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Alnabhani, Ziad Jean-Pierre Hugot Montcuquet, Nicolas Le Roux, Karine Dussaillant, Monique Roy, Maryline Leclerc, Marion Nadine Cerf-Bensussan Lepage, Patricia Barreau, Frédérick
...
Published in
Inflammatory Bowel Diseases
Background: NOD2 mutations are associated with Crohn's disease (CD). Both CD (in human) and Nod2 deficiency (in mice) are characterized by increased mucosal CD4 T-cells, an altered permeability and a microbial dysbiosis. However, the respective roles of the gut epithelial and immune compartments on the phenotype are not known.
Methods: Microbial...
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Nicolas, Violaine Martínez-Vargas, Jessica Jean-Pierre Hugot
According to mitochondrial data, the common mole, Talpa europaea, is paraphyletic. This could be explained by either an ancient introgression of mtDNA from the Iberian blind mole T. occidentalis to T. europaea, or the existence of a differentiated taxonomic entity in northern Spain that needs to be described. In this study, we combined mitochondria...
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Boussen, I Sokol, H Aractingi, S Georges, O Hoyeau-Idrissi, N Jean-Pierre Hugot Mohty, M Rubio, M T
Published in
International Journal of Molecular Sciences
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Perry, Ariane Bensallah, Hayet Martinez-Vinson, Christine Berrebi, Dominique Arbeille, Brigitte Salomon, Julie Goulet, Olivier Marinier, Evelyne Drunat, Séverine Samson-Bouma, Marie-Elisabeth
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Published in
SLEEP
This study extends the spectrum of MVID to less severe clinical presentations.
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Aguilar, Claire Lenoir, Christelle Lambert, Nathalie Bègue, Bernadette Brousse, Nicole Canioni, Danielle Berrebi, Dominique Roy, Maryline Gérart, Stéphane Chapel, Helen
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Published in
Zeszyty Naukowe WCO Letters in Oncology Science
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Tréton, Xavier Pedruzzi, Eric Guichard, Cécile Yannick Ladeiro Sedghi, Shirin Vallée, Mélissa Fernandez, Neike Bruyère, Emilie Woerther, Paul-Louis Ducroc, Robert
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Published in
PLoS ONE
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Ruemmele, F.M. Veres, G. Kolho, K.L. Griffiths, A. Levine, A. Escher, J.C. Amil Dias, J. Barabino, A. Braegger, C.P. Bronsky, J.
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Published in
JACC Cardiovascular Imaging
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Jean-Pierre Hugot Gardner, Scott L Borba, Victor Araujo, Priscilla Leles, Daniela Stock Da-Rosa, Átila Augusto Dutra, Juliana Ferreira, Luiz Fernando Araújo, Adauto
Published in
Journal of Radiation Protection and Research
From the coprolite examined, we discovered an egg representing a new species of pinworm that, based on the egg structure, clearly places it in the family Heteroxynematidae. Nematodes of the order Oxyurida have very constrained life-histories, occurring only in animals that are not strictly carnivorous and also ingest large amounts of plant material...
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Tucci, Francesca Astarita, Luca Abkari, Abdelhak Abu-Zekry, Mona Attard, Thomas Ben Hariz, Mongi Bilbao, José Ramon Boudraa, Ghazalia Boukthir, Samir Costa, Stefano
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BACKGROUND: The World Gastroenterology Organization recommends developing national guidelines for the diagnosis of Celiac Disease (CD): hence a profile of the diagnosis of CD in each country is required. We aim to describe a cross-sectional picture of the clinical features and diagnostic facilities in 16 countries of the Mediterranean basin. Since ...
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Fernández-Álvarez, Ángela Martín-Alonso, Aarón Abreu-Acosta, Néstor Feliu, Carlos Jean-Pierre Hugot Valladares, Basilio Foronda, Pilar
Published in
British Journal Of Nutrition
The flagellated parasite Giardia duodenalis is known as one of the most common causes of protozoal diarrhoea in both humans and animals worldwide. The aim of the present work was to perform the first study of G. duodenalis in rodents in the Canary Islands (Spain) and analyse the level of genetic variation and the potential zoonotic role of the isol...
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Salomon, Julie Goulet, Olivier Canioni, Danielle Brousse, Nicole Lemale, Julie Tounian, Patrick Coulomb, Aurore Marinier, Evelyne Jean-Pierre Hugot Ruemmele, Frank
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Published in
Human Genetics
Congenital tufting enteropathy (CTE) is a rare and severe enteropathy recently ascribed to mutations in the epcam gene. Here we establish SPINT2, previously ascribed to congenital sodium diarrhea, as a second gene associated with CTE and report molecular and immunohistochemistry data in 57 CTE patients. Inclusion criteria were early onset diarrhea ...
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Söderman, Jan Norén, Elisabeth Christiansson, Malin Bragde, Hanna Thiébaut, Raphaele Jean-Pierre Hugot Tysk, Curt O'Morain, Colm A Gassull, Miquel Finkel, Yigael
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Published in
Archives of Pediatrics and Adolescent Medicine
These findings suggest that a variant of the CLDN2-MORC4 region predisposes to CD in a Swedish population.
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ALNABHANI, Ziad Jean-Pierre Hugot BARREAU, Frédérick
FR
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Maus, Barbel Jung, Camille Mahachie John, Jestinah Jean-Pierre Hugot Genin, Emmanuelle Van Steen, Kristel
Peer reviewed
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Jung, Camille Colombel, Jean-Frédéric Lemann, Marc Beaugerie, Laurent Matthieu Allez Cosnes, Jacques Vernier-Massouille, Gwenola Gornet, Jean-Marc Gendre, Jean-Pierre Cezard, Jean-Pierre
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Published in
PLoS ONE
BACKGROUND & AIMS: Recent studies reported a role for more than 70 genes or loci in the susceptibility to Crohn's disease (CD). However, the impact of these associations in clinical practice remains to be defined. The aim of the study was to analyse the relationship between genotypes and phenotypes for the main 53 CD-associated polymorphisms. METHO...
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Jean-Pierre Hugot Kolacek, Sanja Kolho, Kaija Leena Lionetti, Paolo Paerregaard, Anders Potapov, Alexander Rintala, Risto Serban, Daniela E Staiano, Annamaria Sweeny, Brian
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Published in
SLEEP
These guidelines provide clinically useful points to guide the management of UC in children. Taken together, the recommendations offer a standardized protocol that allows effective, timely management and monitoring of the disease course, while acknowledging that each patient is unique.
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Thachil, Élodie Jean-Pierre Hugot Arbeille, Brigitte Paris, Régine Grodet, Alain Peuchmaur, Michel Patrice Codogno Barreau, Frédérick Eric Ogier-Denis Berrebi, Dominique
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Published in
PLoS Genetics
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Jung, Camille Meinzer, Ulrich Montcuquet, Nicolas Thachil, Elodie Château, Danielle Thiébaut, Raphaële Roy, Maryline Alnabhani, Ziad Berrebi, Dominique Dussaillant, Monique
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Published in
Journal of Clinical Investigation
Intestinal barrier function requires intricate cooperation between intestinal epithelial cells and immune cells. Enteropathogens are able to invade the intestinal lymphoid tissue known as Peyer's patches (PPs) and disrupt the integrity of the intestinal barrier. However, the underlying molecular mechanisms of this process are poorly understood. In ...
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THACHIL, Elodie Jean-Pierre Hugot
FR
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Halac, Ugur Lacaille, Florence Joly, Francisca Jean-Pierre Hugot Talbotec, Cécile Colomb, Virginie Ruemmele, Frank Goulet, Olivier
Published in
SLEEP