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Le Gall, Maude André Bado Le Beyec, Johanne
Published in
Cahiers de Nutrition et de Diététique
La plasticité d'un matériau est sa propriété à modifier sa forme sous l'effet d'une action et à la conserver à l'arrêt de cette action. Par analogie, la plasticité neuronale décrit comment des neurones s'étendent, se rétractent ou se réorganisent en fonction de l'activité des synapses et des neurones qu'ils rencontrent et comment au niveau des syna...
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Cavin, Jean-Baptiste André Bado Le Gall, Maude
Published in
Trends in Endocrinology and Metabolism
The gastrointestinal (GI) tract can play a direct role in glucose homeostasis by modulating the digestion and absorption of carbohydrates and by producing the incretin hormones. In recent years, numerous studies have focused on intestinal adaptation following bariatric surgeries. Changes in the number of incretin- (GLP-1, GIP) producing cells have ...
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Gillard, Laura Mayeur, Camille Robert, Véronique Pingenot, Isabelle Le Beyec, Johanne André Bado Lepage, Patricia Thomas, Muriel Joly, Francisca
Published in
Frontiers in Physiology
Short bowel syndrome (SBS) is characterized by severe intestinal malabsorption following restrictive surgery. The objective of this study was to determine the functional contribution of SBS-microbiota after resection. It is well-known that SBS-microbiota displayed specific features with a prevalence of Lactobacillus, a low amount of some anaerobic ...
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Cavin, Jean-Baptiste Voitellier, Eglantine Cluzeaud, Françoise Kapel, Nathalie Marmuse, Jean-Pierre Jean-Marc Chevallier Msika, Simon André Bado Le Gall, Maude
Published in
Journal of Integrative Cardiology
The technically easier one-anastomosis (mini) gastric bypass (MGB) is associated with similar metabolic improvements and weight loss as the Roux-en-Y gastric bypass (RYGB). However, MGB is controversial and suspected to result in greater malabsorption than RYGB. In this study, we compared macronutrient absorption and intestinal adaptation after MGB...
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Mayeur, Camille Gillard, Laura Le Beyec, Johanne André Bado Joly, Francisca
Published in
Microorganisms
Extensive resection of small bowel often leads to short bowel syndrome (SBS). SBS patients develop clinical mal-absorption and dehydration relative to the reduction of absorptive area, acceleration of gastrointestinal transit time and modifications of the gastrointestinal intra-luminal environment. As a consequence of severe mal-absorption, patient...
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Gillard, Laura Billiauws, Lore Stan-Iuga, Bogdan Ribeiro-Parenti, Lara Jarry, Anne-Charlotte Cavin, Jean-Baptiste Cluzeaud, Françoise Mayeur, Camille Thomas, Muriel Freund, Jean-Noël
...
Published in
Scientific Reports
Short bowel syndrome (SBS) patients developing hyperphagia have a better outcome. Gastrointestinal endocrine adaptations help to improve intestinal functions and food behaviour. We investigated neuroendocrine adaptations in SBS patients and rat models with jejuno-ileal (IR-JI) or jejuno-colonic (IR-JC) anastomosis with and without parenteral nutrit...
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Le Gall, Maude André Bado Cavin, Jean-Baptiste
Published in
Gastroenterology
We thank Pattou, Daoudi and Baud for their interest in our work 1 , as well as for their complementary work 2 , on intestinal absorption of ingested glucose after Roux-en-Y Gastric Bypass (RYGB). Based on their recent data obtained with a minipig model of RYGB, they claim this bariatric surgery to affect postprandial glucose metabolism primarily by...
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Cavin, Jean-Baptiste Couvelard, Anne Lebtahi, Rachida Ducroc, Robert Arapis, Konstantinos Voitellier, Eglantine Cluzeaud, Françoise Gillard, Laura Hourseau, Muriel Mikail, Nidaa
...
Published in
Gastroenterology
Background & Aims: Bariatric surgeries, such as Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG), are the most effective approaches to resolve type 2 diabetes in obese individuals. Alimentary glucose absorption and intestinal disposal of blood glucose have not been directly compared between individuals or animals that underwent ...
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Aranias, Thomas Grosfeld, Alexandra Poitou, Christine Omar, Amal Ait Le Gall, Maude Miquel, Sylvie Garbin, Kévin Ribeiro, Agnès Bouillot, Jean-Luc André Bado
...
Published in
Journal of Nutritional Science
The enterohormone glucagon-like peptide-1 (GLP-1) is required to amplify glucose-induced insulin secretion that facilitates peripheral glucose utilisation. Alteration in GLP-1 secretion during obesity has been reported but is still controversial. Due to the high adaptability of intestinal cells to environmental changes, we hypothesised that the den...
