Tambet Teesalu
Staff Scientist
Institution:
Ruoslahti Lab
Santa Barbara, CA, United States
https://www.mysciencework.com/profile/tambet.teesalu
Summary
Published articles Show More
Transtumoral targeting enabled by a novel neuropilin-binding peptide
Published in Oncogene
We have recently described a class of peptides that improve drug delivery by increasing penetration of drugs into solid tumors. These peptides contain a C-terminal C-end Rule (CendR) sequence motif (R/K)XX(R/K), which is responsible for cell internalization and tissue-penetration activity. Tumor-specific CendR peptides contain both a tumor-homing m...
A high-throughput label-free nanoparticle analyser.
Published in Nature Nanotechnology
Synthetic nanoparticles and genetically modified viruses are used in a range of applications, but high-throughput analytical tools for the physical characterization of these objects are needed. Here we present a microfluidic analyser that detects individual nanoparticles and characterizes complex, unlabelled nanoparticle suspensions. We demonstrate...
Selection of phage-displayed peptides on live adherent cells in microfluidic channels.
...Published in Proceedings of the National Academy of Sciences
Affinity reagents that bind to specific molecular targets are an essential tool for both diagnostics and targeted therapeutics. There is a particular need for advanced technologies for the generation of reagents that specifically target cell-surface markers, because transmembrane proteins are notoriously difficult to express in recombinant form. We...
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