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Esma Yagdi Mazumder, Aloran Lee, Jin-Young Anthoula Gaigneaux Flavia Radogna Nasim, Muhammad Jawad Christov, Christo Jacob, Claus Kim, Kyu-Won Dicato, Mario
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Published in
Cancer Letters
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
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Flavia Radogna Claudia Cerella Anthoula Gaigneaux Christov, C. Dicato, Mario Marc Diederich
Published in
Oncogene
A limiting factor in the therapeutic outcome of children with high-risk neuroblastoma is the intrinsic and acquired resistance to common chemotherapeutic treatments. Here we investigated the molecular mechanisms by which the hemisynthetic cardiac glycoside UNBS1450 overcomes this limitation and induces differential cell death modalities in both neu...
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Claudia Cerella Florian Muller Anthoula Gaigneaux Flavia Radogna Viry, Elodie Sébastien Chateauvieux Dicato, Mario Marc Diederich
Published in
Cell Death and Disease
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na + /K +)-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis pr...
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Claudia Cerella Anthoula Gaigneaux Dicato, Mario Marc Diederich
Published in
Cancer Letters
Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter ...
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Trécul, Anne Franck Morceau Anthoula Gaigneaux Michael Schnekenburger Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Valproic acid (VPA) exhibits important pharmacological properties but has been reported to trigger side effects, notably on the hematological system. We previously reported that VPA affects hematopoietic homeostasis by inhibiting erythroid differentiation and promoting myeloid and megakaryocyte differentiation. Here, we analyzed the effect of VPA o...
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Cindy Grandjenette Michael Schnekenburger Karius, Tommy Ghelfi, Jenny Anthoula Gaigneaux Henry, Estelle Dicato, Mario Marc Diederich
Increased proliferation rates as well as resistance to apoptosis are considered major obstacles for the treatment of patients with chronic myelogenous leukemia (CML), thus highlighting the need for novel therapeutic approaches. Since senescence has been recognized as a physiological barrier against tumorigenesis, senescence-based therapy could repr...
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El Amrani, Mustapha Lai, Daowan Debbab, Abdessamad Aly, Amal H. Siems, Karsten Seidel, Carole Michael Schnekenburger Anthoula Gaigneaux Marc Diederich Feger, Daniel
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Published in
Journal of Natural Products
A chemical investigation of the endophytic fungus Epicoccum nigrum isolated from leaves of Mentha suaveolens collected in Morocco resulted in the isolation of five new polyketides, epicocconigrones A and B (1 and 2), 3-methoxyepicoccone B (3), 3-methoxyepicoccone (4), and 2,3,4-trihydroxy-6-(methoxymethyl)-5-methylbenzaldehyde (5), together with fi...
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Trécul, Anne Franck Morceau Anthoula Gaigneaux Marion Orsini Sébastien Chateauvieux Cindy Grandjenette Dicato, Mario Marc Diederich
Published in
Cancer Letters
Constitutive activity of kinases has been reported in many types of cancers, so that inhibition of "onco-kinases" became a validated anti-cancer strategy. We found that the polyphenol 13c, a tri-vanillate derivative, inhibited kinase phosphorylation in leukemia cells. P-JAK2, P-Src and P-PI3Kp85 inhibition occurred independently of phosphatase invo...
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Anthoula Gaigneaux Goormaghtigh, E.
Published in
The Analyst
The multiresistant phenotype is an important problem in cancer chemotherapy. It is characterized by cell resistance to multiple and structurally unrelated drugs. We have shown previously that K562 multiresistant leukemia cells could be differentiated from their sensitive counterparts (wild-type K562 cells) on the basis of their infrared spectrum. I...
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De Bosscher, Karolien Beck, Ilse M. Dejager, Lien Bougarne, Nadia Anthoula Gaigneaux Sébastien Chateauvieux Ratman, Dariusz Bracke, Marc Tavernier, Jan Vanden Berghe, Wim
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Published in
Cellular and Molecular Life Sciences
Glucocorticoids (GCs) block inflammation via interference of the liganded glucocorticoid receptor (GR) with the activity of pro-inflammatory transcription factors NF-κB and AP-1, a mechanism known as transrepression. This mechanism is believed to involve the activity of GR monomers. Here, we explored how the GR monomer-favoring Compound A (CpdA) af...
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Marie-Hélène Teiten Anthoula Gaigneaux Sébastien Chateauvieux Billing, Anja M. Planchon, Sébastien Fack, Fred Renaut, Jenny Mack, Fabienne Muller, Claude P. Dicato, Mario
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Published in
OMICS A Journal of Integrative Biology
Due to high prevalence and slow progression of prostate cancer, primary prevention appears to be attractive strategy for its eradication. During the last decade, curcumin (diferuloylmethane), a natural compound from the root of turmeric (Curcuma longa), was described as a potent chemopreventive agent. Curcumin exhibits anti-inflammatory, anticarcin...
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Anthoula Gaigneaux Decaestecker, C. Camby, I. Mijatovic, T. Kiss, Robert Ruysschaert, J.M Goormaghtigh, E.
Published in
Experimental Cell Research
The present research investigates whether infrared spectra can be related to the biological characteristics of glioma cell lines. We used nine human glioma cell lines for which a series of in vitro and in vivo biological features had already been established [Glia 36 (2001) 375] and were able to show that their characteristic infrared spectra refle...
