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David Rönsberg Abdessamad Debbab Attila Mándi Vera Vasylyeva Philip Böhler Björn Stork Laura Engelke Alexandra Hamacher Richard Sawadogo Marc Diederich
...
Published in
The Journal of Organic Chemistry
Four tetrahydroxanthone dimers (1-4) and four biogenetically related monomers (5-8), including the new derivatives (4-6), were isolated from the endophyte Phomopsis longicolla. The absolute configurations of 2-4 were established for the first time by TDDFT ECD calculations and that of phomoxanthone A (1) was revised by X-ray crystallography. Phomox...
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François Gaascht Mario Dicato Marc Diederich
Published in
Frontiers in Oncology
Chemoprevention uses natural or synthetic molecules without toxic effects to prevent and/or block emergence and development of diseases including cancer. Many of these natural molecules modulate mitogenic signals involved in cell survival, apoptosis, cell cycle regulation, angiogenesis, or on processes involved in the development of metastases occu...
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Jenny Ghelfi Francois Gaascht Claudia Cerella Marie-Hélène Teiten Mario Dicato Marc Diederich Tom Juncker Marc Schumacher Michael Schnekenburger Estelle Henry
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Published in
Biochemical Pharmacology
Cardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to investigate the anti-leukemic activity of UNBS1450, a hemi-synthetic cardenolide belonging to the cardiac steroid glycoside family. Here, we report that, at low nanomolar concentrations, UNBS1450 induces apoptotic cell dea...
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Claudia Cerella Marc Diederich Lina Ghibelli
Published in
International Journal of Cell Biology
Ca(2+) is an important second messenger participating in many cellular activities; when physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor, producing/increasing cell damage. Damage elicits both repair and death responses; intriguingly, in those responses Ca(2+) also participates as second messenger. This d...
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Serge Eifes Claudia Cerella Sébastien Chateauvieux Marc Schumacher Marcel Jaspars Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
In this study, we investigated the biological effects of heteronemin, a marine sesterterpene isolated from the sponge Hyrtios sp. on chronic myelogenous leukemia cells. To gain further insight into the molecular mechanisms triggered by this compound, we initially performed DNA microarray profiling and determined which genes respond to heteronemin s...
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Wamtinga Sawadogo Marc Schumacher Mario Dicato Marc Diederich Claudia Cerella Marie-Hélène Teiten
Published in
Molecules
Cancer continues to be a major public health problem despite the efforts that have been made in the search for novel drugs and treatments. The current sources sought for the discovery of new molecules are plants, animals and minerals. During the past decade, the search for anticancer agents of marine origin to fight chemo-resistance has increased g...
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Marc Diederich
Published in
Cell Cycle
Comment on: Pietrocola, et al. Cell Cycle 2012; 11:3851-60.
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M. Kelkel Claudia Cerella F. Mack T. Schneider C. Jacob M. Schumacher M. Dicato Marc Diederich
Published in
Carcinogenesis
Garlic-derived organosulfur compounds including diallyl polysulfides are well known for various health-beneficial properties and recent reports even point to a potential role of diallyl polysulfides as chemopreventive and therapeutic agents in cancer treatment due to their selective antiproliferative effects. In this respect, diallyl tri- and tetra...
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Silvia Cristofanon Mario Dicato Lina Ghibelli Marc Diederich
Published in
Redox Signaling and Regulation in Biology and Medicine
The decision of a cell to die is triggered by the imbalance between the positive signals,
those needed for continuing to survive (i.e. growth factors), and negative signals
(i.e. DNA damages, increased levels of oxidants) [1]. There are two major mechanisms
of cell death: necrosis and apoptosis. The severity of the injury leads the cells to decide
...
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F. Folmer M. Dicato Marc Diederich
Published in
Current Topics in Medicinal Chemistry
TNF-α was discovered more then 20 years ago as a cytokine implicated in a wide range of cell signaling pathways, many of which are known to lead to the activation of genes involved in inflammation and carcinogenesis. TNF-α is involved in the pathogenesis of many diseases, including Crohn's disease, diabetes, septic shock, tumorigenesis, rheumatoi...
