Michael Kramer

Inferring gene ontologies from pairwise similarity data.

Published in Bioinformatics

NeXO Web: the NeXO ontology database and visualization platform.

Published in Nucleic Acids Research

The Network-extracted Ontology (NeXO) is a gene ontology inferred directly from large-scale molecular networks. While most ontologies are constructed through manual expert curation, NeXO uses a principled computational approach which integrates evidence from hundreds of thousands of individual gene and protein interactions to construct a global hie...

A gene ontology inferred from molecular networks.

Published in Nature Biotechnology

Ontologies have proven very useful for capturing knowledge as a hierarchy of terms and their interrelationships. In biology a major challenge has been to construct ontologies of gene function given incomplete biological knowledge and inconsistencies in how this knowledge is manually curated. Here we show that large networks of gene and protein inte...