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Ca, Jimenez-Junca Jc, Gumy Alexander Sher K, Niranjan
Published in
Journal of Food Science
Rheology of milk foams generated by steam injection was studied during the transient destabilization process using steady flow and dynamic oscillatory techniques: yield stress (τy) values were obtained from a stress ramp (0.2 to 25 Pa) and from strain amplitude sweep (0.001 to 3 at 1 Hz of frequency); elastic (G′) and viscous (G″) moduli were meas...
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Ca, Jimenez-Junca Jc, Gumy Alexander Sher K, Niranjan
Published in
Journal of Food Science
Rheology of milk foams generated by steam injection was studied during the transient destabilization process using steady flow and dynamic oscillatory techniques: yield stress (τy) values were obtained from a stress ramp (0.2 to 25 Pa) and from strain amplitude sweep (0.001 to 3 at 1 Hz of frequency); elastic (G′) and viscous (G″) moduli were meas...
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H, Lorach G, Goetz R, Smith X, Lei Y, Mandel T, Kamins K, Mathieson P, Huie J, Harris Alexander Sher
...
Published in
Nature Medicine
Patients with retinal degeneration lose sight due to the gradual demise of photoreceptors. Electrical stimulation of surviving retinal neurons provides an alternative route for the delivery of visual information. We demonstrate that subretinal implants with 70-μm-wide photovoltaic pixels provide highly localized stimulation of retinal neurons in ra...
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Jl, Gauthier Gd, Field Alexander Sher M, Greschner J, Shlens Alan Litke Ej, Chichilnisky
Published in
PLoS Biology
In the visual system, large ensembles of neurons collectively sample visual space with receptive fields (RFs). A puzzling problem is how neural ensembles provide a uniform, high-resolution visual representation in spite of irregularities in the RFs of individual cells. This problem was approached by simultaneously mapping the RFs of hundreds of pri...
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Jw, Triplett C, Pfeiffenberger J, Yamada Bk, Stafford Nt, Sweeney Am, Litke Alexander Sher Aa, Koulakov Da, Feldheim
Published in
Proceedings of the National Academy of Sciences
Topographic maps are the primary means of relaying spatial information in the brain. Understanding the mechanisms by which they form has been a goal of experimental and theoretical neuroscientists for decades. The projection of the retina to the superior colliculus (SC)/tectum has been an important model used to show that graded molecular cues and ...
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K, Mathieson J, Loudin G, Goetz P, Huie L, Wang Ti, Kamins L, Galambos R, Smith Js, Harris Alexander Sher
...
Published in
Nature Photonics
Retinal degenerative diseases lead to blindness due to loss of the "image capturing" photoreceptors, while neurons in the "image processing" inner retinal layers are relatively well preserved. Electronic retinal prostheses seek to restore sight by electrically stimulating surviving neurons. Most implants are powered through inductive coils, requiri...
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E, Doi Jl, Gauthier Gd, Field J, Shlens Alexander Sher M, Greschner Ta, Machado Lh, Jepson K, Mathieson De, Gunning
...
Published in
Journal of Neuroscience
Sensory neurons have been hypothesized to efficiently encode signals from the natural environment subject to resource constraints. The predictions of this efficient coding hypothesis regarding the spatial filtering properties of the visual system have been found consistent with human perception, but they have not been compared directly with neural ...
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A, Tang D, Jackson J, Hobbs W, Chen Jl, Smith H, Patel A, Prieto D, Petrusca Mi, Grivich Alexander Sher
...
Published in
Journal of Neuroscience
Multineuron firing patterns are often observed, yet are predicted to be rare by models that assume independent firing. To explain these correlated network states, two groups recently applied a second-order maximum entropy model that used only observed firing rates and pairwise interactions as parameters (Schneidman et al., 2006; Shlens et al., 2006...
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J, Elstrott A, Anishchenko M, Greschner Alexander Sher Am, Litke Ej, Chichilnisky Mb, Feller
Published in
Neuron
Direction selectivity in the retina requires the asymmetric wiring of inhibitory inputs onto four subtypes of On-Off direction-selective ganglion cells (DSGCs), each preferring motion in one of four cardinal directions. The primary model for the development of direction selectivity is that patterned activity plays an instructive role. Here, we use ...
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C, Sekirnjak Lh, Jepson P, Hottowy Alexander Sher W, Dabrowski Alan Litke Ej, Chichilnisky
Published in
Journal of Neurophysiology
Retinitis pigmentosa (RP) is a leading cause of degenerative vision loss, yet its progressive effects on visual signals transmitted from the retina to the brain are not well understood. The transgenic P23H rat is a valuable model of human autosomal dominant RP, exhibiting extensive similarities to the human disease pathology, time course, and elect...