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I. Buck Claudia Cerella S. Cristofanon S. Reuter Marc Diederich
Published in
Biochemical Pharmacology
Almost 40 years have passed from the historical discovery that
cell death in the majority of the cases is not an accidental
event, but corresponds to an extremely conscious and
altruistic, thus highly regulated, process. Since the first
observation in 1972 marked the ‘‘birth’’ of apoptosis, many
advances have been made in the comprehension ...
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A Ivana Scovassi Marc Diederich
Published in
Biochemical Pharmacology
Poly(ADP-ribosylation) is a post-translational modification of proteins playing a crucial role in DNA repair, replication, transcription and cell death. In this paper, the main features of this process have been reviewed, focusing on the best known poly(ADP-ribose) polymerizing enzyme, PARP-1, a DNA nick-sensor protein that uses beta-NAD+ to form p...
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Claudia Cerella Cyril Sobolewski Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
Cyclooxygenase (COX)-2 is a pro-inflammatory immediate early response protein, chronically up-regulated in many pathological conditions. In autoimmune diseases, it is responsible for degenerative effects whereas in cancer, it correlates with poor prognosis. A constitutive expression of COX-2 is triggered since the earliest steps of carcinogenesis. ...
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Michael Schnekenburger Franck Morceau Annelyse Duvoix Sylvie Delhalle Chantal Trentesaux Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
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Cyril Sobolewski Florian Muller Claudia Cerella Mario Dicato Marc Diederich
Published in
Molecular Carcinogenesis
Molecules targeting pro-inflammatory pathways have demonstrated beneficial effects in cancer treatment. More recently, combination of natural and synthetic anti-inflammatory drugs was suggested as an appealing strategy to inhibit tumor growth. Herein, we show that curcumin, a polyphenol from Curcuma longa and celecoxib induce apoptosis in hematopoi...
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Marc Diederich Maria Wellman Athanase Visvikis Alvaro Puga Gérard Siest
Published in
FEBS Letters
We report the functional and structural analysis of the 5' untranslated region (5'UTR) of human hepatoma HepG2 gamma-glutamyltransferase (GGT) mRNA. Transient expression of a hybrid GGT-luciferase gene in HepG2, MIA-Pa-Ca-2 and MG 63 cell lines shows that this 5'UTR acts as a tissue-specific translational enhancer. Evidence for transcripts with mul...
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Florence Folmer Umesh Basavaraju Marcel Jaspars Georgina Hold Emad El-Omar Mario Dicato Marc Diederich
Published in
Phytochemistry Reviews
In the present review, we describe chemical and chemopreventive properties as well as health benefits of both extracts and bioactive compounds from various types of berries including small soft-fleshed edible berries and from berry-like fruits such as strawberries, raspberries, blackberries, blueberries, mulberries, currants, gooseberries, elderber...
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Barbora Orlikova José C.J.M.D.S. Menezes Seungwon Ji Shrivallabh P. Kamat José A.S. Cavaleiro Marc Diederich
Published in
European Journal of Medicinal Chemistry
A new series of chalcones, flavanones and flavones with methylenedioxy group at the 3',4' position in chalcone, 7,8 position in flavanones and flavones with mono-, di- and trimethoxy groups in the benzaldehyde ring have been assessed for their effect on proliferation, cytotoxic potential and apoptosis in human leukemia cells. Among the tested compo...
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Michael Schnekenburger Mario Dicato Seidel Carole Marc Diederich
Published in
Biochimie
Epigenetic alterations are involved in every step of carcinogenesis. The development of chromatin- modifying agents (CMAs) has provided the ability to fight cancer by reversing these alterations. Currently, four CMAs have been approved for cancer treatment; two DNA demethylating agents and two deacetylase inhibitors. A number of promising CMAs are ...
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Mustapha El Amrani Daowan Lai Abdessamad Debbab Amal H. Aly Karsten Siems Carole Seidel Michael Schnekenburger Anthoula Gaigneaux Marc Diederich Daniel Feger
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Published in
Journal of Natural Products
A chemical investigation of the endophytic fungus Epicoccum nigrum isolated from leaves of Mentha suaveolens collected in Morocco resulted in the isolation of five new polyketides, epicocconigrones A and B (1 and 2), 3-methoxyepicoccone B (3), 3-methoxyepicoccone (4), and 2,3,4-trihydroxy-6-(methoxymethyl)-5-methylbenzaldehyde (5), together with fi...
