Jill Meisenhelder

Regulation of the cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex

Published in Plant and Cell Physiology

An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway

Published in Genes & Development

Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene w...

Published in Acta Biochimica et Biophysica Sinica

Identification of TrkB autophosphorylation sites and evidence that phospholipase C-g1 is a substrate of the TrkB recepto...

Published in JBIC Journal of Biological Inorganic Chemistry

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-g1 monoclonal antibodies and its...

Published in American Journal of Molecular and Cellular Biology

Methods for studying the phosphorylation of phospholipase C in vivo and in vitro

Published in Methods in Enzymology

Protein-tyrosine kinases and their substrates: old friends and new faces

Phospholipase C-g is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Published in Cell

Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors

Published in American Journal of Molecular and Cellular Biology

A431 cell variants lacking the blood group A antigen display increased high affinity epidermal growth factor receptor nu...

Published in American Journal of Molecular and Cellular Biology

Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related...

Published in The EMBO Journal

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine...

Published in JBIC Journal of Biological Inorganic Chemistry

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading.

Published in The Journal of Cell Biology

Filopodia are dynamic F-actin structures that cells use to explore their environment. c-Abl tyrosine kinase promotes filopodia during cell spreading through an unknown mechanism that does not require Cdc42 activity. Using an unbiased approach, we identified Dok1 as a specific c-Abl substrate in spreading fibroblasts. When activated by cell adhesion...

Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1.

Published in Developmental Cell

The leucine-rich-repeat receptor serine/threonine kinase, BRI1, is a cell-surface receptor for brassinosteroids (BRs), the steroid hormones of plants, yet its activation mechanism is unknown. Here, we report a unique autoregulatory mechanism of BRI1 activation. Removal of BRI1 s C terminus leads to a hypersensitive receptor, indicated by suppressio...

Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark target...

Published in Molecular Cell

Viral hijacking of cellular processes relies on the ability to mimic the structure or function of cellular proteins. Many viruses encode ubiquitin ligases to facilitate infection, although the mechanisms by which they select their substrates are often unknown. The Herpes Simplex Virus type-1-encoded E3 ubiquitin ligase, ICP0, promotes infection thr...

Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.

Published in Journal of Biological Chemistry

Increased transcriptional activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt-independent regulation is poorly understood. We have demonstrated that AKT, which is activated downstream from epidermal growth factor receptor signal...

Regulation of the Chlamydomonas cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex.

Published in The Plant Cell

We examined the cell cycle dynamics of the retinoblastoma (RB) protein complex in the unicellular alga Chlamydomonas reinhardtii that has single homologs for each subunit-RB, E2F, and DP. We found that Chlamydomonas RB (encoded by MAT3) is a cell cycle-regulated phosphoprotein, that E2F1-DP1 can bind to a consensus E2F site, and that all three prot...

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis...

Published in Molecular Cell

It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is coordinated with suppressed mitochondrial pyruvate metabolism. We demonstrate here that hypoxia, EGFR activation, and expression of K-Ras G12V and B-Raf V600E induce mitochondrial translocation of phosphoglycerate kinase 1 (PGK1); this is mediated by ERK-dep...

Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation.

Published in Nature

Post-translational histone modifications have a critical role in regulating transcription, the cell cycle, DNA replication and DNA damage repair. The identification of new histone modifications critical for transcriptional regulation at initiation, elongation or termination is of particular interest. Here we report a new layer of regulation in tran...

Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation.

Published in Cell

Histidine phosphorylation (pHis) is well studied in bacteria; however, its role in mammalian signaling remains largely unexplored due to the lack of pHis-specific antibodies and the lability of the phosphoramidate (P-N) bond. Both imidazole nitrogens can be phosphorylated, forming 1-phosphohistidine (1-pHis) or 3-phosphohistidine (3-pHis). We have ...