Publications - Jinfeng Shen - Page 1

APR-246/PRIMA-1MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 m...

Jinfeng Shen van den Bogaard, E. H. Kouwenhoven, E. N. Bykov, V. J. N. Rinne, T. Zhang, Q. Tjabringa, G. S. Gilissen, C. van Heeringen, S. J. Schalkwijk, J. ...

Published in Proceedings of the National Academy of Sciences

p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) sy...

PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2

Jinfeng Shen H Vakifahmetoglu H Stridh B Zhivotovsky K G Wiman

Published in Oncogene

p53 mutations occur frequently in human tumors. The low-molecular-weight compound PRIMA-1 MET reactivates mutant p53, induces apoptosis in human tumor cells and inhibits tumor xenograft growth in vivo. Here, we show that PRIMA-1 MET induces mutant p53-dependent mito-chondria-mediated apoptosis through activation of caspase-2 with subsequent cytochr...