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Hélène Losson Gajulapalli, Sruthi Reddy Manon Lernoux Lee, Jin-Young Mazumder, Aloran Gérard, Déborah Seidel Carole Hahn, Hyunggu Christov, Christo Dicato, Mario
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Pharmacological Research
Despite the discovery of tyrosine kinase inhibitors (TKIs) for the treatment of breakpoint cluster region-Abelson (BCR-ABL) + cancer types, patients with chronic myeloid leukemia (CML) treated with TKIs develop resistance and severe adverse effects. Combination treatment, especially with a histone deacetylase (HDAC) 6 inhibitor (HDAC6i), appears to...
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Manon Lernoux Michael Schnekenburger Hélène Losson Vermeulen, Koen Hahn, Hyunggu Gérard, Déborah Lee, Jin-Young Mazumder, Aloran Ahamed, Muneer Christov, Christo
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Published in
Clinical Epigenetics
Background: Chronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnormal constitutive tyrosine kinase activity, therapies using tyrosine kinase inhibitors (TKis) such as imatinib represent a major bre...
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Sébastien Chateauvieux Gaigneaux, Anthoula Gérard, Déborah Marion Orsini Franck Morceau Barbora Orlikova Farge, Thomas Récher, Christian Sarry, Jean-Emmanuel Dicato, Mario
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Published in
Haematologica
No abstract available
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Marion Orsini Sébastien Chateauvieux Rhim, Jiyun Gaigneaux, Anthoula Cheillan, David Christov, Christo Dicato, Mario Franck Morceau Marc Diederich
Published in
Cell Death and Differentiation
Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptos...
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Flavia Radogna Marc Diederich
Published in
Biochemical Pharmacology
Cancer is evading the host's defense mechanisms leading to avoidance of immune destruction. During tumor progression, immune-evading cancer cells arise due to selective pressure from the hypoxic and nutrient-deprived microenvironment. Thus, therapies aiming at re-establishing immune destruction of pathological cells constitute innovating anti-cance...
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Esma Yagdi Mazumder, Aloran Lee, Jin-Young Anthoula Gaigneaux Flavia Radogna Nasim, Muhammad Jawad Christov, Christo Jacob, Claus Kim, Kyu-Won Dicato, Mario
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Published in
Cancer Letters
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
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Michael Schnekenburger Goffin, Eric Lee, Jin-Young Young Jang, Jun Mazumder, Aloran Ji, Seungwon Rogister, Bernard Bouider, Nafila Lefranc, Florence Miklos, Walter
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Published in
Journal of Medicinal Chemistry
A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. Based on computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyano...
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Marc Diederich Florian Muller Claudia Cerella
Published in
Biochemical Pharmacology
Cardiac glycosides (CGs) are approved for the treatment of cardiovascular alterations and their known cellular target is the alpha subunit of the sodium (Na+)/potassium (K+)-ATPase (NKA). Pharmacologically, they represent a well-known generation of drugs for treating cardiovascular problems, thus allowing the investigation of potential dose-depende...
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Zovko Končić, Marijana Ioannou, Efstathia Sawadogo, Wamtinga Richard Abdel-razik, Ayman F. Vagias, Constantinos Marc Diederich Roussis, Vassilios
Published in
Steroids
Seven new (1–3, 5 and 8–10) and three previously reported (4, 6 and 7) 4α-methylated steroids were isolated from the organic extract of the gorgonian Litophyton mollis. The structures and the relative configurations of the isolated natural products were determined on the basis of extensive analyses of their NMR and MS data. Metabolites 1 and 5–8 ex...
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Hélène Losson Michael Schnekenburger Dicato, Mario Marc Diederich
Published in
Molecules
The remarkable complexity of cancer involving multiple mechanisms of action and specific organs led researchers Hanahan and Weinberg to distinguish biological capabilities acquired by cancer cells during the multistep development of human tumors to simplify its understanding. These characteristic hallmarks include the abilities to sustain prolifera...
