Daniel Hsu

Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells

Published in Journal of Investigative Dermatology Symposium Proceedings

Galectin-3 negatively regulates TCR-mediated CD4+ T cell activation at the immunological synapse

Published in Proc Natl Acad Sci

Galectin-3 regulates T cells

Published in Immunological Reviews

Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis

Published in American Journal Of Pathology

Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation

Published in Journal of Investigative Dermatology Symposium Proceedings

Role of galectin-3 in mast cell functions. Galectin-3-deficient mast cells exhibit impaired mediator release and defecti...

Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology

Galectin-12 is Required for Adipogenic Signaling and Adipocyte Differentiation

Published in JBIC Journal of Biological Inorganic Chemistry

Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma

Published in American Journal Of Pathology

Critical role of galectin-3 in phagocytosis by macrophages

Published in Journal of Investigational Allergology and Clinical Immunology

Galectin-7 (PIG1:p53-induced gene 1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome...

Published in JBIC Journal of Biological Inorganic Chemistry

Cell cycle regulation by galectin-12, a new member of the galectin superfamily

Published in JBIC Journal of Biological Inorganic Chemistry

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology

Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses

Published in American Journal Of Pathology

Toxoplasma gondii infection reveals a dual role for galectin-3 on innate and adaptive immune response

Published in American Journal Of Pathology

Galectin-3 regulates T-cell functions.

Published in Immunological Reviews

Galectin-3 is absent in resting CD4+ and CD8+ T cells but is inducible by various stimuli. These include viral transactivating factors, T-cell receptor (TCR) ligation, and calcium ionophores. In addition, galectin-3 is constitutively expressed in human regulatory T cells and CD4+ memory T cells. Galectin-3 exerts extracellular functions because of ...

Analysis of the intracellular role of galectins in cell growth and apoptosis.

Published in Methods in Molecular Biology

Galectins are a family of animal lectins with conserved carbohydrate-recognition domains that recognize β-galactosides. Despite structural similarities, these proteins have diverse functions in a variety of cellular processes. While a large number of extracellular functions have been demonstrated for galectins, the existence of intracellular functi...

Galectin-3 modulates Th17 responses by regulating dendritic cell cytokines.

Published in American Journal Of Pathology

Galectin-3 is a β-galactoside-binding animal lectin with diverse functions, including regulation of T helper (Th) 1 and Th2 responses. Current data indicate that galectin-3 expressed in dendritic cells (DCs) may be contributory. Th17 cells have emerged as critical inducers of tissue inflammation in autoimmune disease and important mediators of host...

Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds.

Published in Journal of Biological Chemistry

Disorders of wound healing characterized by impaired or delayed re-epithelialization are a serious medical problem. These conditions affect many tissues, are painful, and are difficult to treat. In this study, using cornea as a model, we demonstrate for the first time the importance of carbohydrate-binding proteins galectins-3 and -7 in re-epitheli...

Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration.

Published in Journal of Investigative Dermatology

The EGFR-mediated signaling pathways are important in a variety of cellular processes, including cell migration and wound re-epithelialization. Intracellular trafficking of EGFR is critical for maintaining EGFR surface expression. Galectin-3, a member of an animal lectin family, has been implicated in a number of physiological and pathological proc...

Galectin-3 Plays an Important Role in Innate Immunity to Gastric Infection by Helicobacter pylori.

Published in Infection and Immunity

We studied the role of galectin-3 (Gal3) in gastric infection by Helicobacter pylori We first demonstrated that Gal3 was selectively expressed by gastric surface epithelial cells and abundantly secreted into the surface mucus layer. We next inoculated H. pylori Sydney strain 1 into wild-type (WT) and Gal3-deficient mice using a stomach tube. At 2 w...