The “One-Bead-One-Compound” Combinatorial Approach to Identifying Molecular Imaging Probes
Published in Advances in experimental medicine and biology
Published in Science Signaling
Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an afterload during cardiomyocyte contraction, we found that nitric oxide synthase (NOS) was involved in transducing mechanical load to alter Ca(2+) dynamics. In mouse ventricular ...