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Rönsberg, David Debbab, Abdessamad Mándi, Attila Vasylyeva, Vera Böhler, Philip Stork, Björn Engelke, Laura Hamacher, Alexandra Sawadogo, Richard Marc Diederich
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Published in
The Journal of Organic Chemistry
Four tetrahydroxanthone dimers (1-4) and four biogenetically related monomers (5-8), including the new derivatives (4-6), were isolated from the endophyte Phomopsis longicolla. The absolute configurations of 2-4 were established for the first time by TDDFT ECD calculations and that of phomoxanthone A (1) was revised by X-ray crystallography. Phomox...
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Colin-Cassin, Christelle Yao, Xiao Claudia Cerella Chbicheb, Sarra Kuntz, Sandra Mazerbourg, Sabine Boisbrun, Michel Chapleur, Yves Marc Diederich Flament, Stephane
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Published in
Molecular Carcinogenesis
Our aim was to better understand peroxisome proliferator-activated receptor gamma (PPARγ)-independent pathways involved in anti-cancer effects of thiazolidinediones (TZDs). We focused on Δ2-troglitazone (Δ2-TGZ), a PPARγ inactive TZD that affects breast cancer cell viability. Appearance of TUNEL positive cells, changes in mitochondrial membrane pot...
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Marie-Hélène Teiten Francois Gaascht Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Since centuries, natural compounds from plants, animals and microorganisms were used in medicinal traditions to treat various diseases without a solid scientific basis. Recent studies have shown that plants that were used or are still used in the medieval European medicine are able to provide relieve for many diseases including cancer. Here we summ...
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Bana, Emilie Sibille, Estelle Valente, Sergio Claudia Cerella Chaimbault, Patrick Kirsch, Gilbert Dicato, Mario Marc Diederich Bagrel, Denyse
Published in
Molecular Carcinogenesis
Cell division cycle (CDC) 25 proteins are key phosphatases regulating cell cycle transition and proliferation by regulating CDK/cyclin complexes. Overexpression of these enzymes is frequently observed in cancer and is related to aggressiveness, high-grade tumors and poor prognosis. Thus, targeting CDC25 by compounds, able to inhibit their activity,...
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Trécul, Anne Franck Morceau Anthoula Gaigneaux Marion Orsini Sébastien Chateauvieux Cindy Grandjenette Dicato, Mario Marc Diederich
Published in
Cancer Letters
Constitutive activity of kinases has been reported in many types of cancers, so that inhibition of "onco-kinases" became a validated anti-cancer strategy. We found that the polyphenol 13c, a tri-vanillate derivative, inhibited kinase phosphorylation in leukemia cells. P-JAK2, P-Src and P-PI3Kp85 inhibition occurred independently of phosphatase invo...
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Barbora Orlikova Legrand, Noémie Panning, Jana Dicato, Mario Marc Diederich
Published in
Cancer Treatment and Research
Over the centuries, plant extracts have been used to treat various diseases. Until now, natural products have played an important role in anticancer therapy as there are more than 500 compounds from terrestrial and marine plants or microorganisms, which have antioxidant, antiproliferative, or antiangiogenic properties and are therefore able to redu...
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Barbora Orlikova Schumacher, Marc Juncker, Tom Chee Yan, Choo Inayat-Hussain, Salmaan H. Hajjouli, Shéhérazade Claudia Cerella Dicato, Mario Marc Diederich
Published in
Food and Chemical Toxicology
(R)-(+)-Goniothalamin (GTN), a styryl-lactone isolated from the medicinal plant Goniothalamus macrophyllus, exhibits pharmacological activities including cytotoxic and anti-inflammatory effects. In this study, GTN modulated TNF-α induced NF-κB activation. GTN concentrations up to 20 μM showed low cytotoxic effects in K562 chronic myelogenous leukem...
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Folmer, Florence Basavaraju, Umesh Jaspars, Marcel Hold, Georgina El-Omar, Emad Dicato, Mario Marc Diederich
Published in
Phytochemistry Reviews
In the present review, we describe chemical and chemopreventive properties as well as health benefits of both extracts and bioactive compounds from various types of berries including small soft-fleshed edible berries and from berry-like fruits such as strawberries, raspberries, blackberries, blueberries, mulberries, currants, gooseberries, elderber...
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Poplineau, Mathilde Michael Schnekenburger Dufer, Jean Kosciarz, Aleksandra Brassart-Pasco, Sylvie Antonicelli, Frank Marc Diederich Trussardi-Régnier, Aurélie
Published in
Molecular Carcinogenesis
In diseases such as cancer, cells need to degrade the extracellular matrix (ECM) and therefore require high protease levels. Thus, aberrant tissue degradation is associated to matrix metalloproteinases (MMPs) overexpression resulting from different mechanisms including epigenetic events. One of the most characterized epigenetic mechanisms is DNA me...
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Barbora Orlikova Dicato, Mario Marc Diederich
Published in
Phytochemistry Reviews
Over the past decades, apoptosis emerged as a leading strategy to eliminate cancer cells. Nowadays, it becomes progressively clear that apoptosis is not the only programmed cell death mechanism implicated in the elimination of malignant cells. This review will discuss non-apoptotic cell death modalities and will focus on natural compounds acting as...