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Claudia Cerella Gaigneaux, A Mazumder, A Lee, J-y Saland, E Flavia Radogna Farge, T Vergez, F Récher, C Sarry, J-e
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Published in
Leukemia
Leukemia accepted article preview online, 22 November 2016. doi:10.1038/leu.2016.341
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Marc Diederich Claudia Cerella
Published in
Seminars in Cancer Biology
Natural compounds are the fundament of pharmacological treatments and more than 50% of all anticancer drugs are of natural origins or at least derived from scaffolds present in Nature. Over the last 25 years, molecular mechanisms triggered by natural anticancer compounds were investigated. Emerging research showed that molecules of natural origins ...
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Perczel, András Atanas Atanasov Sklenář, Vladimír Nováček, Jiří Papoušková, Veronika Kadeřávek, Pavel Žídek, Lukáš Kozłowski, Henryk Wątły, Joanna Hecel, Aleksandra
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Published in
Molecules
The Eighth Central European Conference “Chemistry towards Biology” was held in Brno, Czech Republic, on 28 August–1 September 2016 to bring together experts in biology, chemistry and design of bioactive compounds; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. Th...
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Esma Yagdi Claudia Cerella Dicato, Mario Marc Diederich
Published in
Food and Chemical Toxicology
In vitro and in vivo studies reported the anti-cancer potential of organosulfur compounds (OSCs) as they trigger biological effects leading to cell cycle arrest with accumulation of cells in G2/M, alteration of the microtubular network, modulation of Bcl-2 family protein expression patterns and changes of the redox status. Despite these well-descri...
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Cristina Florean Michael Schnekenburger Jin-Young Lee Kyung Kim Aloran Mazumder Sungmi Song Jae-Myun Kim Cindy Grandjenette Jeoung-Gyun Kim Ah-Young Yoon
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Published in
Oncotarget
We characterized the brominated alkaloid Isofistularin-3 (Iso-3), from the marine sponge Aplysina aerophoba, as a new DNA methyltransferase (DNMT)1 inhibitor. Docking analysis confirmed our in vitro DNMT inhibition data and revealed binding of Iso-3 within the DNA binding site of DNMT1. Subsequent increased expression of tumor suppressor gene aryl ...
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Claudia Cerella Cindy Grandjenette Dicato, Mario Marc Diederich
Published in
Current Topics in Medicinal Chemistry
Cancer and aging are two similar processes representing the final outcome of time-dependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damage that are altered in both cancer and aging, albeit through different mechanisms....
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Seidel, Carole Marc Diederich Mazumder, Aloran Kirsch, Gilbert Dicato, Mario Michael Schnekenburger Marie-Hélène Teiten
Published in
Biochemical Pharmacology
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including α-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
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Marc Diederich Guissou, I Noufou, Ouédraogo Sawadogo, W Tibiri, A Lompo, M Dijoux, M
Published in
British Journal of Pharmaceutical Research
Aim: To investigate the cytotoxic effect of methanol extract of Ptreocarpus erinaceus stem barks against cancer lines (Leukemia cell K562 and lung small cells A549) and its inhibition effects against NF-kB activation and lipoxygenase enzyme. Moreover, phenolic compounds, tannins and flavonoids amounts have been determined. Study Design: In vitro ev...
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B.C. Okoye, Festus Richard Sawadogo, Wamtinga Sendker, Jandirk Aly, Amal H. Quandt, Bettina Wray, Victor Hensel, Andreas Esimone, Charles O. Debbab, Abdessamad Marc Diederich
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Published in
Journal of Ethnopharmacology
Ethnopharmacological relevance: Olax mannii Oliv. (Olacaceae) is among the many medicinal plants used in Nigeria for the ethnomedicinal management of both cancer and inflammation. Such plants represent potential sources of innovative therapeutic agents for the treatment of cancer and other malignant disorders. While the majority of medicinal plants...
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Sawadogo, Wamtinga Al-Mourabit, Ali Moriou, Céline Guissou, Innocent Dicato, Mario Marie-Hélène Teiten Marc Diederich
Published in
Nutrients
Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. ...
