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Sophie Lotersztajn
Coordinateur du Département, Département d’Hépato-Gastroentérologie (HGE)
Institution:
USPC - SET - SVS
Summary
Published articles Show More
Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL6/J Diet-Induced Obesity Mouse M...
...Published in Environmental Health Perspectives
Background: Exposure to persistent organic pollutants (POPs) has been associated with the progression of chronic liver diseases, yet the contribution of POPs to the development of fibrosis in non-alcoholic fatty liver disease (NAFLD), a condition closely linked to obesity, remains poorly documented. Objectives: We investigated the effects of s...
Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility t...
Published in Hepatology
Carbohydrate responsive element binding protein (ChREBP) is central for de novo fatty acid synthesis under physiological conditions and in the context of nonalcoholic fatty liver disease. We explored its contribution to alcohol-induced steatosis in a mouse model of binge drinking as acute ethanol (EtOH) intoxication has become an alarming health pr...
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic...
...Published in Journal of Hepatology
These findings underscore a critical role for ASMase in diet-induced NASH and suggest the potential of amitriptyline as a treatment for patients with NASH.
Experience
Coordinateur du Département
Université Paris Diderot
Département d’Hépato-Gastroentérologie (HGE); UMR 1149, Centre de Recherche sur l'Inflamation (CRI); UFR de Médecine
