Ji Ho Park

Different effect of hydrogelation on antifouling and circulation properties of dextran-iron oxide nanoparticles.

Published in Molecular Pharmaceutics

Premature recognition and clearance of nanoparticulate imaging and therapeutic agents by macrophages in the tissues can dramatically reduce both the nanoparticle half-life and delivery to the diseased tissue. Grafting nanoparticles with hydrogels prevents nanoparticulate recognition by liver and spleen macrophages and greatly prolongs circulation t...

A surface-charge study on cellular-uptake behavior of F3-peptide-conjugated iron oxide nanoparticles.

Published in Small

Surface-charge measurements of mammalian cells in terms of Zeta potential are demonstrated as a useful biological characteristic in identifying cellular interactions with specific nanomaterials. A theoretical model of the changes in Zeta potential of cells after incubation with nanoparticles is established to predict the possible patterns of Zeta-p...

Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting.

Published in Small

In the design of nanoparticles that can target disease tissue in vivo, parameters such as targeting ligand density, type of target receptor, and nanoparticle shape can play an important role in determining the extent of accumulation. Herein, a systematic study of these parameters for the targeting of mouse xenograft tumors is performed using superp...

Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery.

Published in Angewandte Chemie International Edition in English

Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging.

Published in Advanced Materials

Nanoparticles that communicate in vivo to amplify tumour targeting.

Published in Nature Materials

Nanomedicines have enormous potential to improve the precision of cancer therapy, yet our ability to efficiently home these materials to regions of disease in vivo remains very limited. Inspired by the ability of communication to improve targeting in biological systems, such as inflammatory-cell recruitment to sites of disease, we construct systems...

Contact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo.

Published in Journal of Controlled Release

Previously we reported that plasma kallikrein and high molecular weight kininogen attach to the surface of dextran-coated superparamagnetic iron oxide nanoparticles (SPION) through the incompletely covered iron oxide core (Simberg et al., Biomaterials, 2009). Here we show that SPION also activate kallikrein-kinin system in vitro and in vivo. The se...

Biomimetic amplification of nanoparticle homing to tumors.

Published in Proceedings of the National Academy of Sciences

Nanoparticle-based diagnostics and therapeutics hold great promise because multiple functions can be built into the particles. One such function is an ability to home to specific sites in the body. We describe here biomimetic particles that not only home to tumors, but also amplify their own homing. The system is based on a peptide that recognizes ...

Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads.

Published in Small

Magnetic manipulation, fluorescent tracking, and localized delivery of a drug payload to cancer cells in vitro is demonstrated, using nanostructured porous silicon microparticles as a carrier. The multifunctional microparticles are prepared by electrochemical porosification of a silicon wafer in a hydrofluoric acid-containing electrolyte, followed ...

Nanoparticle amplification <i>via</i> photothermal unveiling of cryptic collagen binding sites.

Published in Journal of Materials Chemistry B

The success of nanoparticle-based cancer therapies ultimately depends on their ability to selectively and efficiently accumulate in regions of disease. Outfitting nanoparticles to actively target tumor-specific markers has improved specificity, yet it remains a challenge to amass adequate therapy in a selective manner. To help address this challeng...

Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications f...

Published in Biomaterials

In order to understand the role of plasma proteins in the rapid liver clearance of dextran-coated superparamagnetic iron oxide (SPIO) in vivo, we analyzed the full repertoire of SPIO-binding blood proteins using novel two-dimensional differential mass spectrometry approach. The identified proteins showed specificity for surface domains of the nanop...

Cooperative nanomaterial system to sensitize, target, and treat tumors.

Published in Proceedings of the National Academy of Sciences

A significant barrier to the clinical translation of systemically administered therapeutic nanoparticles is their tendency to be removed from circulation by the mononuclear phagocyte system. The addition of a targeting ligand that selectively interacts with cancer cells can improve the therapeutic efficacy of nanomaterials, although these systems h...

In vivo tumor cell targeting with "click" nanoparticles.

Published in Bioconjugate Chemistry

The in vivo fate of nanomaterials strongly determines their biomedical efficacy. Accordingly, much effort has been invested into the development of library screening methods to select targeting ligands for a diversity of sites in vivo. Still, broad application of chemical and biological screens to the in vivo targeting of nanomaterials requires lig...

Biodegradable luminescent porous silicon nanoparticles for in vivo applications.

Published in Nature Materials

Nanomaterials that can circulate in the body hold great potential to diagnose and treat disease. For such applications, it is important that the nanomaterials be harmlessly eliminated from the body in a reasonable period of time after they carry out their diagnostic or therapeutic function. Despite efforts to improve their targeting efficiency, sig...

Nanoparticle-induced vascular blockade in human prostate cancer.

Published in Blood

The tumor-homing pentapeptide CREKA (Cys-Arg-Glu-Lys-Ala) specifically homes to tumors by binding to fibrin and fibrin-associated clotted plasma proteins in tumor vessels. Previous results show that CREKA-coated superparamagnetic iron oxide particles can cause additional clotting in tumor vessels, which creates more binding sites for the peptide. W...