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Michael Schnekenburger Eric Goffin Jin-Young Lee Jun Young Jang Aloran Mazumder Seungwon Ji Bernard Rogister Nafila Bouider Florence Lefranc Walter Miklos
...
Published in
Journal of Medicinal Chemistry
in May 08, 2017
A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. Based on computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyano...
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Marc Diederich Claudia Cerella
Published in
Seminars in Cancer Biology
in May 31, 2016
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Seidel Carole Michael Schnekenburger Aloran Mazunder Marie-Hélène Teiten Gilbert Kirsch Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
in Jan 02, 2016
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including a-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
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Wamtinga Sawadogo Ali Al-Mourabit Céline Moriou Innocent Guissou Mario Dicato Marie-Hélène Teiten Marc Diederich
Published in
Nutrients
in Dec 25, 2015
Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. ...
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Festus B.C. Okoye Wamtinga Richard Sawadogo Jandirk Sendker Amal H. Aly Bettina Quandt Victor Wray Andreas Hensel Charles O. Esimone Abdessamad Debbab Marc Diederich
...
Published in
Journal of Ethnopharmacology
in Dec 18, 2015
Ethnopharmacological relevance: Olax mannii Oliv. (Olacaceae) is among the many medicinal plants used in Nigeria for the ethnomedicinal management of both cancer and inflammation. Such plants represent potential sources of innovative therapeutic agents for the treatment of cancer and other malignant disorders. While the majority of medicinal plants...
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C. Sobolewski J. Rhim N. Legrand F. Muller C. Cerella F. Mack S. Chateauvieux J.-G. Kim A.-Y. Yoon K.-W. Kim
...
Published in
Journal of Pharmacology and Experimental Therapeutics
in Aug 31, 2015
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Claudia Cerella Florian Muller Anthoula Gaigneaux Flavia Radogna Elodie Viry Sébastien Chateauvieux Mario Dicato Marc Diederich
Published in
Cell Death and Disease
in Jun 07, 2015
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na + /K +)-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis ...
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Cindy Grandjenette Michael Schnekenburger Franck Morceau Fabienne Mack Katja Wiechmann Oliver Werz Mario Dicato Marc Diederich
Published in
Anti-Cancer Agents in Medicinal Chemistry
in Jan 11, 2015
Despite recent advances in the treatment of chronic myelogenous leukemia (CML), the development of drug resistance and minimal residual disease remain major challenges for the treatment of CML patients, thus highlighting the need to develop innovative new approaches to improve therapeutic outcome. Myrtucommulone A (MCA) is a nonprenylated acylphlor...
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Franck Morceau Sébastien Chateauvieux Anthoula Gaigneaux Mario Dicato Marc Diederich
Published in
International Journal of Molecular Sciences
in Jul 10, 2013
Genomic analyses estimated that the proportion of the genome encoding proteins corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that many non-coding DNA-regions generate non-coding RNAs (ncRNAs). The relevance of these ncRNAs in biological, physiological as well as in pathological processes increased over the last t...
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Daniel J Klionsky Marc Diederich
Published in
Autophagy
in Apr 17, 2012
Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for 2100 reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines
are not meant to be a formulaic s...
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Jenny Ghelfi Francois Gaascht Claudia Cerella Marie-Hélène Teiten Mario Dicato Marc Diederich Tom Juncker Marc Schumacher Michael Schnekenburger Estelle Henry
...
Published in
Biochemical Pharmacology
Cardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to investigate the anti-leukemic activity of UNBS1450, a hemi-synthetic cardenolide belonging to the cardiac steroid glycoside family. Here, we report that, at low nanomolar concentrations, UNBS1450 induces apoptotic cell dea...
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Claudia Cerella Marc Diederich Lina Ghibelli
Published in
International Journal of Cell Biology
Ca(2+) is an important second messenger participating in many cellular activities; when physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor, producing/increasing cell damage. Damage elicits both repair and death responses; intriguingly, in those responses Ca(2+) also participates as second messenger. This d...
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M. Kelkel Claudia Cerella F. Mack T. Schneider C. Jacob M. Schumacher M. Dicato Marc Diederich
Published in
Carcinogenesis
Garlic-derived organosulfur compounds including diallyl polysulfides are well known for various health-beneficial properties and recent reports even point to a potential role of diallyl polysulfides as chemopreventive and therapeutic agents in cancer treatment due to their selective antiproliferative effects. In this respect, diallyl tri- and tetra...
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Silvia Cristofanon Mario Dicato Lina Ghibelli Marc Diederich
Published in
Redox Signaling and Regulation in Biology and Medicine
The decision of a cell to die is triggered by the imbalance between the positive signals,
those needed for continuing to survive (i.e. growth factors), and negative signals
(i.e. DNA damages, increased levels of oxidants) [1]. There are two major mechanisms
of cell death: necrosis and apoptosis. The severity of the injury leads the cells to decide
...
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F. Folmer M. Dicato Marc Diederich
Published in
Current Topics in Medicinal Chemistry
TNF-α was discovered more then 20 years ago as a cytokine implicated in a wide range of cell signaling pathways, many of which are known to lead to the activation of genes involved in inflammation and carcinogenesis. TNF-α is involved in the pathogenesis of many diseases, including Crohn's disease, diabetes, septic shock, tumorigenesis, rheumatoi...
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Claudia Cerella Cyril Sobolewski Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
Cyclooxygenase (COX)-2 is a pro-inflammatory immediate early response protein, chronically up-regulated in many pathological conditions. In autoimmune diseases, it is responsible for degenerative effects whereas in cancer, it correlates with poor prognosis. A constitutive expression of COX-2 is triggered since the earliest steps of carcinogenesis. ...
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Franck Morceau Annelyse Duvoix Sylvie Delhalle Michael Schnekenburger Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
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Cyril Sobolewski Florian Muller Claudia Cerella Mario Dicato Marc Diederich
Published in
Molecular Carcinogenesis
Molecules targeting pro-inflammatory pathways have demonstrated beneficial effects in cancer treatment. More recently, combination of natural and synthetic anti-inflammatory drugs was suggested as an appealing strategy to inhibit tumor growth. Herein, we show that curcumin, a polyphenol from Curcuma longa and celecoxib induce apoptosis in hematopoi...
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Barbora Orlikova José C.J.M.D.S. Menezes Seungwon Ji Shrivallabh P. Kamat José A.S. Cavaleiro Marc Diederich
Published in
European Journal of Medicinal Chemistry
A new series of chalcones, flavanones and flavones with methylenedioxy group at the 3',4' position in chalcone, 7,8 position in flavanones and flavones with mono-, di- and trimethoxy groups in the benzaldehyde ring have been assessed for their effect on proliferation, cytotoxic potential and apoptosis in human leukemia cells. Among the tested compo...
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Michael Schnekenburger Mario Dicato Seidel Carole Marc Diederich
Published in
Biochimie
Epigenetic alterations are involved in every step of carcinogenesis. The development of chromatin- modifying agents (CMAs) has provided the ability to fight cancer by reversing these alterations. Currently, four CMAs have been approved for cancer treatment; two DNA demethylating agents and two deacetylase inhibitors. A number of promising CMAs are ...
