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Marie-Hélène Teiten Dicato, Mario Marc Diederich
Published in
Molecular Nutrition & Food Research
Epigenetic alterations correspond to changes in DNA methylation, covalent modifications of histones, or altered miRNA expression patterns. These three mechanisms are interconnected and appear to be key players in tumor progression and failure of conventional chemotherapy. Dietary components emerged as a promising source of new epigenetically active...
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Marc Diederich Gelderblom, H. Slingerland, M. Claudia Cerella Guchelaar, H. J.
Published in
Investigational New Drugs
Cardiac glycosides have a long history in the treatment of cardiac disease. However, several preclinical studies as well as two phase I studies have shown that cardenolides may also possess anticancer effects. The mechanisms of these anticancer effects may include intracellular decrease of K(+) and increase of Na(+) and Ca(2+); intracellular acidif...
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Dicato, Mario Claudia Cerella Marc Diederich
Published in
Mitochondrion
Cardiac glycosides (CGs) are compounds used for the treatment of cardiac failure which also display strong anti-cancer activity inducing impairment of cell proliferation or activation of cell death whether by apoptosis or autophagy. Despite the fact that the sodium/potassium (Na(+)/K(+))-ATPase is a well-known target of CGs, its involvement in the ...
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Kopf, Sabine Viola, Katharina Atanas G. Atanasov Jarukamjorn, Kanokwan Rarova, Lucie Kretschy, Nicole Teichmann, Mathias Vonach, Caroline Saiko, Philipp Giessrigl, Benedikt
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Published in
Archives of Toxicology
Metastases destroy the function of infested organs and are the main reason of cancer-related mortality. Heteronemin, a natural product derived from a marine sponge, was tested in vitro regarding its properties to prevent tumour cell intravasation through the lymph-endothelial barrier. In three-dimensional (3D) cell cultures consisting of MCF-7 brea...
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Sawadogo, Wamtinga Schumacher, Marc Dicato, Mario Marc Diederich Claudia Cerella Marie-Hélène Teiten
Published in
Molecules
Cancer continues to be a major public health problem despite the efforts that have been made in the search for novel drugs and treatments. The current sources sought for the discovery of new molecules are plants, animals and minerals. During the past decade, the search for anticancer agents of marine origin to fight chemo-resistance has increased g...
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Poplineau, Mathilde Doliwa, C. Michael Schnekenburger Antonicelli, Frank Marc Diederich Trussardi-Régnier, Aurélie Dufer, Jean
Published in
Cell Proliferation
Chromatin texture patterns of tumour cell nuclei can serve as cancer biomarkers, either to define diagnostic classifications or to obtain relevant prognostic information, in a large number of human tumours. Epigenetic mechanisms, mainly DNA methylation and histone post-translational modification, have been shown to influence chromatin packing state...
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Richard Sawadogo, Wamtinga Schumacher, Marc Marie-Hélène Teiten Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Traditional pharmacopeia is strongly involved in the continuous search for the well being of African populations. The World Health Organization (WHO) estimates that 80% of the population of developing countries relies on traditional medicine for their primary care needs. Medicinal plants are the major resource of this folk medicine where several sp...
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Sibille, Estelle Bana, Emilie Chaouni, Wafaa Marc Diederich Bagrel, Denyse Chaimbault, Patrick
Published in
Analytical Biochemistry
The cell division cycle 25 phosphatases (CDC25s) are key regulators of the physiological cell cycle progression. Their overexpression has been reported in a significant number of cancers, and their inhibition appears to be an interesting strategy for treatments. We propose here a rapid screening test allowing the detection of reversible and irrever...
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Cristina Florean Marc Diederich
Published in
Biochemical Pharmacology
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Michael Schnekenburger Cristina Florean Dicato, Mario Seidel Carole Marc Diederich
Published in
Biochimie
Epigenetic alterations are involved in every step of carcinogenesis. The development of chromatin- modifying agents (CMAs) has provided the ability to fight cancer by reversing these alterations. Currently, four CMAs have been approved for cancer treatment; two DNA demethylating agents and two deacetylase inhibitors. A number of promising CMAs are ...
