Marc Diederich

Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription

Published in Journal of Neurochemistry

We investigated whether the CYP46A1 gene, a neuronal-specific cytochrome P450, responsible for the majority of brain cholesterol turnover, is subject to transcriptional modulation through modifications in histone acetylation. We demonstrated that inhibition of histone deacetylase activity by trichostatin A (TSA), valproic acid and sodium butyrate c...

Naturally Occurring Regulators of Histone Acetylation/Deacetylation

Published in Current Nutrition & Food Science

Acetylation and deacetylation of lysine residues on histones, which are catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), are epigenetic modifications that play a very important role in the regulation of gene transcription. Perturbation of the balance between histone acetylation and deacetylation leads to a myriad of ...

OMICS, a multidisciplinary friendship.

Published in Cell Death and Disease

A LIM Domain Protein from Tobacco Involved in Actin-Bundling and Histone Gene Transcription

Published in Molecular Plant

The two LIM domain-containing proteins from plants (LIMs) typically exhibit a dual cytoplasmic-nuclear distribution, suggesting that, in addition to their previously described roles in actin cytoskeleton organization, they participate in nuclear processes. Using a south-western blot-based screen aimed at identifying factors that bind to plant histo...

Effect of Curcumin on Nuclear Factor κB Signaling Pathways in Human Chronic Myelogenous K562 Leukemia Cells

Published in Annals of the New York Academy of Sciences

Curcumin, a natural product isolated from the plant Curcuma longa, has a diverse range of molecular targets that influence numerous biochemical and molecular cascades. Curcumin has been shown to inhibit nuclear factor kappaB (NF-kappaB) activation at several steps in the NF-kappaB signaling pathways and thereby controls numerous NF-kappaB-regulated...

Cell cycle arrest in early mitosis and induction of caspase-dependent apoptosis in U937 cells by diallyltetrasulfide (Al...

Published in APOPTOSIS

Naturally occurring organic sulfur compounds (OSCs), such as linear allylsulfides from Allium species, are attracting attention in cancer research, since several OSCs were shown to act beneficially both in chemoprevention and in chemotherapy, while hardly exerting any harmful side effects. Hence, we investigated the possible role of different OSCs ...

Tumor necrosis factor α inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK p...

Published in Biochemical Pharmacology

The proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) has been linked to inflammation- and cancer-related anemia, which reduces both quality of life and prognosis of patients. The aim of this study was to reveal molecular mechanisms linked to the inhibition of erythroid differentiation by TNFalpha. In this study, we showed that the in...

Integrated cellular pathology—Systems biology of human diseases

Published in Biochemical Pharmacology

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Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2

Published in Journal of Pineal Research

We have recently shown that melatonin antagonizes damage-induced apoptosis by interaction with the MT-1/MT-2 plasma membrane receptors. Here, we show that melatonin interferes with the intrinsic pathway of apoptosis at the mitochondrial level. In response to an apoptogenic stimulus, melatonin allows mitochondrial translocation of the pro-apoptotic ...

Targeting the Wingless Signaling Pathway with Natural Compounds as Chemopreventive or Chemotherapeutic Agents

Published in Current Pharmaceutical Biotechnology

The aberrant activation of the wingless (Wnt) signaling pathway is a key element involved in carcinogenesis as Wnt regulates a variety of cellular processes including proliferation, differentiation, survival, apoptosis and cell motility. Upon Wnt receptor activation, the canonical "Wnt/beta-catenin" as well as the non canonical "Wnt/planar cell pol...

Inhibition of TNFα-induced activation of nuclear factor κB by kava (Piper methysticum) derivatives

Published in Biochemical Pharmacology

The inducible transcription factor nuclear factor kappaB (NF-kappaB) plays a central role in the regulation of immune, inflammatory and carcinogenic responses. While normal activation of NF-kappaB is required for cell survival and immunity, its deregulated expression is a characteristic of inflammatory and infectious diseases. In this study, we inv...

Melatonin: A pleiotropic molecule regulating inflammation

Published in Biochemical Pharmacology

Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions. Melatonin also regulates inflammatory and immune processes acting as both an activator and inhibitor of these responses. Melatonin demonstrates endocrine, but also paracrine and autocrine effects in the leukocyte compartment: on one side, leukocyt...

An Introduction to the Molecular Mechanisms of Apoptosis

Published in Annals of the New York Academy of Sciences

Apoptosis is a type of cell death that has been observed and studied for more than a century. The process of apoptosis was described as "programmed cell death" in 1964, and the term apoptosis, from a Greek word meaning "to fall away from" and describing the fall of dead leaves from trees in autumn, was only coined in 1972. During the last 30 years,...

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Published in Cancer Letters

Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter ...

From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment

Published in Biotechnology Advances

Cell death is an important physiological regulator during development, tissue homeostasis and stress response but it is also a protective tumor suppressive mechanism. Tumor cells almost universally acquire the ability to evade cell death pathways that in normal cells act as a protective mechanism to remove damaged cells. As a result, a population o...