Jessica Zucman-Rossi

Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas

Published in Neuroimaging Clinics of North America

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of...

Published in Cell Biology of the B Cell Receptor

The outcome of tumors results from genetic and epigenetic modifications of the transformed cells and also from the interactions of the malignant cells with their tumor microenvironment (TME), which includes immune and inflammatory cells. For a given cancer type, the composition of the immunological TME is not homogeneous. Heterogeneity is found bet...

TERT promoter mutations in primary liver tumors

Published in Annals of the American Thoracic Society

Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis

Published in Hepatology

Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma

Published in Current Genomics

Genotype-phenotype correlation of CTNNB1 mutations reveals different ss-catenin activity associated with liver tumor pro...

Published in Hepatology

Validation of VEGFR1 rs9582036 as predictive biomarker in metastatic clear-cell renal cell carcinoma patients treated wi...

Published in British Journal of Urology

Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV

Published in The American Journal of Sports Medicine

AAV2 and Hepatocellular Carcinoma

Published in Behavioral and Brain Functions

Translating the molecular diversity of hepatocellular carcinoma into clinical practice

Published in Current Genomics

Toward understanding and exploiting tumor heterogeneity.

Published in Journal of Neuroscience Research

The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Bio...

Mutations leading to constitutive active gp130/JAK1/STAT3 pathway

Published in Questions de communication

Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

Published in International Archives of Orthopedic Surgery

RANK/OPG ratio of expression in primary clear-cell renal cell carcinoma is associated with bone metastasis and prognosis...

Published in International Journal of Nanomedicine

DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma.

Published in The Journal of Clinical Endocrinology & Metabolism

A validated signature of 36 DNA methylation markers accurately predicts poor survival in patients with HCC. Patients with this methylation profile harbor messenger RNA-based signatures indicating tumors with progenitor cell features.

Integration of tumour and viral genomic characterizations in HBV-related hepatocellular carcinomas.

Published in Journal of Neurology Neurosurgery & Psychiatry

Integrated genomic characterisation of HBV and non-HBV-related HCC emphasised the immense molecular diversity of HCC closely related to aetiologies that could impact clinical care of HCC patients.

Authors' response: virus-host interactions in HBV-related hepatocellular carcinoma: more to be revealed?

Published in Journal of Neurology Neurosurgery & Psychiatry

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.

Published in BAOJ Pediatrics

Genomic analyses promise to improve tumor characterization to optimize personalized treatment for patients with hepatocellular carcinoma (HCC). Exome sequencing analysis of 243 liver tumors identified mutational signatures associated with specific risk factors, mainly combined alcohol and tobacco consumption and exposure to aflatoxin B1. We identif...

Unique genomic profile of fibrolamellar hepatocellular carcinoma.

Published in PLoS Genetics

In a genomic analysis of 78 FLC samples, we identified 3 classes based on gene expression profiles. FLCs contain mutations and chromosomal aberrations not previously associated with liver cancer, and almost 80% contain the DNAJB1-PRKACA fusion transcript. By using this information, we identified a gene signature that is associated with patient surv...