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Fumery, Mathurin Seksik, Philippe Auzolle, Claire Munoz-Bongrand, Nicolas Gornet, Jean-Marc Boschetti, Gilles Cotte, Eddy Buisson, Anthony Dubois, Anne Pariente, Benjamin
...
Published in
The American Journal of Gastroenterology
Objectives: We sought to determine the frequency of and risk factors for early (30-day) postoperative complications after ileocecal resection in a well-characterized, prospective cohort of Crohn's disease patients.
Methods: The REMIND group performed a nationwide study in 9 French university medical centers. Clinical-, biological-, surgical-, an...
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Simon, Marion Pariente, Benjamin Lambert, Jérôme Cosnes, Jacques Bouhnik, Yoram Marteau, Philippe Matthieu Allez Colombel, Jean-Frédéric Gornet, Jean-Marc
Published in
Clinical Gastroenterology and Hepatology
Background & aims: Little is known about the efficacy and safety of thalidomide therapy for patients with refractory Crohn's disease (CD), particularly in respect to long-term outcomes of patients.
Methods: We conducted a retrospective multicenter observational study to evaluate thalidomide efficacy and the probability of its withdrawal because ...
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Dohan, Anthony Taylor, Stuart Hoeffel, Christine Barret, Maximilien Matthieu Allez Dautry, Raphael Zappa, Magaly Savoye-Collet, Céline Dray, Xavier Boudiaf, Mourad
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Published in
Journal of Magnetic Resonance Imaging
Over the past years, technological improvements and refinements in magnetic resonance imaging (MRI) hardware have made high-quality diffusion-weighted imaging (DWI) routinely possible for the bowel. DWI is promising for the detection and characterization of lesions in Crohn's disease (CD) and has been advocated as an alternative to intravenous gado...
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Carbonnel, Franck Colombel, Jean Frédéric Filippi, Jérome Katsanos, Konstantinos H. Peyrin-Biroulet, Laurent Matthieu Allez Nachury, Maria Novacek, Gottfried Danese, Silvio Abitbol, Vered
...
Published in
Gastroenterology
Background & aims: Parenteral methotrexate is an effective treatment for patients with Crohn's disease, but has never been adequately evaluated in patients with ulcerative colitis (UC). We conducted a randomized controlled trial to determine its safety and efficacy in patients with steroid-dependent UC.
Methods: We performed a double-blind, plac...
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Abitbol, Yael Laharie, David Cosnes, Jacques Matthieu Allez Nancey, Stéphane Amiot, Aurélien Aubourg, Alexandre Fumery, Mathurin Altwegg, Romain Michetti, Pierre
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Published in
Journal of Crohn's and Colitis
Aim: to describe the characteristics of incident cases of tuberculosis [TB] despite negative TB screening tests, in patients with inflammatory bowel disease [IBD] undergoing anti-TNF treatment, and to identify the risk factors involved.
Methods: A retrospective descriptive study was conducted at GETAID centers on all IBD patients undergoing anti...
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Lim, Ai Ing Menegatti, Silvia Bustamante, Jacinta Le Bourhis, Lionel Matthieu Allez Rogge, Lars Jean-Laurent Casanova Yssel, Hans Di Santo, James P.
Published in
Journal of Experimental Medicine
Group 2 innate lymphoid cells (ILC2) include IL-5- and IL-13-producing CRTh2(+)CD127(+)cells that are implicated in early protective immunity at mucosal surfaces. Whereas functional plasticity has been demonstrated for both human and mouse ILC3 subsets that can reversibly give rise to IFN-γ-producing ILC1, plasticity of human or mouse ILC2 has not ...
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Amiot, Aurelien Grimaud, Jean-Charles Peyrin-Biroulet, Laurent Filippi, Jérome Pariente, Benjamin Roblin, Xavier Buisson, Anthony Stefanescu, Carmen Trang-Poisson, Caroline Altwegg, Romain
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Published in
Clinical Gastroenterology and Hepatology
Background & aims: Phase 3 trials have shown the efficacy of vedolizumab, which binds to integrin α4β7, in patients with Crohn's disease (CD) or ulcerative colitis (UC). We investigated the effectiveness and safety of vedolizumab in patients who failed anti-tumor necrosis factor therapy.
Methods: From June through December 2014, there were 173 p...
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Marteau, Philippe Laharie, David Colombel, Jean-Frédéric Martin, Laurence Coevoet, Hugues Matthieu Allez Cadiot, Guillaume Bourreille, Arnaud Carbonnel, Franck Bouhnik, Yoram
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Published in
Journal of Crohn's and Colitis
The reproducibility of the RS was moderate, especially when differentiating 10% of patients.
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Wils, Pauline Bouhnik, Yoram Michetti, Pierre Flourie, Bernard Brixi, Hedia Bourrier, Anne Matthieu Allez Duclos, Bernard Grimaud, Jean-Charles Buisson, Anthony
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Published in
Clinical Gastroenterology and Hepatology
Background & aims: Ustekinumab, a human monoclonal antibody against the p40 subunit of interleukins-12 and -23, is effective in inducing and maintaining remission in patients with luminal Crohn's disease (CD). We assessed the efficacy and safety of subcutaneous ustekinumab in patients with anti-tumor necrosis factor (anti-TNF) refractory CD.
Met...
