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Seidel Carole
Disciplines:
Biology
Nancy, France
https://www.mysciencework.com/profile/seidel.carole
Summary
Published articles Show More
4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90a chaperone ac...
Published in Biochemical Pharmacology in Jan 02, 2016
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including a-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
Chromatin-modifying agents in anti-cancer therapy
Published in Biochimie
Epigenetic alterations are involved in every step of carcinogenesis. The development of chromatin- modifying agents (CMAs) has provided the ability to fight cancer by reversing these alterations. Currently, four CMAs have been approved for cancer treatment; two DNA demethylating agents and two deacetylase inhibitors. A number of promising CMAs are ...
Histone deacetylase modulators provided by Mother Nature
Published in Genes & Nutrition
Protein acetylation status results from a balance between histone acetyltransferase and histone deacetylase (HDAC) activities. Alteration of this balance leads to a disruption of cellular integrity and participates in the development of numerous diseases, including cancer. Therefore, modulation of these activities appears to be a promising approach...
Experience
Education
PhD October 2011 - September 2014
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC) (Luxembourg LU)
Preclinical evaluation of a series of anti-caner 4-hydroxybenzoic acid derivatives as histone deacetylase inhibitors