Xavier Coumoul

Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL6/J Diet-Induced Obesity Mouse M...

Published in Environmental Health Perspectives

Background: Exposure to persistent organic pollutants (POPs) has been associated with the progression of chronic liver diseases, yet the contribution of POPs to the development of fibrosis in non-alcoholic fatty liver disease (NAFLD), a condition closely linked to obesity, remains poorly documented. Objectives: We investigated the effects of s...

Exposure to metal oxide nanoparticles administered at occupationally relevant doses induces pulmonary effects in mice

Published in Nanotoxicology

In spite of the great promises that the development of nanotechnologies can offer, concerns regarding potential adverse health effects of occupational exposure to nanoparticle (NP) is raised. We recently identified metal oxide NP in lung tissue sections of welders, located inside macrophages infiltrated in fibrous regions. This suggests a role of t...

Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration

Published in Toxicological Sciences

The regulation of cell migration is a key factor for the dissemination of metastatic cells during tumor progression. Aquaporins are membrane channels which allow transmembrane fluxes of water and glycerol in cells in a variety of mammalian tissues. Here, we show that AQP3, which has been incriminated in cancer progression, is regulated by the AhR, ...

Etude du rôle du récepteur aux hydrocarbures aromatiques ou AhR dans le développement et l'homéostasie du système nerveu...

Le récepteur aux hydrocarbures aromatiques (AhR) est un facteur de transcription de la famille bHLH/PAS, activé par différents ligands exogènes dont les hydrocarbures aromatiques polycycliques ou halogénés (dioxines). A ce titre, il est décrit historiquement comme un récepteur de xénobiotiques dont le principal rôle est l’élimination de ces composé...