine

Assembly and targeting of liposomal nanoparticles encapsulating quantum dots.

Published in Bioconjugate Chemistry

Quantum dots (QDs) are attracting intense interest as fluorescence labeling agents for biomedical imaging because biocompatible coatings and relatively nontoxic rare earth metal QDs have emerged as possible options. QD photoemissions are bright, of narrow wavelength range, and very stable. We sought to encapsulate QDs within targeted PEGylated lipo...

In silico modeling predicts drug sensitivity of patient-derived cancer cells.

Published in Journal of Translational Medicine

High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor resp...

Published in International Journal of Nanomedicine

Staurosporine (STS) is a potent pan-kinase inhibitor with marked activity against several chemotherapy-resistant tumor types in vitro. The translational progress of this compound has been hindered by poor pharmacokinetics and toxicity. We sought to determine whether liposomal encapsulation of STS would enhance antitumor efficacy and reduce toxicity...

Characterization of a human tumorsphere glioma orthotopic model using magnetic resonance imaging.

Published in Journal of Neuro-Oncology

Magnetic resonance imaging (MRI) is the imaging modality of choice by which to monitor patient gliomas and treatment effects, and has been applied to murine models of glioma. However, a major obstacle to the development of effective glioma therapeutics has been that widely used animal models of glioma have not accurately recapitulated the morpholog...

Cell phones and glioma risk: a review of the evidence.

Published in Journal of Neuro-Oncology

Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres.

Published in Journal of Translational Medicine

Hyaluronan expression in primary and secondary brain tumors.

Published in Annals of Translational Medicine

Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases.

Published in Cancer Cell International

Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma.

Published in Oncotarget

The extrinsic coagulation cascade and tissue factor pathway inhibitor in macrophages: a potential therapeutic opportunit...

Published in Thrombosis Research

Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor ...

Published in Bioconjugate Chemistry

Dextran-coated superparamagnetic iron oxide nanoparticles (dextran-SPIO conjugates) offer the attractive possibility of enhancing MRI imaging sensitivity so that small or diffuse lesions can be detected. However, systemically injected SPIOs are rapidly removed by macrophages. We engineered embryonic cells (HEK293T) to express major macrophage scave...

PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.

Published in Journal of Neuro-Oncology

Glioblastoma (GBM) is the most common brain cancer and is highly lethal in both adults and children. 2-methoxyestradiol (2ME2) is a microtubule inhibitor that potently inhibits HIF1α, GBM angiogenesis and tumor growth in preclinical models. In patients, 2ME2 exhibits low toxicity and promising but inconsistent efficacy. Given its preclinical potenc...

Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging.

Published in Journal of Biomedical Optics

Early detection is important for many solid cancers but the images provided by ultrasound, magnetic resonance imaging (MRI), and computed tomography applied alone or together, are often not sufficient for decisive early screening ∕ diagnosis. We demonstrate that MRI augmented with fluorescence intensity (FI) substantially improves detection. Early ...