Jean-Pierre Hugot

Respective Roles of Hematopoietic and Nonhematopoietic Nod2 on the Gut Microbiota and Mucosal Homeostasis

Published in Acta Crystallographica Section F Structural Biology and Crystallization Communications

Molecular data and ecological niche modelling reveal the evolutionary history of the common and Iberian moles (Talpidae)...

According to mitochondrial data, the common mole, Talpa europaea, is paraphyletic. This could be explained by either an ancient introgression of mtDNA from the Iberian blind mole T. occidentalis to T. europaea, or the existence of a differentiated taxonomic entity in northern Spain that needs to be described. In this study, we combined mitochondria...

Inflammatory bowel disease after allogeneic stem cell transplantation

Published in International Journal of Molecular Sciences

Microvillous atrophy: atypical presentations.

Published in SLEEP

This study extends the spectrum of MVID to less severe clinical presentations.

Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carr...

Published in Zeszyty Naukowe WCO Letters in Oncology Science

Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerativ...

Published in PLoS ONE

Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease

Published in JACC Cardiovascular Imaging

Discovery of a 240 million year old nematode parasite egg in a cynodont coprolite sheds light on the early origin of pin...

Published in Journal of Radiation Protection and Research

From the coprolite examined, we discovered an egg representing a new species of pinworm that, based on the egg structure, clearly places it in the family Heteroxynematidae. Nematodes of the order Oxyurida have very constrained life-histories, occurring only in animals that are not strictly carnivorous and also ingest large amounts of plant material...

Celiac disease in the Mediterranean area.

BACKGROUND: The World Gastroenterology Organization recommends developing national guidelines for the diagnosis of Celiac Disease (CD): hence a profile of the diagnosis of CD in each country is required. We aim to describe a cross-sectional picture of the clinical features and diagnostic facilities in 16 countries of the Mediterranean basin. Since ...

Identification of a novel assemblage G subgenotype and a zoonotic assemblage B in rodent isolates of Giardia duodenalis ...

Published in British Journal Of Nutrition

The flagellated parasite Giardia duodenalis is known as one of the most common causes of protozoal diarrhoea in both humans and animals worldwide. The aim of the present work was to perform the first study of G. duodenalis in rodents in the Canary Islands (Spain) and analyse the level of genetic variation and the potential zoonotic role of the isol...

Genetic characterization of congenital tufting enteropathy: epcam associated phenotype and involvement of SPINT2 in the ...

: Congenital tufting enteropathy (CTE) is a rare and severe enteropathy recently ascribed to mutations in the epcam gene. Here we establish SPINT2, previously ascribed to congenital sodium diarrhea, as a second gene associated with CTE and report molecular and immunohistochemistry data in 57 CTE patients. Inclusion criteria were early onset diarrhe...

Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease.

Published in Archives of Pediatrics and Adolescent Medicine

These findings suggest that a variant of the CLDN2-MORC4 region predisposes to CD in a Swedish population.

Impact du gène NOD2 sur l'homéostasie du microbiote et de la muqueuse intestinale

FR

Molecular reclassification of Crohn's disease: a cautionary note on population stratification.

Peer reviewed

Management of pediatric ulcerative colitis: joint ECCO and ESPGHAN evidence-based consensus guidelines.

Published in SLEEP

These guidelines provide clinically useful points to guide the management of UC in children. Taken together, the recommendations offer a standardized protocol that allows effective, timely management and monitoring of the disease course, while acknowledging that each patient is unique.

Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling

Published in European Journal of Human Genetics

Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease

Published in PLoS Genetics

Genotype/Phenotype analyses for 53 Crohn's disease associated genetic polymorphisms.

UNLABELLED: BACKGROUND #ENTITYSTARTX00026; AIMS: Recent studies reported a role for more than 70 genes or loci in the susceptibility to Crohn's disease (CD). However, the impact of these associations in clinical practice remains to be defined. The aim of the study was to analyse the relationship between genotypes and phenotypes for the main 53 CD-a...

Etude de l'autophagie dans la maladie de Crohn

FR

Trace-element deficiencies in microvillous inclusion disease.

Published in SLEEP