Daniel Zytnicki

Potassium currents dynamically set the recruitment and firing properties of F-type motoneurons in neonatal mice

Published in Revue Tiers Monde

Is hyperexcitability really guilty in amyotrophic lateral sclerosis?

Published in European Urology

Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

Published in Current Opinion in Immunology

The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing b...

Published in The Lancet

Spinal motoneurons may display a variety of firing patterns including bistability between repetitive firing and quiescence and, more rarely, bistability between two firing states of different frequencies. It was suggested in the past that firing bistability required that the persistent L-type calcium current be segregated in distal dendrites, far a...

Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis.

Published in Sexually Transmitted Diseases

In amyotrophic lateral sclerosis (ALS), an adult onset disease in which there is progressive degeneration of motoneurones, it has been suggested that an intrinsic hyperexcitability of motoneurones (i.e. an increase in their firing rates), contributes to excitotoxicity and to disease onset. Here we show that there is no such intrinsic hyperexcitabil...

Differential abnormalities of two spinal motoneuron populations in the SOD1 G93A neonatal mouse (model of the amyotrophi...

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Alpha, beta and gamma motoneurons: functional diversity in the motor system's final pathway.

Published in The Journal of Clinical Endocrinology & Metabolism

Since their discovery in the late 19th century our conception of motoneurons has steadily evolved. Motoneurons share the same general function: they drive the contraction of muscle fibers and are the final common pathway, i.e., the seat of convergence of all the central and peripheral pathways involved in motricity. However, motoneurons innervate d...

Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state.

Published in American Heart Journal

We explain the mechanism that elicits the mixed mode oscillations (MMOs) and the subprimary firing range that we recently discovered in mouse spinal motoneurons. In this firing regime, high-frequency subthreshold oscillations appear a few millivolts below the spike voltage threshold and precede the firing of a full blown spike. By combining intrace...

Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons.

Published in American Heart Journal

The fast contraction time of mouse motor units creates a unique situation in which motoneurons have to fire at low frequencies to produce small forces but also at very high frequency (much higher than in cat or rat motoneurons) to reach the fusion frequency of their motor units. To understand how this problem is solved, we performed intracellular r...

Interaction des courants entrants persistants avec le courant Ih et le courant d'AHP dans les motoneurones spinaux (cons...

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Contribution à l'étude des rôles respectifs des afférences proprioceptives et des propriétés membranaires postsynaptique...

FR

La sensibilite dynamique des organes tendineux de Golgi et son role dans la detection des variations de la force contrac...

France