Ekama Onofiok

The “One-Bead-One-Compound” Combinatorial Approach to Identifying Molecular Imaging Probes

A novel hydrogel functionalized with specific peptidomimetic ligands for 2-D and 3-D cell culture.

Published in Advances in experimental medicine and biology

Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.

Published in Science Signaling

Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an afterload during cardiomyocyte contraction, we found that nitric oxide synthase (NOS) was involved in transducing mechanical load to alter Ca(2+) dynamics. In mouse ventricular ...