Anti-Human type II collagen CD19+ B cells are present in patients with rheumatoid arthritis and healthy individuals.
Published in The Journal of Rheumatology
Type II collagen-induced arthritis.
Published in Annals of the New York Academy of Sciences
HALO384: a halo-based potency prediction algorithm for high-throughput detection of antimicrobial agents.
Published in Journal of Biomolecular Screening
A high-throughput (HT) agar-based halo assay is described, which allows for rapid screening of chemical libraries for bioactivity in microorganisms such as yeast and bacteria. A pattern recognition algorithm was developed to identify halo-like shapes in plate reader optical density (OD) measurements. The authors find that the total growth inhibitio...
The Cancer Genome Atlas Pan-Cancer analysis project.
Published in Nature Genetics
The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pa...
Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheuma...
Published in Arthritis & Rheumatism
Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I-radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fl...
An outbreak of meningococcal disease in Stonehouse: planning and execution of a large-scale survey.
Published in Epidemiology and Infection
In November 1986 a large-scale survey was undertaken in the Gloucestershire town of Stonehouse during an outbreak of meningococcal disease due to group B type 15 subtype P1.16 sulphonamide-resistant strains. There were 15 cases in Stonehouse residents during the 4 years from April 1983, an annual attack rate of 56.5 per 100,000. Four secondary case...
Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice.
Published in Agents and Actions
The type II collagen induced arthritis model was used to evaluate the efficacy of tissue inhibitor of metalloproteases (TIMP) in suppressing the disease in DBA/1 mice. Treatment began following the first clinical manifestations of the disease state. Clinical observations, histological and radiographic findings show a decreased incidence of joint er...
Cryptosporidium outbreak linked to interactive water feature, UK: importance of guidelines.
Published in Eurosurveillance
A need for national guidelines relating to interactive water features was highlighted following three outbreaks of cryptosporidiosis in the United Kingdom, all of which were related to public water features. In August 2003 the Health Protection Agency South West of England was notified of an outbreak of cryptosporidiosis associated with an interact...
Assessment of medical technology students perceptions of clinical site rotations and job choice criteria.
Published in Clinical leadership & management review : the journal of CLMA
This study reflects an assessment conducted at the University of Utah to determine medical laboratory science students perceptions and influence of clinical rotations on job choice criteria. A mixed method design was used, incorporating semistructured interviews and mailed questionnaires. This study identified both favorable as well as unfavorable...
Pustular blastomycosis.
Published in Current Topics in Medicinal Chemistry
A 53-year-old Negro man had North American blastomycosis with acute onset of widespread pustular eruptions. Several tests suggested that the patient might have had a deficiency of delayed hypersensitivity.
T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage....
Published in Arthritis & Rheumatism
Recommending pathway genes using a compendium of clustering solutions.
Published in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
A common approach for identifying pathways from gene expression data is to cluster the genes without using prior information about a pathway, which often identifies only the dominant coexpression groups. Recommender systems are well-suited for using the known genes of a pathway to identify the appropriate experiments for predicting new members. How...
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin.
Published in Cell
Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a u...
