La, Saddic Le, West A, Aslanian 3rd, Yates Jr Seth Rubin O, Gozani J, Sage
Published in
Journal of Biological Chemistry
The retinoblastoma tumor suppressor (RB) is a central cell cycle regulator and tumor suppressor. RB cellular functions are known to be regulated by a diversity of post-translational modifications such as phosphorylation and acetylation, raising the possibility that RB may also be methylated in cells. Here we demonstrate that RB can be methylated by...
Am, Hegnauer N, Hustedt K, Shimada Bl, Pike M, Vogel P, Amsler Seth Rubin F, Van Leeuwen A, Guénolé H, Van Attikum
...
Published in
The EMBO Journal
DNA replication fork stalling poses a major threat to genome stability. This is counteracted in part by the intra-S phase checkpoint, which stabilizes arrested replication machinery, prevents cell-cycle progression and promotes DNA repair. The checkpoint kinase Mec1/ATR and RecQ helicase Sgs1/BLM contribute synergistically to fork maintenance on hy...