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Seidel, Carole Marc Diederich Mazumder, Aloran Kirsch, Gilbert Dicato, Mario Michael Schnekenburger Marie-Hélène Teiten
Published in
Biochemical Pharmacology
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including α-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
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Sawadogo, Wamtinga Al-Mourabit, Ali Moriou, Céline Guissou, Innocent Dicato, Mario Marie-Hélène Teiten Marc Diederich
Published in
Nutrients
Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. ...
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Hajjouli, Shéhérazade Sébastien Chateauvieux Marie-Hélène Teiten Barbora Orlikova Schumacher, Marc Dicato, Mario Choo, Chee-Yan Marc Diederich
Published in
Molecules
Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viabili...
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Francois Gaascht Marie-Hélène Teiten Claudia Cerella Dicato, Mario Bagrel, Denyse Marc Diederich
Published in
Molecules
Plumbagin is a plant naphtoquinone exerting anti-cancer properties including apoptotic cell death induction and generation of reactive oxygen species (ROS). The aim of this study was to elucidate parameters explaining the differential leukemia cell sensitivity towards this compound. Among several leukemia cell lines, U937 monocytic leukemia cells a...
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Marie-Hélène Teiten Francois Gaascht Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Since centuries, natural compounds from plants, animals and microorganisms were used in medicinal traditions to treat various diseases without a solid scientific basis. Recent studies have shown that plants that were used or are still used in the medieval European medicine are able to provide relieve for many diseases including cancer. Here we summ...
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Ebrahim, Weaam Aly, Amal H. Wray, Victor Mándi, Attila Marie-Hélène Teiten Francois Gaascht Barbora Orlikova Kassack, Matthias U. Lin, Wenhan Marc Diederich
...
Published in
Journal of Medicinal Chemistry
Two new metabolites, embellicines A and B (1 and 2), were isolated from the EtOAc extract of the fungus Embellisia eureka, an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of extensive one- and two-dimensional NMR spectroscopy as well as by high-resolution mass s...
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Marie-Hélène Teiten Mack, Fabienne Debbab, Abdessamad Aly, Amal H. Dicato, Mario Proksch, Peter Marc Diederich
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Bioorganic & Medicinal Chemistry
Altersolanol A, a natural product from the endophytic fungus Stemphylium globuliferum isolated from the medicinal plant Mentha pulegium (Lamiaceae) growing in Morocco, shows cytotoxic, cytostatic, anti-inflammatory and anti-migrative activity against human chronic myeloid K562 leukemia and A549 lung cancer cells in a dose dependent manner without a...
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Marie-Hélène Teiten Dicato, Mario Marc Diederich
Published in
Molecular Nutrition & Food Research
Epigenetic alterations correspond to changes in DNA methylation, covalent modifications of histones, or altered miRNA expression patterns. These three mechanisms are interconnected and appear to be key players in tumor progression and failure of conventional chemotherapy. Dietary components emerged as a promising source of new epigenetically active...
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Sawadogo, Wamtinga Schumacher, Marc Dicato, Mario Marc Diederich Claudia Cerella Marie-Hélène Teiten
Published in
Molecules
Cancer continues to be a major public health problem despite the efforts that have been made in the search for novel drugs and treatments. The current sources sought for the discovery of new molecules are plants, animals and minerals. During the past decade, the search for anticancer agents of marine origin to fight chemo-resistance has increased g...
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Richard Sawadogo, Wamtinga Schumacher, Marc Marie-Hélène Teiten Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Traditional pharmacopeia is strongly involved in the continuous search for the well being of African populations. The World Health Organization (WHO) estimates that 80% of the population of developing countries relies on traditional medicine for their primary care needs. Medicinal plants are the major resource of this folk medicine where several sp...
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Marie-Hélène Teiten Anthoula Gaigneaux Sébastien Chateauvieux Billing, Anja M. Planchon, Sébastien Fack, Fred Renaut, Jenny Mack, Fabienne Muller, Claude P. Dicato, Mario
...
Published in
OMICS A Journal of Integrative Biology
Due to high prevalence and slow progression of prostate cancer, primary prevention appears to be attractive strategy for its eradication. During the last decade, curcumin (diferuloylmethane), a natural compound from the root of turmeric (Curcuma longa), was described as a potent chemopreventive agent. Curcumin exhibits anti-inflammatory, anticarcin...
