Published in Molecules in September 2016
A graphical abstract (GA) represents a piece of artwork that is intended to summarize the main findings of an article for readers at a single glance. Many publishers currently encourage authors to supplement their articles with GAs, in the hope that such a convenient visual summary will facilitate readers with a clearer outline of papers that are o...
Published in Journal of Natural Products in Oct 21, 2010
in Jan 01, 2003
Abstract Dithiocarbamates (DTCs), important therapeutic and industrial chemicals released in high quantities into the environment, exhibit complex chemical and biological activities. Here, we demonstrate an effect of DTCs on glucocorticoid action due to inhibition of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2, converting cortisol to cortis...
Published in Molecular and Cellular Endocrinology in Jan 01, 2003
Abstract A rapid screening assay for chemicals inhibiting 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 or type 2 using lysates from stably transfected cells was developed. Here, we tested a series of environmental chemicals for anti-11β-HSD activities. Inhibition of 11β-HSD2, which may cause cortisol-dependent activation of the mineralocor...
Published in Biotechnology advances
Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification of novel drug leads. In the past decades, pharmaceutical industry focused mainly on libraries of synthetic compounds as drug discovery source. They are comparably easy to pr...