Malik Bisserier

Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hyper...

Pulmonary arterial hypertension (PAH) is a devastating lung disease characterized by the progressive obstruction of the distal pulmonary arteries (PA). Structural and functional alteration of pulmonary artery smooth muscle cells (PASMC) and endothelial cells (PAEC) contributes to PA wall remodeling and vascular resistance, which may lead to maladap...

Mechanisms of resistance to EZH2 inhibitors in diffuse large B-cell lymphomas

Published in Blood

Resistance to targeted therapies has become increasingly prevalent. We noted that resistance to different targeted therapies occurs by largely common mechanisms. In this study, we used this information for identifying the mechanisms of resistance to enhancer of zeste homolog 2 (EZH2) inhibitors in diffuse large B-cell lymphoma (DLBCL) harboring EZH...

Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.

Published in Circulation Research

Although the second messenger cyclic AMP (cAMP) is physiologically beneficial in the heart, it largely contributes to cardiac disease progression when dysregulated. Current evidence suggests that cAMP is produced within mitochondria. However, mitochondrial cAMP signaling and its involvement in cardiac pathophysiology are far from being understood.

Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

Published in eLife

Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replication stress due to dysregulated DNA replication via...

Les acteurs moléculaires du remodelage cardiaque pathologique

Published in médecine/sciences

L’exercice physique ou l’hypertension artérielle sont deux situations, l’une physiologique, l’autre pathologique, au cours desquelles le cœur augmente son travail hémodynamique. Cette adaptation repose sur un remodelage cardiaque différent selon la nature physiologique ou pathologique du stress. Illustrée par deux exemples, l’étude des événements m...

Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.

Published in Cardiovascular Research

Altogether, these findings demonstrate that autophagy is an adaptive response to antagonize Epac1-promoted cardiomyocyte hypertrophy.

Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras, and Ca 2+ /Calmodulin-D...

Published in Circulation

Background— Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and is regulated by various signaling pathways. However, the molecular mechanisms that negatively regulate these signal transduction pathways remain poorly understood. Methods and Results— Here, we characterized Carabin, a protein expressed in card...