Serge Luquet
Responsable de l'équipe, Contrôle Central du Comportement Alimentaire et de la Dépense Énergétique
Institution:
USPC - SET - SVS
Summary
Published articles Show More
Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucr...
...Published in AJP Endocrinology and Metabolism
Impaired skeletal muscle mitochondrial fatty acid oxidation (mFAO) has been implicated in the etiology of insulin resistance. Carnitine palmitoyltransferase-1 (CPT1) is a key regulatory enzyme of mFAO whose activity is inhibited by malonyl-CoA, a lipogenic intermediate. Whereas increasing CPT1 activity in vitro has been shown to exert a protective ...
NOV/CCN3: A new adipocytokine involved in obesity-associated insulin resistance
...Published in Diabetes
Identification of new adipokines that potentially link obesity to insulin resistance represents a major challenge. We have recently shown that NOV/CCN3, a multifunctional matricellular protein, is synthesized and secreted by adipose tissue, with plasma levels highly correlated with body mass index. NOV has been previously involved in tissue repair,...
Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.
...Published in Nature Medicine
Accumulation of visceral adipose tissue correlates with elevated inflammation and increased risk of metabolic diseases. However, little is known about the molecular mechanisms that control its pathological expansion. Transcription factor interferon regulatory factor 5 (IRF5) has been implicated in polarizing macrophages towards an inflammatory phen...
Theses Show More
Experience
Responsable de l'équipe
Université Paris Diderot
Contrôle Central du Comportement Alimentaire et de la Dépense Énergétique; UMR 8251, Unité de Biologie Fonctionnelle et adaptative (BFA); UFR Sciences du Vivant
