Francine Acher

Neurochemical and behavioral studies on the 5-HT1A-dependent antipsychotic action of the mGlu4 receptor agonist LSP4-202...

Published in Journal of Biopharmaceutical Statistics

Involvement of GABAB Receptor Signaling in Antipsychotic-like Action of the Novel Orthosteric Agonist of the mGlu4 Recep...

Published in Developmental Dynamics

Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network

Published in Nature Reviews Drug Discovery

Allosteric modulation of metabotropic glutamate receptors by chloride ions

Published in The FASEB Journal

A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action

Published in Journal of Biopharmaceutical Statistics

Therapeutic potential of group III metabotropic glutamate receptor ligands in pain

Published in Annals of Oncology

Determination of the absolute configuration of phosphinic analogues of glutamate

Published in Archives of Pediatrics and Adolescent Medicine

Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the b...

Published in Human Mutation

Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly expressed in the presynaptic active zones of both excitatory and inhibitory synapses, and activation of the receptor regulates the release of both glutamate and GABA. mGlu7 is thought to be a ...

Molecular determinants of agonist selectivity in glutamate-gated chloride channels which likely explain the agonist sele...

Published in PLoS ONE

Qualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist.

Published in European Journal of Heart Failure

LSP1-2111 is a group III metabotropic glutamate receptor agonist with preference toward the mGlu4 receptor subtype. This compound has been extensively used as a tool to explore the pharmacology of mGlu4 receptor activation in preclinical animal behavioral models. However, the blood-brain barrier penetration of this amino acid derivative has never b...

Tandem triad systems based on FRET for two-photon induced release of glutamate.

Published in Human Molecular Genetics

Tandem systems allowing enhanced two-photon (2P) absorption in a wavelength range permitting coupling of the primary excitation by energy transfer to an intramolecular cage known to have fragmentation properties suited to photolysis in neuroscience is demonstrated to lead to a 10-fold improvement in the 2P photolysis cross-section at experimentally...

Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.

Published in American Heart Journal

Hyperactivity of the glutamatergic system is involved in the development of central sensitization in the pain neuraxis, associated with allodynia and hyperalgesia observed in patients with chronic pain. Herein we study the ability of type 4 metabotropic glutamate receptors (mGlu4) to regulate spinal glutamate signaling and alleviate chronic pain. W...

The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT(1)A signalling

Published in Seminars in Arthritis and Rheumatism

Role of mGluR4 in acquisition of fear learning and memory

Published in Journal of Biopharmaceutical Statistics

Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor

Published in Investigational New Drugs

Variations on glutamate binding in channel-gated receptors

Published in Structure

Orthosteric versus allosteric GPCR activation: the great challenge of group-III mGluRs

Published in Experimental Cell Research

Synthesis of quinoline dicarboxylic esters as biocompatible fluorescent tags

Published in International Archives of Cardiovascular Diseases

Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of ...

Published in Seminars in Arthritis and Rheumatism

Modulateurs du transport vésiculaire du glutamate (développement d'outils pharmacologiques et de diagnostic pour la mala...

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