Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines
Published in Bioorganic & Medicinal Chemistry Letters
Histone deacetylases (HDACs) are well-established, promising targets for anticancer therapy due to their critical role in cancer development. Accordingly, an increasing number of HDAC inhibitors displaying cytotoxic effects against cancer cells have been reported. Among them, a large panel of chemical struc- tures was described including coumarin-c...
Published in Journal of Natural Products
A chemical investigation of the endophytic fungus Epicoccum nigrum isolated from leaves of Mentha suaveolens collected in Morocco resulted in the isolation of five new polyketides, epicocconigrones A and B (1 and 2), 3-methoxyepicoccone B (3), 3-methoxyepicoccone (4), and 2,3,4-trihydroxy-6-(methoxymethyl)-5-methylbenzaldehyde (5), together with fi...
Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases
Published in Cancer Letters
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate cellular processes by mod- ifying the acetylation status of many proteins. Pathologically altered HDAC activity contributes to cancer development and thus characterization of novel acetylation modulators is important for future anti-can- cer therapies. In this study, we ide...
PhD October 2011 - September 2014
Preclinical evaluation of a series of anti-caner 4-hydroxybenzoic acid derivatives as histone deacetylase inhibitors