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Emilie Bana Estelle Sibille Sergio Valente Claudia Cerella Patrick Chaimbault Gilbert Kirsch Mario Dicato Marc Diederich Denyse Bagrel
Published in
Molecular Carcinogenesis
Cell division cycle (CDC) 25 proteins are key phosphatases regulating cell cycle transition and proliferation by regulating CDK/cyclin complexes. Overexpression of these enzymes is frequently observed in cancer and is related to aggressiveness, high-grade tumors and poor prognosis. Thus, targeting CDC25 by compounds, able to inhibit their activity,...
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Francois Gaascht Mario Dicato Marc Diederich
Published in
Frontiers in Oncology
Chemoprevention uses natural or synthetic molecules without toxic effects to prevent and/or block emergence and development of diseases including cancer. Many of these natural molecules modulate mitogenic signals involved in cell survival, apoptosis, cell cycle regulation, angiogenesis, or on processes involved in the development of metastases occu...
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Anne Trécul Franck Morceau Anthoula Gaigneaux Marion Orsini Sébastien Chateauvieux Cindy Grandjenette Mario Dicato Marc Diederich
Published in
Cancer Letters
Constitutive activity of kinases has been reported in many types of cancers, so that inhibition of "onco-kinases" became a validated anti-cancer strategy. We found that the polyphenol 13c, a tri-vanillate derivative, inhibited kinase phosphorylation in leukemia cells. P-JAK2, P-Src and P-PI3Kp85 inhibition occurred independently of phosphatase invo...
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Weaam Ebrahim Amal H. Aly Victor Wray Attila Mándi Marie-Hélène Teiten Francois Gaascht Barbora Orlikova Matthias U. Kassack WenHan Lin Marc Diederich
...
Published in
Journal of Medicinal Chemistry
Two new metabolites, embellicines A and B (1 and 2), were isolated from the EtOAc extract of the fungus Embellisia eureka , an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of extensive one- and two-dimensional NMR spectroscopy as well as by high-resolution mass ...
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M. Poplineau C. Doliwa Michael Schnekenburger F. Antonicelli Marc Diederich A. Trussardi-Régnier J. Dufer
Published in
Cell Proliferation
Chromatin texture patterns of tumour cell nuclei can serve as cancer biomarkers, either to define diagnostic classifications or to obtain relevant prognostic information, in a large number of human tumours. Epigenetic mechanisms, mainly DNA methylation and histone post-translational modification, have been shown to influence chromatin packing state...
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Sébastien Chateauvieux Franck Morceau Mario Dicato Marc Diederich
Published in
Journal of Biomedicine and Biotechnology
Valproic acid (VPA), a branched short-chain fatty acid, is widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of Gamma Amino Butyrate (GABA) transaminobutyrate and of ion channels. VPA was recently classified among the Histone Deacetylase Inhibitors, acting directly at the level o...
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Marie-Hélène Teiten Francois Gaascht Mario Dicato Marc Diederich
Published in
Current Pharmaceutical Biotechnology
The aberrant activation of the wingless (Wnt) signaling pathway is a key element involved in carcinogenesis as Wnt regulates a variety of cellular processes including proliferation, differentiation, survival, apoptosis and cell motility. Upon Wnt receptor activation, the canonical “Wnt/beta-catenin” as well as the non canonical “Wnt/planar ce...
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Marie-Hélène Teiten François Gaascht Serge Eifes Mario Dicato Marc Diederich
Published in
Genes & Nutrition
The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention in order to prevent or eradicate prostate malignancies. We present here an overview of the chemopreventive potential of curcumin (diferuloylmethane), a well-known natural compound that exhibits therapeutic promise for prostate c...
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Wamtinga Richard Sawadogo Marc Schumacher Marie-Hélène Teiten Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
Traditional pharmacopeia is strongly involved in the continuous search for the well being of African populations. The World Health Organization (WHO) estimates that 80% of the population of developing countries relies on traditional medicine for their primary care needs. Medicinal plants are the major resource of this folk medicine where several sp...
