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Franck Morceau Dupont, C. Palissot, V. Borde-Chiché, Patricia Trentesaux, Chantal Dicato, Mario Marc Diederich
Published in
Leukemia
in Aug 31, 2000
Induction of specific gene expression may provide an alternative or a support to conventional cytotoxic chemotherapy of cancer, as well as to therapy for sickle cell diseases. In this respect, pharmacological induction of expression of the endogenous gamma-globin gene is a realistic approach to therapy of beta-globin disorders. Erythroid differenti...
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Marc Diederich Wellman, Maria Siest, Gérard
Published in
FEBS Letters
in Dec 19, 1994
We are reporting the functional analysis of the 5'-untranslated region (5'UTR) of human hepatoma HepG2 gamma-glutamyltransferase (GGT) mRNA. Transient expression of hybrid GGT-luciferase reporter gene mutants in HepG2 shows that this 5'UTR acts as a tissue-specific translational enhancer. A domain of 173 bases containing a steroid hormone response ...
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Marc Diederich Wellman, Maria Visvikis, Athanase Puga, Alvaro Siest, Gérard
Published in
FEBS Letters
in Oct 11, 1993
We report the functional and structural analysis of the 5' untranslated region (5'UTR) of human hepatoma HepG2 gamma-glutamyltransferase (GGT) mRNA. Transient expression of a hybrid GGT-luciferase gene in HepG2, MIA-Pa-Ca-2 and MG 63 cell lines shows that this 5'UTR acts as a tissue-specific translational enhancer. Evidence for transcripts with mul...
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Courtay, Céline Oster, Thierry Michelet, France Visvikis, Athanase Marc Diederich Wellman, Maria Siest, Gérard
Published in
Biochemical Pharmacology
in Jun 23, 1992
γ-Glutamyltransferase (GGT, EC 2.3.2.2) is an enzyme involved in glutathione metabolism and drug and xenobiotic detoxification. Using human hepatoma Hep G2 GGT cDNA as probe, we isolated a cDNA from a human pancreatic cDNA library. Analysis of the nucleotide sequences revealed a 2244-bp insert that includes an open reading frame of 1710 bp, encodi...
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Weaam Ebrahim Amal H. Aly Victor Wray Attila Mándi Marie-Hélène Teiten Francois Gaascht Barbora Orlikova Matthias U. Kassack WenHan Lin Marc Diederich
...
Published in
Journal of Medicinal Chemistry
Two new metabolites, embellicines A and B (1 and 2), were isolated from the EtOAc extract of the fungus Embellisia eureka , an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of extensive one- and two-dimensional NMR spectroscopy as well as by high-resolution mass ...
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Clemens Zwergel Francois Gaascht Sergio Valente Marc Diederich Denyse Bagrel Gilbert Kirsch
Published in
ChemInform
Aurones [2-benzylidenebenzofuran-3(2H)-ones] are either natural or synthetic compounds, belonging to the flavonoid family. They are isomeric to flavones and provide a bright yellow color to the plants in which they occur. Today, a literature survey indicates that the related flavonoids have been studied not only for their physiological properties a...
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Flavia Radogna Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
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Wamtinga Sawadogo Rainatou Boly Claudia Cerella Marie-Hélène Teiten Mario Dicato Marc Diederich
Published in
Molecules
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Tom Juncker Claudia Cerella Marie-Hélène Teiten Franck Morceau Marc Schumacher Jenny Ghelfi François Gaascht Michael Schnekenburger Estelle Henry Mario Dicato
...
Published in
Biochemical Pharmacology
Cardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to investigate the anti-leukemic activity of UNBS1450, a hemi-synthetic cardenolide belonging to the cardiac steroid glycoside family. Here, we report that, at low nanomolar concentrations, UNBS1450 induces apoptotic cell dea...
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Marc Diederich
In this paper we report the presence and function of the 5' untranslated region (5'UTR) from the mRNA encoding human gamma-glutamyltransferase (GGT) in three different hematopoietic cell lines (HL-60, U-937 and K-562) as well as in the RNA of the leukocyte fraction from six acute lymphoblastic leukemias (ALL). Results obtained by RNase protection a...
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Marc Diederich
Prostate cancer is the most commun cancer in men in the western world. Lifestyle, diet and environmental as well as genetic factors (e.g. disregulations of the Wingless (Wnt) signaling pathway) promote the malignant transformation of healthy prostatic epithelium. Due to the high prevalence and the slow progressive development of prostate cancer, pr...
