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Josh Stuart Ae, Postlethwaite As, Townes Ah, Kang
Published in
The American Journal of Medicine
Peripheral blood mononuclear cells from patients with rheumatoid arthritis, gout, ankylosing spondylitis and degenerative joint disease were cultured in the presence of native types I, II and III collagens and alpha chains from each of these types of collagen. The culture supernatant fluids were harvested and assayed for lymphocyte-derived chemotat...
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Josh Stuart Jj, Paris C, Frye Hb, Bradshaw
Published in
International Journal of Endocrinology
Background. Endogenous cannabinoids (eCBs) are involved in the development and regulation of reproductive behaviors. Likewise, prostaglandins (PGs) drive sexual differentiation and initiation of ovulation. Here, we use lipidomics strategies to test the hypotheses that mating immediately activates the biosynthesis and/or metabolism of eCBs and PGs a...
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H, Miyahara Lk, Myers Ef, Rosloniec Dd, Brand Jm, Seyer Josh Stuart Ah, Kang
Published in
Immunology
Tolerization of B10.RIII mice (H-2r) with intravenously injected type II collagen (CII) renders the animals resistant to induction of collagen-induced arthritis (CIA). In order to clarify H-2r-restricted T-cell responses that modulate CIA, we have analysed the T-cell proliferative response of B10.RIII mice against cyanogen bromide (CB) peptides of ...
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Ae, Cozen Mt, Weirauch Ks, Pollard Dl, Bernick Josh Stuart Tm, Lowe
Published in
Journal of Bacteriology
Hyperthermophilic crenarchaea in the genus Pyrobaculum are notable for respiratory versatility, but relatively little is known about the genetics or regulation of crenarchaeal respiratory pathways. We measured global gene expression in Pyrobaculum aerophilum cultured with oxygen, nitrate, arsenate and ferric iron as terminal electron acceptors to i...
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Rs, Heyderman Hp, Lambert I, O Sullivan Josh Stuart Bl, Taylor Ra, Wall
Published in
Journal of Infection
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Lk, Myers B, Tang Dd, Brand Ef, Rosloniec Josh Stuart Ah, Kang
Published in
Arthritis & Rheumatism
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Josh Stuart Wc, Watson Ah, Kang
Published in
The FASEB Journal
Collagen-induced arthritis in animals is an example of polyarthritis that sufficiently resembles human rheumatoid arthritis to be used as a model. It is caused by immunizing susceptible animals with type II collagen isolated from articular cartilage. Susceptibility is genetically determined and linked to the major histocompatibility locus. It is im...
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E, Van De Venter I, Oliver Josh Stuart
Published in
Eurosurveillance
Timely outbreak investigations are central in containing communicable disease outbreaks; despite this, no guidance currently exists on expectations of timeliness for investigations. A literature review was conducted to assess the length of epidemiological outbreak investigations in Europe in peer-reviewed publications. We determined time intervals ...
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W, Wei Y, Jiao A, Postlethwaite Josh Stuart Y, Wang D, Sun W, Gu
Published in
Genes and Immunity
Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential ro...
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Pc, Boutros Ad, Ewing K, Ellrott Tc, Norman Kk, Dang Y, Hu Mr, Kellen C, Suver Jc, Bare Ld, Stein
...
Published in
Nature Genetics
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Lk, Myers B, Tang Ef, Rosioniec Josh Stuart Ah, Kang
Published in
Critical Reviews in Immunology
On the basis of the hypothesis that immunity to type II collagen (CII) contributes to joint inflammation, our goal is to develop an immunotherapy capable of selectively blocking immunity to a particular autoantigen without interfering with the beneficial functions of the immune system. CII is the major protein component of articular cartilage and a...
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Eo, Paull De, Carlin M, Niepel Pk, Sorger David Haussler Josh Stuart
Published in
Bioinformatics
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Dg, Spinella Jr, Jeffers Ra, Reife Josh Stuart
Published in
Immunogenetics
Collagen-induced arthritis (CIA) is a rodent arthritis model in which immunization with heterologous type II collagen induces an inflammatory polyarthritis. Susceptibility to the disease is mediated by major histocompatibility complex (MHC) genes as well as genes at other loci. Previous studies of the SWR/J mouse strain, which is resistant to CIA d...
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Mc, Levin Sm, Lee F, Kalume Y, Morcos Jr, Dohan Fc Ka, Hasty Jc, Callaway J, Zunt D, Desiderio Josh Stuart
...
Published in
Nature Medicine
One hypothesis that couples infection with autoimmune disease is molecular mimicry. Molecular mimicry is characterized by an immune response to an environmental agent that cross-reacts with a host antigen, resulting in disease. This hypothesis has been implicated in the pathogenesis of diabetes, lupus and multiple sclerosis (MS). There is limited d...
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Josh Stuart As, Townes Ah, Kang
Published in
Annals of the New York Academy of Sciences
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Josh Stuart Ma, Cremer Sn, Dixit Ah, Kang As, Townes
Published in
Arthritis & Rheumatism
An oil emulsion of purified type II collagen from bovine articular cartilage when injected intradermally into rats induced an inflammatory polyarthritis in 4 of 12 animals. When similarly injected, collagen purified from bonve vitreous induced arthritis in 6 of 12 animals. Studies of humoral and cell-mediated immunity to both collagen preparations ...
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Juhee Lee Jw, Phillips Ba, Smith Jw, Park T, Stoyanova Ef, Mccaffrey R, Baertsch A, Sokolov Jg, Meyerowitz C, Mathis
...
Published in
Cancer Cell
MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated AKT1 as oncogenic components sufficient to transform human prostate epithelial cells to prostat...
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B, Tang S, Kim S, Hammond Dl, Cullins Dd, Brand Ef, Rosloniec Josh Stuart Ae, Postlethwaite Ah, Kang Lk, Myers
...
Published in
Arthritis Research & Therapy
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Kl, Davison N, Andrews Jm, White Me, Ramsay Ns, Crowcroft Aa, Rushdy Eb, Kaczmarski Pn, Monk Josh Stuart
Published in
Archives of Disease in Childhood
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Lk, Myers Josh Stuart Ah, Kang
Published in
The Journal of Immunology
Collagen-induced arthritis can be suppressed by i.v. injection of intact type II collagen (CII) but not type I collagen before immunization. To identify the mechanism mediating this suppression, splenocytes were obtained from mice injected with CII or OVA and administered to recipients that were subsequently immunized with CII. Mice receiving cells...
