Serge Luquet
Responsable de l'équipe, Contrôle Central du Comportement Alimentaire et de la Dépense Énergétique
Institution:
USPC - SET - SVS
Summary
Published articles Show More
Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucr...
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Published in AJP Endocrinology and Metabolism
Impaired skeletal muscle mitochondrial fatty acid oxidation (mFAO) has been implicated in the etiology of insulin resistance. Carnitine palmitoyltransferase-1 (CPT1) is a key regulatory enzyme of mFAO whose activity is inhibited by malonyl-CoA, a lipogenic intermediate. Whereas increasing CPT1 activity in vitro has been shown to exert a protective ...
NOV/CCN3: A new adipocytokine involved in obesity-associated insulin resistance
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Published in Diabetes
Identification of new adipokines that potentially link obesity to insulin resistance represents a major challenge. We have recently shown that NOV/CCN3, a multifunctional matricellular protein, is synthesized and secreted by adipose tissue, with plasma levels highly correlated with body mass index. NOV has been previously involved in tissue repair,...
Palatability Can Drive Feeding Independent of AgRP Neurons.
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Published in Cell Metabolism
Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesit...
Theses Show More
Implication de la détection des tryglycérides nutritionnels par le cerveau dans la régularisation de l'homéostasie énerg...
FR
Rôles physiologiques du récepteur nucléaire aux lipides "Peroxisome proliferator-activated receptor O" (implication dans...
Peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors which regulate fatty acid and carbohydrate metabolism. Among the three known members (PPARa,g,b/d), role of PPARd is not clearly established. We used a positive approach, by over-expressing the native receptor and a negative one, by expressing a dominant-negative form of ...
Experience
Responsable de l'équipe
Université Paris Diderot
Contrôle Central du Comportement Alimentaire et de la Dépense Énergétique; UMR 8251, Unité de Biologie Fonctionnelle et adaptative (BFA); UFR Sciences du Vivant
