Inflammation regulates long non-coding RNA-PTTG1-1:1 in myeloid leukemia.
Published in Haematologica
No abstract available
Inflammation regulates long non-coding RNA-PTTG1-1:1 in myeloid leukemia.
Natural and Synthetic Flavonoids: Structure–Activity Relationship and Chemotherapeutic Potential for the Treatment of Le...
Published in Critical Reviews in Food Science and Nutrition
Flavonoids and their derivatives are polyphenolic secondary metabolites with an extensive spectrum of pharmacological activities, including antioxidants, antitumor, anti-inflammatory, and antiviral activities. These flavonoids can also act as chemopreventive agents by their interaction with different proteins and can play a vital role in chemothera...
Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Ob...
Published in Marine Drugs
Part of our ocean's richness comes from its extensive history of supporting life, resulting in a highly diverse ecological system. To date, over 250,000 species of marine organisms have been identified, but it is speculated that the actual number of marine species exceeds one million, including several hundreds of millions of species of marine micr...
Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces cejpii with NF-κB Inhibitory Potential
Published in Marine Drugs
The Ascomycota Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. A new gliotoxin derivative, 6-acetylmonodethiogliotoxin (1) was obtained from fungal extracts. Compounds 2 and 3, methylthio-gliotoxin derivatives were formerly only known as semi-synthetic compounds and are here described as natural products. Addi...
Metabolism 2014 – Alterations of metabolic pathways as therapeutic targets
Published in Biochemical Pharmacology
N/A
Synthesis and bioactivity of novel amino-pyrazolopyridines
Published in European Journal of Medicinal Chemistry
Here we describe the synthesis and biological activity of novel amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential. α-Methylene ketones were used as a starting point for synthesis of amino-pyrazolopyridine 3. The alkylidene malononitriles 1 were obtained by the Knoevenagel reaction of ketones with malononitriles. Vilsmeier-Haack re...
Inhibitory effect of St. John׳s Wort oil macerates on TNFα-induced NF-κB activation and their fatty acid composition
Published in Journal of Ethnopharmacology
The oil macerates of Hypericum perforatum L. (St. John's Wort=SJW) has a long history of medicinal use and SJW has been used in traditional medicine both orally and topically for centuries worldwide mainly for wound healing, ulcer and inflammation.
Methylenedioxy flavonoids: Assessment of cytotoxic and anti-cancer potential in human leukemia cells
Published in European Journal of Medicinal Chemistry
A new series of chalcones, flavanones and flavones with methylenedioxy group at the 3',4' position in chalcone, 7,8 position in flavanones and flavones with mono-, di- and trimethoxy groups in the benzaldehyde ring have been assessed for their effect on proliferation, cytotoxic potential and apoptosis in human leukemia cells. Among the tested compo...
Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation...
Published in Molecules
Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viabili...
Anti-Inflammatory and Anticancer Drugs from Nature
Published in Cancer Treatment and Research
Over the centuries, plant extracts have been used to treat various diseases. Until now, natural products have played an important role in anticancer therapy as there are more than 500 compounds from terrestrial and marine plants or microorganisms, which have antioxidant, antiproliferative, or antiangiogenic properties and are therefore able to redu...
Styryl-lactone goniothalamin inhibits TNF-α-induced NF-κB activation
Published in Food and Chemical Toxicology
(R)-(+)-Goniothalamin (GTN), a styryl-lactone isolated from the medicinal plant Goniothalamus macrophyllus, exhibits pharmacological activities including cytotoxic and anti-inflammatory effects. In this study, GTN modulated TNF-α induced NF-κB activation. GTN concentrations up to 20 μM showed low cytotoxic effects in K562 chronic myelogenous leukem...
1,000 Ways to die: natural compounds modulate non-canonical cell death pathways in cancer cells
Published in Phytochemistry Reviews
Over the past decades, apoptosis emerged as a leading strategy to eliminate cancer cells. Nowadays, it becomes progressively clear that apoptosis is not the only programmed cell death mechanism implicated in the elimination of malignant cells. This review will discuss non-apoptotic cell death modalities and will focus on natural compounds acting as...
Embellicines A and B: Absolute Configuration and NF-κB Transcriptional Inhibitory Activity
Published in Journal of Medicinal Chemistry
Two new metabolites, embellicines A and B (1 and 2), were isolated from the EtOAc extract of the fungus Embellisia eureka, an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of extensive one- and two-dimensional NMR spectroscopy as well as by high-resolution mass s...
The aromatic ketone 4′-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition
Published in Biochemical Pharmacology
Chalcones are aromatic ketones, known to exhibit anti-microbial, anti-inflammatory and anti-cancer activities. The aim of this study was to investigate the anti-inflammatory and anti-cancer activity of 4'-hydroxychalcone. Here, we report that 4'-hydroxychalcone inhibits TNFα-induced NF-κB pathway activation in a dose-dependent manner. To investigat...
Dietary chalcones with chemopreventive and chemotherapeutic potential
Published in Genes & Nutrition
Chalcones are absorbed in the daily diet and appear to be promising cancer chemopreventive agents. Chalcones represent an important group of the polyphenolic family, which includes a large number of naturally occurring molecules. This family possesses an interesting spectrum of biological activities, including antioxidative, antibacterial, anti-inf...
NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tub...
Published in Bioorganic & Medicinal Chemistry
Chemical investigation of the endophytic fungus Penicillium sp. isolated from Limonium tubiflorum growing in Egypt afforded four new compounds of polyketide origin, including two macrolides, penilactone (1) and 10,11-epoxycurvularin (2), a dianthrone, neobulgarone G (7), and a sulfinylcoumarin, sulfimarin (14), along with twelve known metabolites (...
Decrypting the labyrinth of inflammatory cell signaling pathways
Published in Journal of Cell Communication and Signaling
Following the tradition since 1998, the “Inflammation 2010” meeting was organized again in Luxembourg and gathered more than 550 scientists and exhibitors. The gorgeous, brand-new Conference Centre Kirchberg opened its doors for the first time to honor the guests of the “Inflammation 2010” meeting. Besides the enthusiastic talks and discussions, mo...
Naturally Occurring Regulators of Histone Acetylation/Deacetylation
Published in Current Topics in Medicinal Chemistry
Acetylation and deacetylation of lysine residues on histones, which are catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), are epigenetic modifications that play a very important role in the regulation of gene transcription. Perturbation of the balance between histone acetylation and deacetylation leads to a myriad of ...
