I joined the Hunter lab as a postdoc two years ago after completing my PhD study at Columbia University in New York City. My current interest of work is to investigate the physiological effects of tumor microenvironment on the cancer cells at distinct stages of tumorigenesis and to elucidate the molecular mechanisms involved in the cell-cell communication among cancer cells and surrounding stromal cells.
Yu Shi
Research Associate
Institution:
Hunter Lab
La Jolla, CA, United States
https://www.mysciencework.com/profile/yu.shi
Summary
Published articles Show More
Structure-based prediction of protein-protein interactions on a genome-wide scale.
...Published in Nature
The genome-wide identification of pairs of interacting proteins is an important step in the elucidation of cell regulatory mechanisms. Much of our present knowledge derives from high-throughput techniques such as the yeast two-hybrid assay and affinity purification, as well as from manual curation of experiments on individual systems. A variety of ...
Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.
...Published in Proceedings of the National Academy of Sciences
Systematic characterization of intercellular signaling approximating the physiological conditions of stimulation that involve direct cell-cell contact is challenging. We describe a proteomic strategy to analyze physiological signaling mediated by the T-cell costimulatory receptor CD28. We identified signaling pathways activated by CD28 during direc...
Identification of small ubiquitin-like modifier substrates with diverse functions using the Xenopus egg extract system.
Published in Molecular & Cellular Proteomics
Post-translational modification by SUMO is a highly conserved pathway in eukaryotes that plays very important regulatory roles in many cellular processes. Deregulation of the SUMO pathway contributes to the development and progression of many diseases including cancer. Therefore, identifying additional SUMO substrates and studying how their cellula...