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Marc Diederich
Published in
Cell Cycle
Comment on: Pietrocola, et al. Cell Cycle 2012; 11:3851-60.
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Folmer, Florence Dicato, Mario Marc Diederich
Published in
Current Topics in Medicinal Chemistry
TNF-α was discovered more then 20 years ago as a cytokine implicated in a wide range of cell signaling pathways, many of which are known to lead to the activation of genes involved in inflammation and carcinogenesis. TNF-α is involved in the pathogenesis of many diseases, including Crohn's disease, diabetes, septic shock, tumorigenesis, rheumatoid ...
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Kelkel, Mareike Claudia Cerella Mack, Fabienne Schneider, Carolin Jacob, Claus Schumacher, Marc Dicato, Mario Marc Diederich
Published in
Carcinogenesis
Garlic-derived organosulfur compounds including diallyl polysulfides are well known for various health-beneficial properties and recent reports even point to a potential role of diallyl polysulfides as chemopreventive and therapeutic agents in cancer treatment due to their selective antiproliferative effects. In this respect, diallyl tri- and tetra...
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Marie-Hélène Teiten Anthoula Gaigneaux Sébastien Chateauvieux Billing, Anja M. Planchon, Sébastien Fack, Fred Renaut, Jenny Mack, Fabienne Muller, Claude P. Dicato, Mario
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Published in
OMICS A Journal of Integrative Biology
Due to high prevalence and slow progression of prostate cancer, primary prevention appears to be attractive strategy for its eradication. During the last decade, curcumin (diferuloylmethane), a natural compound from the root of turmeric (Curcuma longa), was described as a potent chemopreventive agent. Curcumin exhibits anti-inflammatory, anticarcin...
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Karius, Tommy Michael Schnekenburger Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
MicroRNAs (miRNAs) represent a class of small (21–23 nucleotides) non-coding RNAs that emerged as key post-transcriptional gene regulators, implicated in numerous physiological and pathological processes. Currently, a main focus of miRNA research is related to the roles of miRNAs in cancer development. The biogenesis and modes of action of miRNAs h...
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Zwergel, Clemens Francois Gaascht Valente, Sergio Marc Diederich Bagrel, Denyse Kirsch, Gilbert
Published in
ChemInform
Aurones [2-benzylidenebenzofuran-3(2H)-ones] are either natural or synthetic compounds, belonging to the flavonoid family. They are isomeric to flavones and provide a bright yellow color to the plants in which they occur. Today, a literature survey indicates that the related flavonoids have been studied not only for their physiological properties a...
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Charlet, Jessica Michael Schnekenburger Brown, Keith W. Marc Diederich
Published in
Biochemical Pharmacology
Neuroblastoma is a common embryonal malignancy in which high-stage cases have a poor prognosis, often associated with resistance to chemotherapeutic drugs. DNA methylation alterations are frequent in neuroblastoma and can modulate sensitivity to chemotherapeutic drugs in other cancers, suggesting that manipulation of epigenetic modifications could ...
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Klionsky, Daniel J. Marc Diederich
Published in
Autophagy
Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for 2100 reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic se...
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Klionsky, Daniel J. Marc Diederich
Published in
Autophagy
Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for 2100 reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic se...
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Schumacher, Marc Wilson, Neil Tabudravu, Jioji N. Edwards, Christine Lawton, Linda A. Motti, Cherie Wright, Anthony D. Marc Diederich Jaspars, Marcel
Published in
Tetrahedron
Investigation of aqueous methanol extracts of the cyanobacterium Nodularia spumigena KAC 66 led to the isolation of the nodulopeptins 899, 901 and 917. The chemical structures were determined using high-resolution NMR and MS-data. The stereochemistry of the amino-acid residues was realized by LC–MS analysis using Marfey’s reagent. The bioactivity o...