Publications - Malik Bisserier - Page 1

Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmona...

Strauss, Benjamin Sassi, Yassine Bueno-Beti, Carlos Ilkan, Zeki Raad, Nour Cacheux, Marine Malik Bisserier Turnbull, Irene C. Kohlbrenner, Erik Hajjar, Roger J. ...

Published in Journal of Molecular and Cellular Cardiology

Background Pulmonary arterial hypertension (PAH) results in right ventricular (RV) failure, electro-mechanical dysfunction and heightened risk of sudden cardiac death (SCD), although exact mechanisms and predisposing factors remain unclear. Because impaired chronotropic response to exercise is a strong predictor of early mortality in patients with...

Mechanisms of resistance to EZH2 inhibitors in diffuse large B-cell lymphomas

Malik Bisserier Wajapeyee, Narendra

Published in Blood

Resistance to targeted therapies has become increasingly prevalent. We noted that resistance to different targeted therapies occurs by largely common mechanisms. In this study, we used this information for identifying the mechanisms of resistance to enhancer of zeste homolog 2 (EZH2) inhibitors in diffuse large B-cell lymphoma (DLBCL) harboring EZH...

Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.

Fazal, Loubina Laudette, Marion Paula-Gomes, Sílvia Pons, Sandrine Conte, Caroline Tortosa, Florence Sicard, Pierre Sainte-Marie, Yannis Malik Bisserier Lairez, Olivier ...

Published in Circulation Research

Although the second messenger cyclic AMP (cAMP) is physiologically beneficial in the heart, it largely contributes to cardiac disease progression when dysregulated. Current evidence suggests that cAMP is produced within mitochondria. However, mitochondrial cAMP signaling and its involvement in cardiac pathophysiology are far from being understood.

Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

Gupta, Romi Forloni, Matteo Malik Bisserier Dogra, Shaillay Kumar Yang, Qiaohong Wajapeyee, Narendra

Published in eLife

Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replication stress due to dysregulated DNA replication via...

Les acteurs moléculaires du remodelage cardiaque pathologique

Sainte-Marie, Yannis Malik Bisserier Tortosa, Florence Lezoualc’h, Frank

Published in médecine/sciences

L’exercice physique ou l’hypertension artérielle sont deux situations, l’une physiologique, l’autre pathologique, au cours desquelles le cœur augmente son travail hémodynamique. Cette adaptation repose sur un remodelage cardiaque différent selon la nature physiologique ou pathologique du stress. Illustrée par deux exemples, l’étude des événements m...

Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.

Laurent, Anne-Coline Malik Bisserier Lucas, Alexandre Tortosa, Florence Roumieux, Marie De Régibus, Annélie Swiader, Audrey Sainte-Marie, Yannis Heymes, Christophe Vindis, Cécile ...

Published in Cardiovascular Research

Altogether, these findings demonstrate that autophagy is an adaptive response to antagonize Epac1-promoted cardiomyocyte hypertrophy.

Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras, and Ca 2+ /Calmodulin-D...

Malik Bisserier Berthouze-Duquesnes, Magali Breckler, Magali Tortosa, Florence Fazal, Loubina de Régibus, Annélie Laurent, Anne-Coline Varin, Audrey Lucas, Alexandre Branchereau, Maxime ...

Published in Circulation

Background— Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and is regulated by various signaling pathways. However, the molecular mechanisms that negatively regulate these signal transduction pathways remain poorly understood. Methods and Results— Here, we characterized Carabin, a protein expressed in card...