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Ta, Szuts V, Fadeyev S, Kachiguine Alexander Sher Mv, Grivich M, Agrochão P, Hottowy W, Dabrowski Ev, Lubenov Ag, Siapas
...
Published in
Nature Neuroscience
Conventional neural recording systems restrict behavioral experiments to a flat indoor environment compatible with the cable that tethers the subject to recording instruments. To overcome these constraints, we developed a wireless multi-channel system for recording neural signals from rats. The device takes up to 64 voltage signals from implanted e...
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Gd, Field M, Greschner Jl, Gauthier C, Rangel J, Shlens Alexander Sher Dw, Marshak Alan Litke Ej, Chichilnisky
Published in
Nature Neuroscience
Small bistratified cells (SBCs) in the primate retina carry a major blue-yellow opponent signal to the brain. We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input. SBCs exhibited robust responses under low scotopic conditions. Physiological and anatomical experiments indicated that this rod input arose f...
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H, Lorach G, Goetz R, Smith X, Lei Y, Mandel T, Kamins K, Mathieson P, Huie J, Harris Alexander Sher
...
Published in
Nature Medicine
Patients with retinal degeneration lose sight due to the gradual demise of photoreceptors. Electrical stimulation of surviving retinal neurons provides an alternative route for the delivery of visual information. We demonstrate that subretinal implants with 70-μm-wide photovoltaic pixels provide highly localized stimulation of retinal neurons in ra...
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J, Freeman Gd, Field Ph, Li M, Greschner De, Gunning K, Mathieson Alexander Sher Alan Litke L, Paninski Ep, Simoncelli
...
Published in
eLife
The function of a neural circuit is shaped by the computations performed by its interneurons, which in many cases are not easily accessible to experimental investigation. Here, we elucidate the transformation of visual signals flowing from the input to the output of the primate retina, using a combination of large-scale multi-electrode recordings f...
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C, Sekirnjak P, Hottowy Alexander Sher W, Dabrowski Alan Litke Ej, Chichilnisky
Published in
Journal of Neuroscience
The development of retinal implants for the blind depends crucially on understanding how neurons in the retina respond to electrical stimulation. This study used multielectrode arrays to stimulate ganglion cells in the peripheral macaque retina, which is very similar to the human retina. Analysis was restricted to parasol cells, which form one of t...
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A, Tang D, Jackson J, Hobbs W, Chen Jl, Smith H, Patel A, Prieto D, Petrusca Mi, Grivich Alexander Sher
...
Published in
Journal of Neuroscience
Multineuron firing patterns are often observed, yet are predicted to be rare by models that assume independent firing. To explain these correlated network states, two groups recently applied a second-order maximum entropy model that used only observed firing rates and pairwise interactions as parameters (Schneidman et al., 2006; Shlens et al., 2006...
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Ph, Li Jl, Gauthier M, Schiff Alexander Sher D, Ahn Gd, Field M, Greschner Em, Callaway Alan Litke Ej, Chichilnisky
...
Published in
Journal of Neuroscience
This study combines for the first time two major approaches to understanding the function and structure of neural circuits: large-scale multielectrode recordings, and confocal imaging of labeled neurons. To achieve this end, we develop a novel approach to the central problem of anatomically identifying recorded cells, based on the electrical image:...
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Ph, Li Gd, Field M, Greschner D, Ahn De, Gunning K, Mathieson Alexander Sher Alan Litke Ej, Chichilnisky
Published in
Neuron
The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording from multiple retinal ganglion cells of identified types. The visual signal initiated by an individual cone produced strong respo...
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Alexander Sher Bw, Jones P, Huie Ym, Paulus D, Lavinsky Ls, Leung H, Nomoto C, Beier Re, Marc D, Palanker
...
Published in
Journal of Neuroscience
CNS neurons change their connectivity to accommodate a changing environment, form memories, or respond to injury. Plasticity in the adult mammalian retina after injury or disease was thought to be limited to restructuring resulting in abnormal retinal anatomy and function. Here we report that neurons in the mammalian retina change their connectivit...
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H, Lorach J, Kung C, Beier Y, Mandel R, Dalal P, Huie J, Wang S, Lee Alexander Sher Bw, Jones
...
Published in
Investigative Ophthalmology & Visual Science