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J, Voog Sl, Sandall Gr, Hime Lp, Resende M, Loza-Coll Aaron Aslanian 3rd, Yates Jr Tony Hunter Mt, Fuller Dl, Jones
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Published in
Cell Reports
Stem cells reside within specialized microenvironments, or niches, that control many aspects of stem cell behavior. Somatic hub cells in the Drosophila testis regulate the behavior of cyst stem cells (CySCs) and germline stem cells (GSCs) and are a primary component of the testis stem cell niche. The shutoff (shof) mutation, characterized by premat...
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Ms, Chaurushiya Ce, Lilley Aaron Aslanian Jill Meisenhelder Dc, Scott S, Landry S, Ticau C, Boutell 3rd, Yates Jr Ba, Schulman
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Published in
Molecular Cell
Viral hijacking of cellular processes relies on the ability to mimic the structure or function of cellular proteins. Many viruses encode ubiquitin ligases to facilitate infection, although the mechanisms by which they select their substrates are often unknown. The Herpes Simplex Virus type-1-encoded E3 ubiquitin ligase, ICP0, promotes infection thr...
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H, Ma Bk, Han M, Guaderrama Aaron Aslanian 3rd, Yates Jr Tony Hunter C, Wittenberg
Published in
Molecular and Cellular Biology
The reversible nature of protein phosphorylation dictates that any protein kinase activity must be counteracted by protein phosphatase activity. How phosphatases target specific phosphoprotein substrates and reverse the action of kinases, however, is poorly understood in a biological context. We address this question by elucidating a novel function...
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Aaron Aslanian 3rd, Yates Jr Tony Hunter
Published in
DNA Repair
Faithful transmission of genetic material is essential for cell viability and organism health. The occurrence of DNA damage, due to either spontaneous events or environmental agents, threatens the integrity of the genome. The consequences of these insults, if allowed to perpetuate and accumulate over time, are mutations that can lead to the develop...
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Cs, Lu Ln, Truong Aaron Aslanian Lz, Shi Y, Li Py, Hwang Kh, Koh Tony Hunter 3rd, Yates Jr Mw, Berns
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Published in
Journal of Biological Chemistry
Ubiquitination plays an important role in the DNA damage response. We identified a novel interaction of the E3 ubiquitin ligase RNF8 with Nbs1, a key regulator of DNA double-strand break (DSB) repair. We found that Nbs1 is ubiquitinated both before and after DNA damage and is a direct ubiquitination substrate of RNF8. We also identified key residue...
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Yw, Zhang J, Brognard C, Coughlin Z, You M, Dolled-Filhart Aaron Aslanian G, Manning Rt, Abraham Tony Hunter
Published in
Molecular Cell
ATR and Chk1 are two key protein kinases in the replication checkpoint. Activation of ATR-Chk1 has been extensively investigated, but checkpoint termination and replication fork restart are less well understood. Here, we report that DNA damage not only activates Chk1, but also exposes a degron-like region at the carboxyl terminus of Chk1 to an Fbx6...
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Am, Denli I, Narvaiza Be, Kerman M, Pena C, Benner Mc, Marchetto Jk, Diedrich Aaron Aslanian J, Ma Jj, Moresco
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Published in
Cell
LINE-1 retrotransposons are fast-evolving mobile genetic entities that play roles in gene regulation, pathological conditions, and evolution. Here, we show that the primate LINE-1 5 UTR contains a primate-specific open reading frame (ORF) in the antisense orientation that we named ORF0. The gene product of this ORF localizes to promyelocytic leukem...
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Li Ma Aaron Aslanian Huaiyu Sun M, Jin Yu Shi 3rd, Yates Jr Tony Hunter
Published in
Molecular & Cellular Proteomics
Post-translational modification by SUMO is a highly conserved pathway in eukaryotes that plays very important regulatory roles in many cellular processes. Deregulation of the SUMO pathway contributes to the development and progression of many diseases including cancer. Therefore, identifying additional SUMO substrates and studying how their cellula...
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Steve Fuhs Jill Meisenhelder Aaron Aslanian Li Ma A, Zagorska M, Stankova A, Binnie F, Al-Obeidi J, Mauger G, Lemke
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Published in
Cell
Histidine phosphorylation (pHis) is well studied in bacteria; however, its role in mammalian signaling remains largely unexplored due to the lack of pHis-specific antibodies and the lability of the phosphoramidate (P-N) bond. Both imidazole nitrogens can be phosphorylated, forming 1-phosphohistidine (1-pHis) or 3-phosphohistidine (3-pHis). We have ...