Taeho Kim
Institution:
Kowalczykowski Lab
Davis, CA, United States
https://www.mysciencework.com/profile/taeho.kim
Summary
Published articles Show More
BRCA2 regulates DMC1-mediated recombination through the BRC repeats.
Published in Proceedings of the National Academy of Sciences
In somatic cells, BRCA2 is needed for RAD51-mediated homologous recombination. The meiosis-specific DNA strand exchange protein, DMC1, promotes the formation of DNA strand invasion products (joint molecules) between homologous molecules in a fashion similar to RAD51. BRCA2 interacts directly with both human RAD51 and DMC1; in the case of RAD51, thi...
BRCA2 is epistatic to the RAD51 paralogs in response to DNA damage.
Published in DNA Repair
Homologous recombination plays an important role in the high-fidelity repair of DNA double-strand breaks. A central player in this process, RAD51, polymerizes onto single-stranded DNA and searches for homology in a duplex donor DNA molecule, usually the sister chromatid. Homologous recombination is a highly regulated event in mammalian cells: some ...
A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Re...
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Published in Molecular Cell
Repair of DNA interstrand crosslinks requires action of multiple DNA repair pathways, including homologous recombination. Here, we report a de novo heterozygous T131P mutation in RAD51/FANCR, the key recombinase essential for homologous recombination, in a patient with Fanconi anemia-like phenotype. In vitro, RAD51-T131P displays DNA-independent AT...
