Shig did his undergraduate studies at Franklin & Marshall College in Lancaster, PA where he worked in the lab of Dr. Ryan Mehl using non-sense suppression unnatural amino acid (UAA) tools to study and utilize enzyme substrate promiscuity, and developed UAAs as FRET probes for studying protein folding and stability. He is currently a graduate student in the O'Shea lab through UCSD Biological Sciences. He is developing a new strategy for adenovirus targeting to enable controlled infection of refractory cell types, and manipulating virus genes that interact with the Rb tumor-suppressor pathway to develop selective and potent oncolytic adenoviruses.
Shigeki Miyake-Stoner
Graduate Student
Institution:
O'Shea Lab
La Jolla, CA, United States
https://www.mysciencework.com/profile/shigeki.miyake.stoner
Summary
Published articles Show More
Metabolism goes viral.
Published in Cell Metabolism
Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides f...
