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Michael Schnekenburger Eric Goffin Jin-Young Lee Jun Young Jang Aloran Mazumder Seungwon Ji Bernard Rogister Nafila Bouider Florence Lefranc Walter Miklos
...
Published in
Journal of Medicinal Chemistry
in May 08, 2017
A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. Based on computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyano...
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Marc Diederich Claudia Cerella
Published in
Seminars in Cancer Biology
in May 31, 2016
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Claudia Cerella Cindy Grandjenette Mario Dicato Marc Diederich
Published in
Current Drug Targets
in Feb 16, 2016
Cancer and aging are two similar processes representing the final outcome of time-dependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damage that are altered in both cancer and aging, albeit through different mechanisms....
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Seidel Carole Michael Schnekenburger Aloran Mazunder Marie-Hélène Teiten Gilbert Kirsch Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
in Jan 02, 2016
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including a-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
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Wamtinga Sawadogo Ali Al-Mourabit Céline Moriou Innocent Guissou Mario Dicato Marie-Hélène Teiten Marc Diederich
Published in
Nutrients
in Dec 25, 2015
Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. ...
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Festus B.C. Okoye Wamtinga Richard Sawadogo Jandirk Sendker Amal H. Aly Bettina Quandt Victor Wray Andreas Hensel Charles O. Esimone Abdessamad Debbab Marc Diederich
...
Published in
Journal of Ethnopharmacology
in Dec 18, 2015
Ethnopharmacological relevance: Olax mannii Oliv. (Olacaceae) is among the many medicinal plants used in Nigeria for the ethnomedicinal management of both cancer and inflammation. Such plants represent potential sources of innovative therapeutic agents for the treatment of cancer and other malignant disorders. While the majority of medicinal plants...
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C. Sobolewski J. Rhim N. Legrand F. Muller C. Cerella F. Mack S. Chateauvieux J.-G. Kim A.-Y. Yoon K.-W. Kim
...
Published in
Journal of Pharmacology and Experimental Therapeutics
in Aug 31, 2015
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Claudia Cerella Florian Muller Anthoula Gaigneaux Flavia Radogna Elodie Viry Sébastien Chateauvieux Mario Dicato Marc Diederich
Published in
Cell Death and Disease
in Jun 07, 2015
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na + /K +)-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis ...
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Cindy Grandjenette Michael Schnekenburger Franck Morceau Fabienne Mack Katja Wiechmann Oliver Werz Mario Dicato Marc Diederich
Published in
Anti-Cancer Agents in Medicinal Chemistry
in Jan 11, 2015
Despite recent advances in the treatment of chronic myelogenous leukemia (CML), the development of drug resistance and minimal residual disease remain major challenges for the treatment of CML patients, thus highlighting the need to develop innovative new approaches to improve therapeutic outcome. Myrtucommulone A (MCA) is a nonprenylated acylphlor...
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Franck Morceau Sébastien Chateauvieux Anthoula Gaigneaux Mario Dicato Marc Diederich
Published in
International Journal of Molecular Sciences
in Jul 10, 2013
Genomic analyses estimated that the proportion of the genome encoding proteins corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that many non-coding DNA-regions generate non-coding RNAs (ncRNAs). The relevance of these ncRNAs in biological, physiological as well as in pathological processes increased over the last t...
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Daniel J Klionsky Marc Diederich
Published in
Autophagy
in Apr 17, 2012
Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for 2100 reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines
are not meant to be a formulaic s...
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Marie-Hélène Teiten Francois Gaascht Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
Since centuries, natural compounds from plants, animals and microorganisms were used in medicinal traditions to treat various diseases without a solid scientific basis. Recent studies have shown that plants that were used or are still used in the medieval European medicine are able to provide relieve for many diseases including cancer. Here we summ...
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Clemens Zwergel Francois Gaascht Sergio Valente Marc Diederich Denyse Bagrel Gilbert Kirsch
Published in
ChemInform
Aurones [2-benzylidenebenzofuran-3(2H)-ones] are either natural or synthetic compounds, belonging to the flavonoid family. They are isomeric to flavones and provide a bright yellow color to the plants in which they occur. Today, a literature survey indicates that the related flavonoids have been studied not only for their physiological properties a...
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Simone Reuter Serge Eifes Mario Dicato Bharat B. Aggarwal Marc Diederich
Published in
Biochemical Pharmacology
Apoptosis is a highly regulated mechanism by which cells undergo cell death in an active way. As one of the most challenging tasks concerning cancer is to induce apoptosis in malignant cells, researchers increasingly focus on natural products to modulate apoptotic signaling pathways. Curcumin, a natural compound isolated from the plant Curcuma long...
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Flavia Radogna Claudia Cerella Anthoula Gaigneaux C Christov M DICATO Marc Diederich
Published in
Oncogene
A limiting factor in the therapeutic outcome of children with high-risk neuroblastoma is the intrinsic and acquired resistance to common chemotherapeutic treatments. Here we investigated the molecular mechanisms by which the hemisynthetic cardiac glycoside UNBS1450 overcomes this limitation and induces differential cell death modalities in both neu...
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Romain Blasius Annelyse Duvoix Franck Morceau Michael Schnekenburger Sylvie Delhalle Estelle Henry Mario Dicato Marc Diederich
Published in
Annals of the New York Academy of Sciences
To investigate the stability of curcumin in physiological media, the absorption variation of a curcumin solution was measured in 0.1% and 10% FCS. Under daylight conditions, curcumin degraded very rapidly in 0.1% FCS and was found to be more stable in higher serum concentrations. Under dark conditions, almost no decomposition could be observed afte...
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Franck Morceau Annelyse Duvoix Sylvie Delhalle Michael Schnekenburger Mario Dicato Marc Diederich
Published in
Biochemical Pharmacology
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Patricia Borde-Chiché Franck Morceau Maria Wellman Mario Dicato Marc Diederich
Published in
Leukemia Research
Overexpression of the glutathione S-transferase P1 (GSTP1) gene is related to drug resistance in human cancer cells. However, the mechanisms of the transcriptional activation of this gene remain unclear. In this study, we examined the molecular mechanisms underlying phorbol ester mediated gene regulation using human K562 leukemia cells as a model. ...
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Franck Morceau Marc Diederich
Published in
Biotechnology Advances
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Barbora Orlikova Mario Dicato Marc Diederich
Published in
Phytochemistry Reviews
Over the past decades, apoptosis emerged as a leading strategy to eliminate cancer cells. Nowadays, it becomes progressively clear that apoptosis is not the only programmed cell death mechanism implicated in the elimination of malignant cells. This review will discuss non-apoptotic cell death modalities and will focus on natural compounds acting as...