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Snoussi, Chahira Ducroc, Robert Hamdaoui, Mohamed Hédi Dhaouadi, Karima Abaidi, Houda Cluzeaud, Francoise Nazaret, Corinne Le Gall, Maude André Bado
Published in
The Journal of Nutritional Biochemistry
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Le Roy, Tiphaine Llopis, Marta Lepage, Patricia Bruneau, Aurélia Rabot, Sylvie Bevilacqua, Claudia Martin, Patrice Philippe, Catherine Walker, Francine André Bado
...
Published in
Gut
Differences in microbiota composition can determine response to a HFD in mice. These results further demonstrate that the gut microbiota contributes to the development of NAFLD independently of obesity.
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Hindlet, Patrick Barraud, Claire Boschat, Laura Farinotti, Robert André Bado Buyse, Marion
Published in
Molecular Pharmacology
The intestinal H(+)/peptide cotransporter 1 (PepT1) plays a major role in nitrogen supply to the body by mediating intestinal absorption of di- and tripeptides. Previous studies have reported that in animal models of type 2 diabetes/obesity, PepT1 activity and expression were markedly reduced. This prompted us to investigate the effects of two anti...
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Baudry, Charlotte Reichardt, François Marchix, Justine André Bado Schemann, Michael des Varannes, Stanislas Bruley Neunlist, Michel Moriez, Raphaël
Published in
The Journal of Physiology
Nutritional factors can induce profound neuroplastic changes in the enteric nervous system (ENS), responsible for changes in gastrointestinal (GI) motility. However, long-term effects of a nutritional imbalance leading to obesity, such as Western diet (WD), upon ENS phenotype and control of GI motility remain unknown. Therefore, we investigated the...
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Ducroc, Robert Sakar, Yassine Fanjul, Carmen Barber, Ana André Bado Lostao, Maria Pilar
Published in
American Journal of Physiology-Gastrointestinal and Liver Physiology
L-glutamine is the primary metabolic fuel for enterocytes. Glutamine from the diet is transported into the absorptive cells by two sodium-dependent neutral amino acid transporters present at the apical membrane: ASCT2/SLC1A5 and B(0)AT1/SLC6A19. We have demonstrated that leptin is secreted into the stomach lumen after a meal and modulates the trans...
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Sakar, Yassine Meddah, Bouchra El Abbes Faouzi, Moulay Cherrah, Yahia André Bado Ducroc, Robert
Published in
Journal of physiology and pharmacology
Metformin is an orally administered drug that lowers blood glucose and improves insulin sensitivity in patients with non insulin-dependent diabetes. Although the antihyperglycemic effect of metformin has been extensively studied, its cellular mechanism(s) of action (including the effect on enterocyte) remains to be defined. This study was designed ...
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SAKAR, Yassine André Bado
Les signaux moléculaires produits en réponse au repas le long du tractus gastro-intestinal ont été largement impliqués dans le contrôle de l’homéostasie énergétique. La leptine produite par l’estomac fait partie de ces signaux car elle contrôle à court terme les apports énergétiques via les afférences du nerf vague et via l’absorption des nutriment...
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Sakar, Yassine Nazaret, Corinne Lettéron, Philippe Ait Omar, Amal Avenati, Mathilde Viollet, Benoît Ducroc, Robert André Bado
Published in
PLoS ONE
BACKGROUND AND AIMS: The small intestine is the major site of absorption of dietary sugars. The rate at which they enter and exit the intestine has a major effect on blood glucose homeostasis. In this study, we determine the effects of luminal leptin on activity/expression of GLUT2 and GLUT5 transporters in response to sugars intake and analyse the...
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Hindlet, Patrick André Bado Kamenicky, Peter Deloménie, Claudine Bourasset, Fanchon Nazaret, Corinne Farinotti, Robert Buyse, Marion
Published in
Journal of Biological Chemistry
Leptin is a major determinant of energy homeostasis, acting both centrally and in the gastrointestinal tract. We previously reported that acute leptin treatment enhances the absorption of di- and tripeptides via the proton-dependent PepT1 transporter. In this study, we investigated the long term effect of leptin on PepT1 levels and activity in Caco...
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Begriche, Karima Lettéron, Philippe Abbey-Toby, Adjé Vadrot, Nathalie Robin, Marie-Anne André Bado Pessayre, Dominique Fromenty, Bernard
Published in
AJP Endocrinology and Metabolism
Partial leptin deficiency is not uncommon in the general population. We hypothesized that leptin insufficiency could favor obesity, nonalcoholic steatohepatitis (NASH), and other metabolic abnormalities, particularly under high calorie intake. Thus, mice partially deficient in leptin (ob/+) and their wild-type (+/+) littermates were fed for 4 mo wi...
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Hindlet, Patrick André Bado Farinotti, Robert Buyse, Marion
Published in
Journal of Pharmacology and Experimental Therapeutics
The H+-coupled peptide cotransporter 1 (PepT1) mediates absorption of peptides and peptidomimetic drugs. Acute luminal leptin was reported to induce translocation of PepT1 to the enterocyte membrane in vitro and in vivo in the rat, resulting in enhanced peptide and peptidomimetic drug absorption. In this study, we analyzed chronic effects of leptin...