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Claudia Cerella Michiels, Carine Dashwood, Roderick H. Surh, Young-joon Marc Diederich
Published in
International Journal of Cell Biology
Hindawi Publishing Corporation International Journal of Cell Biology Volume 2013, Article ID 293201, 2 pages http://dx.doi.org/10.1155/2013/293201 Editorial Metabolism and Cancer: Old and New Players Claudia Cerella,1 Carine Michiels,2 Roderick H. Dashwood,3 Young-Joon Surh,4 and Marc Diederich4 1 Laboratoire de Biologie Mole´culaire et Cellulaire ...
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Francois Gaascht Dicato, Mario Marc Diederich
Published in
Frontiers in Oncology
Chemoprevention uses natural or synthetic molecules without toxic effects to prevent and/or block emergence and development of diseases including cancer. Many of these natural molecules modulate mitogenic signals involved in cell survival, apoptosis, cell cycle regulation, angiogenesis, or on processes involved in the development of metastases occu...
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Ebrahim, Weaam Aly, Amal H. Wray, Victor Mándi, Attila Marie-Hélène Teiten Francois Gaascht Barbora Orlikova Kassack, Matthias U. Lin, Wenhan Marc Diederich
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Published in
Journal of Medicinal Chemistry
Two new metabolites, embellicines A and B (1 and 2), were isolated from the EtOAc extract of the fungus Embellisia eureka, an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of extensive one- and two-dimensional NMR spectroscopy as well as by high-resolution mass s...
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Marie-Hélène Teiten Mack, Fabienne Debbab, Abdessamad Aly, Amal H. Dicato, Mario Proksch, Peter Marc Diederich
Published in
Bioorganic & Medicinal Chemistry
Altersolanol A, a natural product from the endophytic fungus Stemphylium globuliferum isolated from the medicinal plant Mentha pulegium (Lamiaceae) growing in Morocco, shows cytotoxic, cytostatic, anti-inflammatory and anti-migrative activity against human chronic myeloid K562 leukemia and A549 lung cancer cells in a dose dependent manner without a...
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Abdullah, Norkamilah Sahibul-Anwar, Hamidah Ideris, Sharinah Hasuda, Tomoyo Hitotsuyanagi, Yukio Takeya, Koichi Marc Diederich Choo, Cheeyan
Published in
Fitoterapia
Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G.macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from this extracts afforded six compou...
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De Bosscher, Karolien Beck, Ilse M. Dejager, Lien Bougarne, Nadia Anthoula Gaigneaux Sébastien Chateauvieux Ratman, Dariusz Bracke, Marc Tavernier, Jan Vanden Berghe, Wim
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Published in
Cellular and Molecular Life Sciences
Glucocorticoids (GCs) block inflammation via interference of the liganded glucocorticoid receptor (GR) with the activity of pro-inflammatory transcription factors NF-κB and AP-1, a mechanism known as transrepression. This mechanism is believed to involve the activity of GR monomers. Here, we explored how the GR monomer-favoring Compound A (CpdA) af...
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Marie-Hélène Teiten Dicato, Mario Marc Diederich
Published in
Molecular Nutrition & Food Research
Epigenetic alterations correspond to changes in DNA methylation, covalent modifications of histones, or altered miRNA expression patterns. These three mechanisms are interconnected and appear to be key players in tumor progression and failure of conventional chemotherapy. Dietary components emerged as a promising source of new epigenetically active...
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Marc Diederich Gelderblom, H. Slingerland, M. Claudia Cerella Guchelaar, H. J.
Published in
Investigational New Drugs
Cardiac glycosides have a long history in the treatment of cardiac disease. However, several preclinical studies as well as two phase I studies have shown that cardenolides may also possess anticancer effects. The mechanisms of these anticancer effects may include intracellular decrease of K(+) and increase of Na(+) and Ca(2+); intracellular acidif...
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Dicato, Mario Claudia Cerella Marc Diederich
Published in
Mitochondrion
Cardiac glycosides (CGs) are compounds used for the treatment of cardiac failure which also display strong anti-cancer activity inducing impairment of cell proliferation or activation of cell death whether by apoptosis or autophagy. Despite the fact that the sodium/potassium (Na(+)/K(+))-ATPase is a well-known target of CGs, its involvement in the ...
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Kopf, Sabine Viola, Katharina Atanas G. Atanasov Jarukamjorn, Kanokwan Rarova, Lucie Kretschy, Nicole Teichmann, Mathias Vonach, Caroline Saiko, Philipp Giessrigl, Benedikt
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Published in
Archives of Toxicology
Metastases destroy the function of infested organs and are the main reason of cancer-related mortality. Heteronemin, a natural product derived from a marine sponge, was tested in vitro regarding its properties to prevent tumour cell intravasation through the lymph-endothelial barrier. In three-dimensional (3D) cell cultures consisting of MCF-7 brea...