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Marie-Hélène Teiten Francois Gaascht Dicato, Mario Marc Diederich
Published in
Current Pharmaceutical Biotechnology
The aberrant activation of the wingless (Wnt) signaling pathway is a key element involved in carcinogenesis as Wnt regulates a variety of cellular processes including proliferation, differentiation, survival, apoptosis and cell motility. Upon Wnt receptor activation, the canonical "Wnt/beta-catenin" as well as the non canonical "Wnt/planar cell pol...
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Marie-Hélène Teiten Francois Gaascht Cronauer, Marcus Henry, Estelle Dicato, Mario Marc Diederich
Published in
International Journal of Oncology
Activation of the Wingless (Wnt)/ß-catenin signaling pathway contributes to prostate tumorigenesis and metastasis. Depending of the stage of prostate cancer development, current drug therapies are of limited efficiency, so that prevention with natural compounds appears as an attractive strategy especially due to the slow progressive development of ...
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Marie-Hélène Teiten Eifes, Serge Dicato, Mario Marc Diederich
Published in
Toxins
As cancer is a multifactor disease, it may require treatment with compounds able to target multiple intracellular components. We summarize here how curcumin is able to modulate many components of intracellular signaling pathways implicated in inflammation, cell proliferation and invasion and to induce genetic modulations eventually leading to tumor...
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Marie-Hélène Teiten Francois Gaascht Eifes, Serge Dicato, Mario Marc Diederich
Published in
Genes & Nutrition
The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention in order to prevent or eradicate prostate malignancies. We present here an overview of the chemopreventive potential of curcumin (diferuloylmethane), a well-known natural compound that exhibits therapeutic promise for prostate c...
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Reuter, Simone Charlet, Jessica Juncker, Tom Marie-Hélène Teiten Dicato, Mario Marc Diederich
Published in
Annals of the New York Academy of Sciences
Curcumin, a natural product isolated from the plant Curcuma longa, has a diverse range of molecular targets that influence numerous biochemical and molecular cascades. Curcumin has been shown to inhibit nuclear factor kappaB (NF-kappaB) activation at several steps in the NF-kappaB signaling pathways and thereby controls numerous NF-kappaB-regulated...
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Marie-Hélène Teiten Eifes, Serge Reuter, Simone Duvoix, Annelyse Dicato, Mario Marc Diederich
Published in
Annals of the New York Academy of Sciences
A strong relationship exists between inflammation and carcinogenesis. To bring insights into the anti-inflammatory mechanisms by which chemopreventive agents, such as curcumin, are able to counteract the action of inflammation mediators, such as tumor necrosis factor-alpha (TNF-alpha), we compared gene expression profiles in K562 cells treated with...
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Marie-Hélène Teiten Reuter, Simone Schmucker, Stéphane Dicato, Mario Marc Diederich
Published in
Cancer Letters
Heat shock response is an adaptive response, which helps the cells to regulate their physiological homeostasis under stress. Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 pr...
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Reuter, Simone Michael Schnekenburger Cristofanon, Silvia Buck, Isabelle Marie-Hélène Teiten sandrine daubeuf Eifes, Serge Dicato, Mario Aggarwal, Bharat B. Visvikis, Athanase
...
Published in
Biochemical Pharmacology
γ-Glutamyltransferase (GGT) cleaves the γ-glutamyl moiety of glutathione (GSH), an endogenous antioxidant, and is involved in mercapturic acid metabolism and in cancer drug resistance when overexpressed. Moreover, GGT converts leukotriene (LT) C4 into LTD4 implicated in various inflammatory pathologies. So far the effect of inflammatory stimuli on ...
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Tom Juncker Claudia Cerella Marie-Hélène Teiten Franck Morceau Marc Schumacher Jenny Ghelfi François Gaascht Michael Schnekenburger Estelle Henry Mario Dicato
...
Published in
Biochemical Pharmacology
Cardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to investigate the anti-leukemic activity of UNBS1450, a hemi-synthetic cardenolide belonging to the cardiac steroid glycoside family. Here, we report that, at low nanomolar concentrations, UNBS1450 induces apoptotic cell dea...
