Neurochemical and behavioral studies on the 5-HT1A-dependent antipsychotic action of the mGlu4 receptor agonist LSP4-202...
Published in Journal of Biopharmaceutical Statistics
Published in Journal of Biopharmaceutical Statistics
Published in Developmental Dynamics
Published in Nature Reviews Drug Discovery
Published in The FASEB Journal
Published in Journal of Biopharmaceutical Statistics
Published in Annals of Oncology
Published in Archives of Pediatrics and Adolescent Medicine
Published in Human Mutation
Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly expressed in the presynaptic active zones of both excitatory and inhibitory synapses, and activation of the receptor regulates the release of both glutamate and GABA. mGlu7 is thought to be a ...
Published in PLoS ONE
Published in European Journal of Heart Failure
LSP1-2111 is a group III metabotropic glutamate receptor agonist with preference toward the mGlu4 receptor subtype. This compound has been extensively used as a tool to explore the pharmacology of mGlu4 receptor activation in preclinical animal behavioral models. However, the blood-brain barrier penetration of this amino acid derivative has never b...
Published in Human Molecular Genetics
Tandem systems allowing enhanced two-photon (2P) absorption in a wavelength range permitting coupling of the primary excitation by energy transfer to an intramolecular cage known to have fragmentation properties suited to photolysis in neuroscience is demonstrated to lead to a 10-fold improvement in the 2P photolysis cross-section at experimentally...
Published in American Heart Journal
Hyperactivity of the glutamatergic system is involved in the development of central sensitization in the pain neuraxis, associated with allodynia and hyperalgesia observed in patients with chronic pain. Herein we study the ability of type 4 metabotropic glutamate receptors (mGlu4) to regulate spinal glutamate signaling and alleviate chronic pain. W...
Published in Seminars in Arthritis and Rheumatism
Published in Journal of Biopharmaceutical Statistics
Published in Investigational New Drugs
Published in Structure
Published in Experimental Cell Research
Published in International Archives of Cardiovascular Diseases
Published in Seminars in Arthritis and Rheumatism
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