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Hawkey, Christopher J Matthieu Allez Clark, Miranda M Labopin, Myriam Lindsay, James O Ricart, Elena Rogler, Gerhard Rovira, Montserrat Satsangi, Jack Danese, Silvio
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Published in
JAMA
IMPORTANCE: Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease. OBJECTIVE: To evaluate the effect of autologous HSCT on refractory Crohn disease. DESIGN, SETTING, AND PARTICIPANTS: Parallel-group randomized clinical trial conducted in 11 European transplant units from July 200...
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Harbord, Marcus Annese, Vito Vavricka, Stephan R Matthieu Allez Barreiro-de Acosta, Manuel Boberg, Kirsten Muri Burisch, Johan De Vos, Martine De Vries, Anne-Marie Dick, Andrew D
...
Published in
Journal of Crohn's and Colitis
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Netter, Jeanne Jacqueline Lehmann-Che Lambert, Jerome Tallet, Anne Lourenco, Nelson Soliman, Hany Bertheau, Philippe Pariente, Benjamin Chirica, Mircea Marc Pocard
...
Published in
Bulletin du Cancer
Background
Survival of metastatic colon cancer (mCC) patients has considerably improved with optimization of new drugs regimen. Inactivation of TP53 pathway by TP53 mutations is observed in nearly half of colorectal tumors. The impact of such mutations has been poorly studied in the metastatic setting.
Methods
The files of 254 mCC treated in a...
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Ternant, David Berkane, Zahir Picon, Laurence Gouilleux-Gruart, Valerie Colombel, Jean-Frederic Matthieu Allez Louis, Edouard Paintaud, Gilles
Published in
Clinical Pharmacokinetics
Background and objectives: Infliximab is a monoclonal anti-tumor necrosis factor-α (anti-TNFα) antibody that profoundly modified the treatment of Crohn's disease (CD). The polymorphism of Fc fragment of IgG, low affinity IIIa, receptor (CD16a) [FCGR3A] influences the biological response to infliximab in patients with CD. Our aim was to study its in...
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Gagniere, C. Beaugerie, L. Pariente, B. Seksik, P. Amiot, A. Abitbol, V. Matthieu Allez Cosnes, J. Sokol, H.
Published in
Journal of Crohn's and Colitis
Background: Infliximab [IFX] and adalimumab [ADA] are effective in Crohn's disease [CD] for induction and maintenance therapy. However, high annual rate of discontinuation for loss of response or intolerance may lead to a switch to another anti-tumor necrosis factor agent. Patients with successive failure to IFX and ADA are becoming more frequent. ...
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Bellinger, Justine Munoz-Bongrand, Nicolas Pariente, Benjamin Baudry, Clotilde Chirica, Mircea Gornet, Jean-Marc Matthieu Allez Cattan, Pierre
Published in
Journal of Laparoendoscopic & Advanced Surgical Techniques
Background: After ileocolic resection in Crohn's disease, studies concerning the influence of the laparoscopic or open approach on clinical and endoscopic recurrences are scarce.
Patients and methods: In a prospective database, we identified all patients operated on between 2004 and 2012 for primary ileocolic resection in Crohn's disease, with a...
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Amiot, Aurelien Setakhr, Vida Seksik, Philippe Matthieu Allez Treton, Xavier De Vos, Martine Laharie, David Colombel, Jean-Frederic Abitbol, Vered Reimund, Jean Marie
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Published in
The American Journal of Gastroenterology
Objectives: Although anti-tumor necrosis factor (TNF) therapy is the treatment of choice for perianal fistulizing Crohn's disease (CD), the efficacy and safety of anti-TNF therapy in enterocutaneous fistula (ECF) remains unclear.
Methods: Between January 2008 and December 2009, we retrospectively reviewed the outcomes of all CD patients with ECF...
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Tauber, Marie Buche, Sébastien Reygagne, Pascal Berthelot, Jean-Marie Aubin, François Ghislain, Pierre-Dominique Cohen, Jean-David Coquerelle, Pascal Goujon, Elisa Jullien, Denis
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Published in
Journal of the American Academy of Dermatology
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Abraham, Julie Anne Janin Gornet, Jean-Marc Peffault de Latour, Régis Robin, Marie Xhaard, Aliénor de Fontebrune, Flore Sicre Mary, Jean Yves Matthieu Allez Porcher, Raphael
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Published in
Transplantation Journal
Clinical, histological, and endoscopic scores poorly correlated with each other when estimated at the GI-GvHD onset. However, all three severe initial scores independently predict poor outcome. Of interest, clinical and endoscopic scores predict resistance to steroids while pathological does not.
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Rajca, Sylvie Grondin, Virginie Louis, Edouard Vernier-Massouille, Gwenola Grimaud, Jean-Charle Bouhnik, Yoram Laharie, David Dupas, Jean-Louis Pillant, Helene Picon, Laurence
...
Published in
Inflammatory Bowel Diseases
BACKGROUND:: Crohn's disease (CD)-associated dysbiosis could predispose patients to relapse. Gut microbiota composition of patients from the prospective cohort study designed to identify predictive factors of clinical relapse after infliximab discontinuation (STORI Study) was investigated to determine the impact of dysbiosis in CD relapse. METHODS:...
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Guellouz, Sabra Pariente, Benjamin Benet, Claire Baudry, Clotilde Lourenco, Nelson Kraemer, Aurore Matthieu Allez Gornet, Jean-Marc
Published in
Case Reports in Gastroenterology
Upper gastrointestinal (GI) tract involvement in adult Crohn's disease (CD) is rare and severe complications unusual. Stenosis has been reported, but gastroduodenal fistulae are seldom detected during surgery and most of the fistulae are cologastric or ileogastric. In complicated gastroduodenal CD, medical treatments are often effective and surgery...
