Lan Yu

Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells

Published in Journal of Investigative Dermatology Symposium Proceedings

Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis

Published in American Journal Of Pathology

Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation

Published in Journal of Investigative Dermatology Symposium Proceedings

Role of galectin-3 in mast cell functions. Galectin-3-deficient mast cells exhibit impaired mediator release and defecti...

Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology

Galectin-12 is Required for Adipogenic Signaling and Adipocyte Differentiation

Published in JBIC Journal of Biological Inorganic Chemistry

Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma

Published in American Journal Of Pathology

Critical role of galectin-3 in phagocytosis by macrophages

Published in Journal of Investigational Allergology and Clinical Immunology

IgE-dependent mast cell activation potentiates airway responses in murine asthma models

Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology

Cell cycle regulation by galectin-12, a new member of the galectin superfamily

Published in JBIC Journal of Biological Inorganic Chemistry

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology

Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses

Published in American Journal Of Pathology

Melanocytic galectin-3 is associated with tyrosinase-related protein-1 and pigment biosynthesis.

Published in Journal of Investigative Dermatology

Galectin-3 is a family member of the carbohydrate-binding proteins widely expressed by many cell types and exhibits multiple cellular functions. We demonstrate that melanocytes express galectin-3, which is predominantly localized to the cell body peripherally along the Golgi zone. Downregulation of galectin-3 in human melanocytes using short hairpi...

Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insul...

Published in Proceedings of the National Academy of Sciences

The breakdown of triglycerides, or lipolysis, is a tightly controlled process that regulates fat mobilization in accord with an animal s energy needs. It is well established that lipolysis is stimulated by hormones that signal energy demand and is suppressed by the antilipolytic hormone insulin. However, much still remains to be learned about regul...

Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis....

Galectin-12, a member of the galectin family of β-galactoside-binding animal lectins, is preferentially expressed in adipocytes and required for adipocyte differentiation in vitro. This protein was recently found to regulate lipolysis, whole body adiposity, and glucose homeostasis in vivo. Here we identify VPS13C, a member of the VPS13 family of va...