Publications - Esma Yagdi - Page 1

Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal c...

Esma Yagdi Mazumder, Aloran Lee, Jin-Young Anthoula Gaigneaux Flavia Radogna Nasim, Muhammad Jawad Christov, Christo Jacob, Claus Kim, Kyu-Won Dicato, Mario ...

Published in Cancer Letters

Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...

Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?

Esma Yagdi Claudia Cerella Dicato, Mario Marc Diederich

Published in Food and Chemical Toxicology

In vitro and in vivo studies reported the anti-cancer potential of organosulfur compounds (OSCs) as they trigger biological effects leading to cell cycle arrest with accumulation of cells in G2/M, alteration of the microtubular network, modulation of Bcl-2 family protein expression patterns and changes of the redox status. Despite these well-descri...