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Isabelle Buck Franck Morceau Christina Grigorakaki Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
Erythropoiesis is considered as a multistep and tightly regulated process under the control of a series of cytokines including erythropoietin (Epo). Epo activates specific signaling pathways and leads to activation of key transcription factors such as GATA-1, in order to ensure erythroid differentiation. Deregulation leads to a decreased number of ...
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Simone Reuter Michael Schnekenburger Silvia Cristofanon Isabelle Buck Marie-Hélène Teiten Sandrine Daubeuf Serge Eifes Mario Dicato Bharat B. Aggarwal Athanase Visvikis
...
Published in
Biochemical Pharmacology
γ-Glutamyltransferase (GGT) cleaves the γ-glutamyl moiety of glutathione (GSH), an endogenous antioxidant, and is involved in mercapturic acid metabolism and in cancer drug resistance when overexpressed. Moreover, GGT converts leukotriene (LT) C4 into LTD4 implicated in various inflammatory pathologies. So far the effect of inflammatory stimuli o...
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Wamtinga Sawadogo Rainatou Boly Claudia Cerella Marie-Hélène Teiten Mario Dicato Marc Diederich
Published in
Molecules
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Christine Grigorakaki Franck Morceau Sébastien Chateauvieux Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
Many physiological perturbations can cause anemia. In cancer patients, activation of the immune system leads to the production of proinflammatory cytokines including tumor necrosis factor alpha (TNFα), that have been shown to inhibit red-cell production via poorly understood mechanisms. Treatment of anemia by human recombinant erythropoietin (EPO)...
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Mareike Kelkel Marc Schumacher Mario Dicato Marc Diederich
Published in
Free Radical Research
The recent search for new anti-cancer drugs focuses more on natural compounds from the regular human diet because these compounds rarely exhibit severe side-effects yet efficiently act on a wide range of molecular targets involved in carcinogenesis. One promising compound, which is now being tested in clinical studies, is the tomato-derived caroten...
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Elodie Viry Elodie Viry Gilbert Kirsch Claus Jacob Marc Diederich Denyse Bagrel
Published in
International Journal of Oncology
For many years, in vitro and in vivo studies have reported that organosulfur compounds (OSCs), naturally found in Allium vegetables, are able to suppress the proliferation of various tumor cells. In spite of recent advances, the specific molecular mechanisms involved in OSC activity are still unclear. Considering the antiproliferative effects obser...
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Claudia Cerella Mario Dicato Claus Jacob Marc Diederich
Published in
Anti-Cancer Agents in Medicinal Chemistry
Organic sulfur compounds (OSCs) derived from plants, fungi or bacteria can serve as chemopreventive and/or chemotherapeutic agents and have been attracting medical and research interest as a promising source for novel anti-cancer agents. Garlic, which has long been used as a medicinal plant in different cultures due to its multiple beneficial effec...
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Tommy Karius Michael Schnekenburger Jenny Ghelfi Jörn Walter Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
Glutathione-S-transferase P1 (GSTP1) gene is commonly silenced by CpG island promoter hypermethylation in prostate, breast, and liver cancers. However, mechanisms leading to GSTP1 repression by promoter hypermethylation in leukemia and its relationship with pathological alterations of the chromatin structure remain poorly understood. A panel of leu...
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Claudia Cerella Anthoula Gaigneaux Mario Dicato Marc Diederich
Published in
Cancer Letters
Abstract Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector an...
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Marc Diederich
Prostate cancer is the most commun cancer in men in the western world. Lifestyle, diet and environmental as well as genetic factors (e.g. disregulations of the Wingless (Wnt) signaling pathway) promote the malignant transformation of healthy prostatic epithelium. Due to the high prevalence and the slow progressive development of prostate cancer, pr...
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Shéhérazade Hajjouli Sébastien Chateauvieux Marie-Hélène Teiten Barbora Orlikova Marc Schumacher Mario Dicato Chee-Yan Choo Marc Diederich
Published in
Molecules
Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viabili...
