Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways
Published in International Journal of Molecular Sciences
Published in International Journal of Molecular Sciences
Published in Methods
Published in Nature Communications
Published in Biologie Aujourd hui
Published in Cilia
Published in Journal of Molecular and Genetic Medicine
Published in International Journal of Molecular Sciences
The yeast Saccharomyces cerevisiae is one of the best characterized eukaryotic models. The secretory pathway was the first trafficking pathway clearly understood mainly thanks to the work done in the laboratory of Randy Schekman in the 1980s. They have isolated yeast sec mutants unable to secrete an extracellular enzyme and these SEC genes were ide...
Published in Journal of Cell Science
Published in PLoS ONE
The formation and budding of endoplasmic reticulum ER-derived vesicles depends on the COPII coat protein complex that was first identified in yeast Saccharomyces cerevisiae. The ER-associated Sec12 and the Sar1 GTPase initiate the COPII coat formation by recruiting the Sec23-Sec24 heterodimer following the subsequent recruitment of the Sec13-Sec31 ...
Published in PLoS ONE
Published in BMC Genomics
Published in Molecular Biology of the Cell
Published in The Journal of Cell Biology
Published in Journal of Biological Chemistry
Published in Journal of Biological Chemistry
Membrane trafficking of the general amino acid per-mease (Gap1) of Saccharomyces cerevisiae is under nitrogen regulation. In cells growing on proline or urea as the sole nitrogen source, newly synthesized Gap1 is delivered to the plasma membrane, where it accumulates. Upon addition of NH 4 , a preferential nitrogen source, Gap1 is endocytosed and t...
Published in Molecular and Cellular Biology
The SSY1 gene of Saccharomyces cerevisiae encodes a member of a large family of amino acid permeases. Compared to the 17 other proteins of this family, however, Ssy1p displays unusual structural features reminiscent of those distinguishing the Snf3p and Rgt2p glucose sensors from the other proteins of the sugar transporter family. We show here that...
Published in Molecular and Cellular Biology
Published in Biochemical and Biophysical Research Communications