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Seidel Carole Michael Schnekenburger Aloran Mazunder Marie-Hélène Teiten Gilbert Kirsch Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
in Jan 02, 2016
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including a-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
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Wamtinga Sawadogo Ali Al-Mourabit Céline Moriou Innocent Guissou Mario Dicato Marie-Hélène Teiten Marc Diederich
Published in
Nutrients
in Dec 25, 2015
Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. ...
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Marie-Hélène Teiten François Gaascht Mario Dicato Marc Diederich
Published in
Current Pharmaceutical Biotechnology
The aberrant activation of the wingless (Wnt) signaling pathway is a key element involved in carcinogenesis as Wnt regulates a variety of cellular processes including proliferation, differentiation, survival, apoptosis and cell motility. Upon Wnt receptor activation, the canonical "Wnt/beta-catenin" as well as the non canonical "Wnt/planar cell pol...
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Marie-Hélène Teiten Lina Bezdetnaya Patrice Morlière René Santus François Guillemin
Published in
British Journal of Cancer
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Marie-Hélène Teiten Mario Dicato Marc Diederich
Published in
Molecular Nutrition & Food Research
Epigenetic alterations correspond to changes in DNA methylation, covalent modifications of histones, or altered miRNA expression patterns. These three mechanisms are interconnected and appear to be key players in tumor progression and failure of conventional chemotherapy. Dietary components emerged as a promising source of new epigenetically active...
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Marie-Hélène Teiten Fabienne Mack Abdessamad Debbab Amal H. Aly Mario Dicato Peter Proksch Marc Diederich
Published in
Bioorganic & Medicinal Chemistry
Altersolanol A, a natural product from the endophytic fungus Stemphylium globuliferum isolated from the medicinal plant Mentha pulegium (Lamiaceae) growing in Morocco, shows cytotoxic, cytostatic, anti-inflammatory and anti-migrative activity against human chronic myeloid K562 leukemia and A549 lung cancer cells in a dose dependent manner without a...
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Marie-Hélène Teiten Anthoula Gaigneaux Sébastien Chateauvieux Anja M. Billing Sébastien Planchon Fred Fack Jenny Renaut Fabienne Mack Claude P. Muller Mario Dicato
...
Published in
OMICS A Journal of Integrative Biology
Due to high prevalence and slow progression of prostate cancer, primary prevention appears to be attractive strategy for its eradication. During the last decade, curcumin (diferuloylmethane), a natural compound from the root of turmeric (Curcuma longa), was described as a potent chemopreventive agent. Curcumin exhibits anti-inflammatory, anticarcin...
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Jean-Louis Merlin Hervé Gautier Muriel Barberi-Heyob Marie-Hélène Teiten François Guillemin
Published in
International Journal of Oncology
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Wamtinga Sawadogo Rainatou Boly Claudia Cerella Marie-Hélène Teiten Mario Dicato Marc Diederich
Published in
Molecules
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Tom Juncker Claudia Cerella Marie-Hélène Teiten Franck Morceau Marc Schumacher Jenny Ghelfi François Gaascht Michael Schnekenburger Estelle Henry Mario Dicato
...
Published in
Biochemical Pharmacology
Cardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to investigate the anti-leukemic activity of UNBS1450, a hemi-synthetic cardenolide belonging to the cardiac steroid glycoside family. Here, we report that, at low nanomolar concentrations, UNBS1450 induces apoptotic cell dea...
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Jenny Ghelfi Francois Gaascht Claudia Cerella Marie-Hélène Teiten Mario Dicato Marc Diederich Tom Juncker Marc Schumacher Michael Schnekenburger Estelle Henry
...
Published in
Biochemical Pharmacology
Cardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to investigate the anti-leukemic activity of UNBS1450, a hemi-synthetic cardenolide belonging to the cardiac steroid glycoside family. Here, we report that, at low nanomolar concentrations, UNBS1450 induces apoptotic cell dea...
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Marie-Hélène Teiten Serge Eifes Simone Reuter Annelyse Duvoix Mario Dicato Marc Diederich
Published in
Annals of the New York Academy of Sciences
A strong relationship exists between inflammation and carcinogenesis. To bring insights into the anti-inflammatory mechanisms by which chemopreventive agents, such as curcumin, are able to counteract the action of inflammation mediators, such as tumor necrosis factor-alpha (TNF-alpha), we compared gene expression profiles in K562 cells treated with...
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Marie-Hélène Teiten Simone Reuter Stéphane Schmucker Mario Dicato Marc Diederich
Published in
Cancer Letters
Heat shock response is an adaptive response, which helps the cells to regulate their physiological homeostasis under stress. Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 pr...
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Marie-Hélène Teiten Serge Eifes Mario Dicato Marc Diederich
Published in
Toxins
As cancer is a multifactor disease, it may require treatment with compounds able to target multiple intracellular components. We summarize here how curcumin is able to modulate many components of intracellular signaling pathways implicated in inflammation, cell proliferation and invasion and to induce genetic modulations eventually leading to tumor...
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François Gaascht Marie-Hélène Teiten Claudia Cerella Mario Dicato Denyse Bagrel Marc Diederich
Published in
Molecules
Plumbagin is a plant naphtoquinone exerting anti-cancer properties including apoptotic cell death induction and generation of reactive oxygen species (ROS). The aim of this study was to elucidate parameters explaining the differential leukemia cell sensitivity towards this compound. Among several leukemia cell lines, U937 monocytic leukemia cells a...
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Wamtinga Richard Sawadogo Marc Schumacher Marie-Hélène Teiten Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
Traditional pharmacopeia is strongly involved in the continuous search for the well being of African populations. The World Health Organization (WHO) estimates that 80% of the population of developing countries relies on traditional medicine for their primary care needs. Medicinal plants are the major resource of this folk medicine where several sp...
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Shéhérazade Hajjouli Sébastien Chateauvieux Marie-Hélène Teiten Barbora Orlikova Marc Schumacher Mario Dicato Chee-Yan Choo Marc Diederich
Published in
Molecules
Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viabili...
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Simone Reuter Jessica Charlet Tom Juncker Marie-Hélène Teiten Mario Dicato Marc Diederich
Published in
Annals of the New York Academy of Sciences
Curcumin, a natural product isolated from the plant Curcuma longa, has a diverse range of molecular targets that influence numerous biochemical and molecular cascades. Curcumin has been shown to inhibit nuclear factor kappaB (NF-kappaB) activation at several steps in the NF-kappaB signaling pathways and thereby controls numerous NF-kappaB-regulated...
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Simone Reuter Michael Schnekenburger Silvia Cristofanon Isabelle Buck Marie-Hélène Teiten Sandrine Daubeuf Serge Eifes Mario Dicato Bharat B. Aggarwal Athanase Visvikis
...
Published in
Biochemical Pharmacology
γ-Glutamyltransferase (GGT) cleaves the γ-glutamyl moiety of glutathione (GSH), an endogenous antioxidant, and is involved in mercapturic acid metabolism and in cancer drug resistance when overexpressed. Moreover, GGT converts leukotriene (LT) C4 into LTD4 implicated in various inflammatory pathologies. So far the effect of inflammatory stimuli o...
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Weaam Ebrahim Amal H. Aly Victor Wray Attila Mándi Marie-Hélène Teiten François Gaascht Barbora Orlikova Matthias U. Kassack Wenhan Lin Marc Diederich
...
Published in
Journal of Medicinal Chemistry
Two new metabolites, embellicines A and B (1 and 2), were isolated from the EtOAc extract of the fungus Embellisia eureka, an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of extensive one- and two-dimensional NMR spectroscopy as well as by high-resolution mass s...
